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Warnecke A, Prenzler N, Harre J, Köhl U, Gärtner L, Lenarz T, Laner-Plamberger S, Wietzorrek G, Staecker H, Lassacher T, Hollerweger J, Gimona M, Rohde E. First-in-human intracochlear application of human stromal cell-derived extracellular vesicles. J Extracell Vesicles. (2021), 10, 8, e12094. doi: 10.1002/jev2.12094
Weiss R, Gerdes W, Berthold R, Sack U, Koehl U, Hauschildt S, Grahnert A. Comparison of three CD3-specific separation methods leading to labeled and label-free T cells. Cells (2021), 10, 11, 2824. doi: 10.3390/cells10112824
Wendt R, Nickel O, Kalbitz S, Fertey J, Ulbert S, Wolf J, Lübbert C, Borte S. Comparison of pre-analytical characteristics for molecular and serological diagnostics of COVID-19. GMS Hyg Infect Control (2021), 16, Doc03. doi: 10.3205/dgkh000374
Weyerer V, Strissel P L, Stöhr C, Eckstein M, Wach S, Taubert H, Brandl L, Geppert C I, Wullich B, Cynis H, Beckmann M W, Seliger B, Hartmann A, Strick R. Endogenous retroviral-k envelope is a novel tumor antigen and prognostic indicator of renal cell carcinoma. Front Oncol. (2021), 11, 657187. doi: 10.3389/fonc.2021.657187
Zeynalova S, Bucksch K, Scholz M, Yahiaoui-Doktor M, Gross M, Loeffler M, Melzer S, Tárnok A. Monocyte subtype counts are associated with 10-year cardiovascular disease risk as determined by the Framingham Risk Score among subjects of the LIFE-Adult study. PLoS One (2021), 16, 3, e0247480. doi: 10.1371/journal.pone.0247480
Buchbeiträge
Schmidt M, Rohde F, Braumann U-D. Visualization and co-registration of correlative microscopy data with the ImageJ plug-in Correlia. In: Müller-Reichert T, Verkade P (editors): Correlative Light and Electron Microscopy VI, volume 162 of Methods in Cell Biology, chapter 15, pages 353–388. Academic Press, 1st edition, March 2021, doi: 10.1016/bs.mcb.2020.10.001
Köppen J, Schulze A, Machner L, Wermann M, Eichentopf R, Guthardt M, Hähnel A, Klehm J, Kriegeskorte M, Hartlage-Rübsamen M, Morawski M, von Hörsten S, Demuth HU, Rossner S, Schilling S. Amyloid-beta peptides trigger aggregation of alpha-synuclein in vitro. Ed. by Giampietro L, Prime Archives in Molecular Sciences, Edition 2, Vide Leaf, 2021
Sonstige Publikationen
Del Zotto G, Preijers F, Tárnok A. Phenotype reports: sharing the knowledge : (an expert is a man who has made all the mistakes which can be made in a very narrow field. by Niels Bohr). Cytometry Part A (2021), 24318, doi: 10.1002/cyto.a.24318
Franz P. Immuntherapie zur Behandlung von Krebs – Unterstützung der eigenen Immunabwehr. Grün-gelbe Broschürenreihe; Sächsische Krebsgesellschaft e.V., 61 (2021)
Neuhaus V, Ueberham E, Dehmel S, Augustin J, Vucinic V, Blaudszun AR, Köhl U, Braun A, Fricke S. ATMP: der Weg in die Klinik. Forum (2021), 36, Seite 479–484. doi: 10.1007/s12312-021-00995-0
Tárnok A. Bibliometric news and more about signal transduction and disease. Cytometry Part A 99 (2021) 8, Seite 764-765. doi: 10.1002/cyto.a.24486
Tárnok A. CYTO 2020 virtual issue. Cytometry Part A (2021) Artikel-Nr.: 24305, 1 Seite. doi: 10.1002/cyto.a.24305
Tárnok A. Cytometry-on-the-chip. Cytometry Part A 99 (2021) 10, Seite 964. doi: 10.1002/cyto.a.24502
Tárnok A. Make them open and more about image cytometry. Cytometry Part A 99 (2021) 7, Seite 657-658. doi: 10.1002/cyto.a.24476
Tárnok A. OMIPs revisited. Cytometry Part A (2021) Artikel-Nr.: 24494, 1 Seite. doi: 10.1002/cyto.a.24494
Tárnok A. Phenotypes comprehensively. Cytometry Part A 99 (2021) 3, Seite 214-215. doi: 10.1002/cyto.a.24322
Tárnok A. Start of the year note 2021. Cytometry Part A 99 (2021) 1, Seite 6-7. doi: 10.1002/cyto.a.24289
Tárnok A. Single-cell systems biology, COVID-19, and vaccination. Cytometry Part A 99 (2021) 5, Seite 427-428. doi: 10.1002/cyto.a.24353
Tárnok A. Zbigniew (Zbyszek) Darzynkiewicz 1936–2021. Cytometry Part A 99 (2021) 4, Seite 310. doi: 10.1002/cyto.a.24337
Abstracts
Bathini P, Sun T, Shi Q, Zhang Y, Taudte N, Schenk M, Hettmann T, Schilling S, McDannold N J, Lemere C A. Focus ultrasound-induced blood-brain barrier opening enhances anti-pGlu3 Aβ mAb delivery and amyloid-beta plaque clearance. (Poster) Alzheimer’s Dement. 2021;17(Suppl. 2):e058725, doi: 10.1002/alz.058725
Bauer M, Zürner S, Kreuz M, Otto D, Popp G, Braumann U-D. Histological grading of the prostate carcinoma using deep learning: an unsupervised approach. In:Tomaszewski JE, Ward AD (editors): Medical Imaging 2021: Digital Pathology, volume 11603 of Proceedings of the International Society for Photonics and Optics (SPIE), 116030Y, February 2021, doi: 10.1117/12.2581043
Beneke V, Grieger K, Hartwig C, Sohn K, Blaudszun A-R, Hilger N, Sewald K, Braun A, Hesse C. Different microbial compositions in the gut shape the immune response in ex vivo intestinal tissue slices. (Poster). Fraunhofer CIMD Winter School, 5.-8.10.2021, online
Berneck BS, Rockstroh A, Barzon L, Sinigaglia A, Vocale C, Landini MP, Rabenau H, Schmidt-Chanasit J, Ulbert S. Serological differentiation of WNV and USUV induced antibodies in humans by recombinant E proteins with mutations in conserved fusion loop. Zoonoses 2021 – International Symposium on Zoonoses Research, 13.-15.10.2021, online
Ciulean SC, Geuter J, Fischer J, Köhl U, Grunwald T. Establishment of a 3D head and neck cancer cell culture model for the assessment of NK cell based therapies. Leipzig Immune ONcology (LION) Conference 2021, 9.-10.11.2021, online
Delaroque N, Treudler R, Kern K, Puder M, Simon J-C, Szardenings M. Epitopes of anti-drug-antibodies involved in dupilumab-induced serum sickness like reactions. PEGS Europe: Protein & Antibody Engineering Summit, 1.-3.11.2021, Barcelona
Eberlein V, Bayer L, Finkensieper J, Ahrends M, Hesse C, Mansuroglu Y, Dressman J, Wilde S, Standfest B, Schopf S, Beckmann J, Lange F, Thoma M, Ulbert S, Grunwald T. Protective efficacy induced by an inactivated formulated vaccine after mucosal application. 30th Annual Meeting of the Society for Virology, 25.-28.3.2021, online
Eberlein V, Bayer L, Finkensieper J, Ahrends M, Hesse C, Mansuroglu Y, Dressman J, Wilde S, Standfest B, Schopf S, Beckmann J, Lange F, Thoma M, Ulbert S, Grunwald T. Protective efficacy induced by an inactivated formulated vaccine after mucosal application. RSVVW'21 – A Global Conference on Novel RSV Preventive and Therapeutic Interventions, 10.-12.11.2021, online
Eberlein V, Bayer L, Finkensieper J, Ahrends M, Hesse C, Mansuroglu Y, Dressman J, Wilde S, Standfest B, Schopf S, Beckmann J, Lange F, Thoma M, Ulbert S, Grunwald T. Protective efficacy induced by an inactivated formulated vaccine after mucosal application. 12th Autumn School Current Concepts in Immunology, 10.-15.10.2021, Merseburg
Eberlein V, Issmail L, Uhlig N, Donner A-K, Peter A-S, Roth E, Schulz S, Fraederich K, Steinmetz T, Damm D, Hauke M, Richel E, Müller-Schmucker S, Schulz I, Habenicht K, Krey T, Pöhlmann S, McKay P, Shattock R, Wölfel R, Eichöer J, Schuh W, Neipel F, Ensser A, Mielenz D, Tenbusch M, Winkler T, Überla K, Jäck H-M, Grunwald T. Efficacy of novel neutralizing antibodies against SARS-CoV-2 infection in ACE2 transgenic mouse model. 8th European Seminar in Virology, 15.-17.10.2021, Bertinoro
Eberlein V, Issmail L, Uhlig N, Schult I, Donner A-K, Leichsenring A, Grunwald T. Evaluation of SARS-CoV-2 entry inhibitors by the ACE-2 transgenic mouse model. Fraunhofer Seminar Translational Airway Research »Models of Lung disease« 2021 - special edition »Corona«, 21.-22.1.2021, online
Finkensieper J, Issmail L, Fertey J, König U, Standfest B, Thoma M, Grunwald T, Ulbert S. Development of an automated inactivation process for the tick-borne encephalitis virus based on low energy electron irradiation. IAEA International Symposium on Sustainable Animal Production and Health: Current Status and Way Forward, 28.6.- 2.7.2021, online
Finkensieper J, Renteria-Solis Z, Thoma M, König U, Daugschies A, Ulbert S. Irradiation of zoonotic apicomplexa with low energy electrons for the development of vaccine candidates. Zoonoses 2021 – International Symposium on Zoonoses Research, 13.-15.10.2021, online
Funke N, Graf A, Schönfelder J, Hild OR. Measurements on a miniaturized FAIMS-Chip for deriving optimal operating parameters. (Poster) Conference of International Society of Ion Mobility Spectrometry - ISIMS 2021, 26.-30.7.2021, online
Funke N, Graf A, Schönfelder J, Hild OR. Bestimmung der optimalen Betriebsparameter für einen FAIMS-Chip für die Systemintegration in der Atemgas- und Urinanalytik. (Poster) MikroSystemTechnik Kongress 2021, 8.-10.11.2021, Ludwigsburg
Gnoth K, Geissler S, Feldhaus J, Taudte N, Ilse V, Rahfeld JU, Cynis H, Schilling S. Combinational therapy, concomitantly targeting post-translational modified Aβ peptides and CD33, leads to an add-on effect in passive immunotherapy. AAIC Neuroscience Next, 12.-13.10.2021, Denver, USA, online
Goldau R. Stay cool - Kryoregeneration des Dialysatwassers. 13. Jahrestagung der Deutschen Gesellschaft für Nephrologie, 23.-26.9.2021, Rostock
Graf A, Funke N, Schönfelder J, Hild OR. Entwicklung eines chip-basierten FAIMS. (Poster) 8. IMS-Anwendertreffen. 17.-19.3.2021, online
Hartwig C, Müller J, Beneke V, Blaudszun A-R, Hilger N, Hesse C, Sohn K. Hochauflösende Mikrobiomanalysen im Mausmodell mittels Next-Generation Sequencing (NGS). (Poster) Tag der Immunforschung, 12.11.2021, online
Issmail L, Möser C, Jäger C, Kleinschmidt M, Ramsbeck D, Smith D, Buchholz M, Grunwald T. Design and evaluation of novel viral entry inhibitors against respiratory syncytial virus. 30th Annual Meeting of the Society for Virology, 25.-28.3.2021, online
Issmail L, Möser C, Jäger C, Kleinschmidt M, Ramsbeck D, Smith D, Buchholz M, Grunwald T. Design and evaluation of novel viral entry inhibitors against respiratory syncytial virus. RSVVW'21 – A Global Conference on Novel RSV Preventive and Therapeutic Interventions, 10.-12.11.2021, online
Kalkhof S. Proteomics for guiding biomaterial development. Slovenian-BavarianScientific Forum, 27.5.2021, online
Kirchschlager A, Schönfelder J. VOC-Analyse von in vitro Zellkulturen mittels SPME GC FAIMS. (Poster) 8. IMS-Anwendertreffen. 17.-19.3.2021, online
Kistenmacher A-K, Walcher L, Schiefer D, v. Auw N, Hilger N, Wels WS, Ulbert S, Köhl U, Fricke S, Dünkel. A Low energy electron irradiation (LEEI)-based inactivation of ErbB2/HER2-directed chimeric antigen receptor (CAR)-NK-92 cells for therapy of glioblastoma multiforme (GBM). Leipzig Immune ONcology (LION) Conference 2021, 9.-10.11.2021, online
Kitte R, Fricke S, Köhl U, Tretbar S. Transient expression of a CD123-directed chimeric antigen receptor for safe immunotherapy of acute myeloid leukemia. Leipzig Immune ONcology (LION) Conference 2021, 9.-10.11.2021, online
Köhl U. Wie wird ATMP produziert. (Vortrag) vfa bio/ ACHSE, 28.1.2021, online
Köhl U. CARs NK. (Vortrag)3. European CAR T-Cell-Meeting, 4.-6.2.2021, online
Köhl U. CAR NK cells as an off the shelf immunotherapy. (Vortrag) 47. Annual meeting EBMT, 14.-17.3.2021, online
Köhl U. Flow cytometric in-orocess and quality control for CAR T cell manufacturing. (Vortrag) 47. Annual meeting EBMT, 14.-17.3.2021, online
Köhl U. Manufacturing of CGT with a special view to CAR effector cells. (Vortrag) CGT-Seminar (Fa. Lonza), 13.-14.4.2021, online
Köhl U. SaxoCell. (Vortrag)Regions4PerMed-Workshop, 28.4.2021, online
Köhl U. Innovation und Versorgung - Ein Widerspruch für Spitzenmedizin in Deutschland? (Vortrag)Parlamentarische Veranstaltung »Neue Strategien in der Onkologie«, 11.5.2021, online
Köhl U. Perspektiven der CAR-T-Zell-Technologie in der Krebstherapie. (Vortrag) Colloquium der Universität Potsdam, 19.5.2021, online
Köhl U. CAR NK cells as an “off the shelf” immunotherapy. (Vortrag) 10. Annual Conference of SSBMT, 28.5.2021, online
Köhl U. AR NK Cells: Can they compete with CAR-T cell therapy? (Vortrag) EHA-Congress 2021, 9.-17.6.2021, online
Köhl U. New cell types e.g. NK, universal CAR-T. (Vortrag) ESMO-Virtual Advanced Course, 25.-26.6.2021, online
Köhl U. CAR NK Cells: Can they compete with CAR T cell therapy? (Vortrag) DKFZ-Conference »Innate Cellular Therapy«, 22.7.2021, online
Köhl U. CAR NK Cells: Can they compete with CAR T cell therapy? (Vortrag) Lund-University Seminar Series, 6.9.2021, online
Köhl U. Manufacturing and quality control of CAR T and CAR NK cells. (Vortrag)54. Jahrestagung DGTI, 22.-24.9.2021, online
Köhl U. How to rapidly move cell-based therapies from bench to bedside. (Vortrag) Jahrestagung DPhG, 28.9.-2.10.2021, online
Köhl U. CAR-T-Zell- und Gentherapien. (Vortrag) Onco-Live, 30.9.2021, online
Köhl U. Medikamente und Therapien von morgen. (Vortrag) Industry's Hidden Champions Conference, 5.10.201, Leipzig
Köhl U. CAR effector cells in immuno oncology. (Vortrag)Brno Oncology Day, 14.-16.10.2021, Brno, Tschechien
Köhl U. Controversy: are NK-CAR cells as effective as CAR-T-cells? Yes. (Vortrag) 6. Congress on COSTEM, 21.-24.10.2021, online
Köhl U. Automatization & robotization of manufactory CAR-T cells. (Vortrag)5. Zelltherapie-Symposium UKH, 5.-6.11.2021, Heidelberg
Köhl U. Zelltherapien für Immunerkrankungen. (Vortrag)Tag der Immunforschung, 12.11.2021, online
Köppen J, Gnoth K, Piechotta A, Geißler S, Schilling S, Schulze A. Unmask amyloid deposits – and how to get rid of them! Student Retreats des Graduiertenkollegs RTG2467, Mai 2021, Online
Kuhlmeier D, Schultz C, Gjurova B, Schönfelder J. Non-invasive detection of infections via breath analysis - Visions and challenges. (Vortrag) Conference on Molecular Diagnostics 2021, Moskau, online
Kuhlmeier D. Vorstellung Fraunhofer IZI. Innovationsforum Aktive Mikrofluidische Separation, 23.9.2021
Lehmann J. Neue Therapieansätze für CED. Tag der Immunforschung, 12.11.2021, online
Löffler D, Weirauch U, Greiser S, Rade M, Reiche K, Kunz M, Blumert C. Spatial transcriptomes as readouts for next-generation cancer models. EACR Goodbye Flat Biology, 5.-6.10.2021, online
Mitzner S. Herausforderung septischer Schock – Hintergrund und praktische Aspekte für den Alltag. 13. Jahrestagung der Dt .Gesellschaft für Nephrologie, 23.-26.9.2021, Rostock
Müller C, Köhl U, Lehmann J. Humanized mouse models in oncology research for preclinical studies. Cancer Research & Oncology 2021, online
Rade M, Schramm S, Böhlen S, Neuhaus V, Löffler D, Blumert C, Dehmel S, Sewald K, Reiche K. A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation. Leipzig Immune ONcology (LION) Conference 2021, 9.-10.11.2021, online
Salti H, Kramer L, Nelz SC, Lorenz M, Schwerdt D, Mitzner S, Wasserkort R. Dezellularisierung von Präzisionsschnitten aus Rattennieren - Anwendung physikalischer und chemischer Methoden. 13. Jahrestagung der Deutschen Gesellschaft für Nephrologie, 23.-26.9.2021, Rostock
Salti H, Kramer L, Nelz SC, Lorenz M, Schwerdt D, Mitzner S, Wasserkort R. Development of humanized 3D kidney tissue models from decellularized rat precision-cut kidney slices. 6th World Congress of the Tissue Engineering and Regenerative Medicine International Society (TERMIS 2021), 15.-19.11.21, Maastricht, NL
Schaffert A, Krieg L, Weiner J, Schlichting R, Ueberham E, Karkossa I, Bauer M, Landgraf K, Junge K M, Wabitsch M, Lehmann J, Escher B I, Zenclussen A C, Körner A, Blüher M, Heiker J T, Bergen v M, Schubert K. Emerging substitutes of BPA cause inflammation-like state and impaired insulin sensitivity in differentiating human adipocytes. EUROTOX 2021, 26.9.-1.10.2021, online
Schenk M, Rahfeld J-U, Blaudszun A-R, Linnert M, Stubbs M T. Development of antibody 5G4 against pathological α-synuclein for treatment of Parkinson’s disease. (Poster) Instruct-ERIC course on macromolecular X-ray, electron and neutron crystallography, 29.6.-6.7.2021, online
Schenk M, Rahfeld J-U, Blaudszun A-R, Linnert M, Stubbs M T. Development of antibody 5G4 against pathological α-synuclein for treatment of Parkinson’s disease. (Vortrag) 23rd Heart of Europe Bio-Crystallography Meeting, 16.-17.9.2021, online
Schönfelder J, Steppert I, Gjurova B, Schultz C, Bangen LM, Kuhlmeier D. In-vitro differentiation of bacterial species and several antibiotic resistant E. coli strains by MCC-IMS. (Vortrag)Conference of International Society of Ion Mobility Spectrometry - ISIMS 2021, 26.-30.7.2021, online
Steppert I, Schönfelder J, Kuhlmeier D. MCC-IMS als schnelles Screening-Verfahren für Infektionserreger. (Vortrag) 8. IMS-Anwendertreffen, 17.-19.3.2021, online
Szardenings M, Delaroque N, Fischer M, Kern K, Puder M, Ramirez Caballero L, Wehrmann D, Ehrentreich-Förster E, Zürner S, Braumann UD. PERSONALIZED IMMUNE DIAGNOSTICS: IMMUNOME MAPPING FOR COVID-19 AND ENDEMIC CORONA VIRUSES. Molecular Diagnostics 2021, 9.-11.11.2021, Moskau, online
Szardenings M. SARS-CoV-2: immunomics after disease and vaccination and analyses of epitopes for corona spec. LiNS - omics applications, Leipzig, 9.-12.9.2021
Tradler T. Fraunhofer IZI at a glance. Advanced Therapy Showcase in Tokyo, 21.1.2021
Tradler T. Saxony! - Building Europe`s Cell and Gene Therapy Hub. LSX World Congress Virtual 2021, 1.-5.2.2021, online
Tradler T. Company Presentation - Fraunhofer IZI at a glance/Saxocell. Cell & Gene Meeting on the Mediterranean, 6.-9.4.2021
Tradler T. Kooperationsmöglichkeiten mit dem Fraunhofer IZI. Unternehmer Pitch - Regional, 16.4.2021
Tradler T. Krebs – den Stier bei den Hörnern packen! Neue Therapie- und Versorgungsperspektiven in der Onkologie. (Vortrag) 16. Nationale Branchenkonferenz Gesundheitswirtschaft 2021, 4.6.2021, Rostock, online
Tradler T. Fraunhofer IZI as an exemplary infrastructure with high regional impact for personalised medicine. Regions 4 PerMed »Innovation Flow in the Healthcare«, 16.11.2021, online
Tradler T. From a TTO’s standpoint: finding the good match in asset transactions. BioFIT 2021 Digital, 7.12.2021, online
Tretbar S. Customized Micellar Nanocarriers for mRNA Transfection of Immune Cells. Fraunhofer CIMD Winter School, 5.-8.10.2021, online
Uhlig N, Eberlein V, Issmail L, Schulz I, Peter AS, Roth E, Schulz SR, Fraedrich K, Steinmetz T, Damm D, Hauke M, Richel E, Mueller-Schmucker S, Habenicht K, Pöhlmann S, McKay PF, Shattock RJ, Wölfel R, Eichler J, Schuh W, Neipel F, Ensser A, Mielenz D, Tenbusch M, Winkler TH, Überla K, Jäck H-M, Grunwald T. Efficacy of novel neutralizing antibodies against SARS-CoV-2 infection in ACE2 transgenic mouse model. 30th Annual Meeting of the Society for Virology, 25.-28.3.2021, online
Walcher L. Electron beam irradiation-based inactivation of chimeric antigen receptor (CAR) NK-92 cells for therapy of acute myeloid leukemia (AML). 18th CIMT Annual Meeting 2021, 10.5.2021
Westphal C. Qualität der Eskalationsvermeidung bei chronischer Niereninsuffizienz: Ergebnisse einer retrospektiven Längsschnittanalyse. 13. Jahrestagung der Deutschen Gesellschaft für Nephrologie, 23.-26.9.2021, Rostock