Fraunhofer-Institut für Zelltherapie und Immunologie IZI
Fraunhofer-Institut für Zelltherapie und Immunologie IZI

Jahresbericht 2024/25

Publikationen

Originalpublikationen

  • Alb M, Reiche K, Rade M, Sewald K, Loskill P, Cipriano M, Maulana TI, van der Meer AD, Weener HJ, Clerbaux LA, Fogal B, Patel N, Adkins K, Lund E, Perkins E, Cooper C, van den Brulle J, Morgan H, Rubic-Schneider T, Ling H, DiPetrillo K, Moggs J, Köhl U, Hudecek M. Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept. J Immunotoxicol. 2024, 21 (sup1): S13-S28. doi: 10.1080/1547691X.2024.2345158. Epub 2024 Dec 10.
  • Aldehoff A S, Türkowsky D, Lohmann P, Homsi M N, Rolle-Kampczyk U, Ueberham E, Lehmann J, Bergen M von, Jehmlich N, Haange S-B. Revealing novel protein interaction partners of glyphosate in Escherichia coli. Environ Int. 2025: 195, 109243. doi: 10.1016/j.envint.2024.109243. Epub 2024 Dec 25.
  • Aleksandrova K, Leise J, Priesner C, Aktas M, Apel M, Assenmacher M, Bürger I, Richter A, Altefrohne P, Schubert C, Holzinger A, Barden M, Bezler V, von Bergwelt-Baildon M, Borchmann P, Goudeva L, Glienke W, Arseniev L, Esser R, Abken H, Koehl U. Automated manufacturing and characterization of clinical grade autologous CD20 CAR T cells for the treatment of patients with stage III/IV melanoma. Front Immunol. 2024, 15: 1328368. doi: 10.3389/fimmu.2024.1328368. eCollection 2024.
  • Altattan B, Ullrich J, Mattig E, Poppe A, Martins R, Bier F. Direct TAMRA-dUTP labeling of M. tuberculosis genes using loop-mediated isothermal amplification (LAMP). Sci Rep. 2024, 14(1): 5611. doi: 10.1038/s41598-024-55289-x
  • Araujo AE, Bentler M, Garmendia XP, Kaleem A, Fabian C, Morgan M, Hacker UT, Büning H. Adeno-associated virus vectors - a target of cellular and humoral immunity - are expanding their reach toward hematopoietic stem cell modification and immunotherapies. Hum Gene Ther. 2024, 35 (17-18): 586-603. doi: 10.1089/hum.2024.114
  • Barden M, Elsenbroich P R, Haas V, Ertelt M, Pervan P, Velas L, Gergely B, Szöőr Á, Harrer D C, Bezler V, Holzinger A, Friis R U W, Vereb G, Schütz G J, Schoeder C T, Hombach A A, Abken H. Integrating binding affinity and tonic signaling enables a rational CAR design for augmented T cell function. J Immunother Cancer. 2024, 12 (12): e010208. doi: 10.1136/jitc-2024-010208
  • Bauer M, Jäkel N, Wilfer A, Haak A, Eszlinger M, Kelemen K, Haemmerle M, Al-Ali HK, Seliger B, Wickenhauser C. Prognostic impact of the bone marrow tumor microenvironment, HLA-I and HLA-Ib expression in MDS and CMML progression to sAML. Oncoimmunology. 2024, 13 (1): 2323212. doi: 10.1080/2162402X.2024.2323212. eCollection 2024.
  • Bauer M, Monecke A, Hackl H, Wilfer A, Jaekel N, Bläker H, Al-Ali HK, Seliger B, Wickenhauser C. Association of immune evasion in myeloid sarcomas with disease manifestation and patients' survival. Front Immunol. 2024, 15: 1396187. doi: 10.3389/fimmu.2024.1396187. eCollection 2024.
  • Bauer M, Schöbel C-M, Wickenhauser C, Seliger B, Jasinski-Bergner S. Deciphering the role of alternative splicing in neoplastic diseases for immune-oncological therapies. Front Immunol. 2024, 15: 1386993. doi: 10.3389/fimmu.2024.1386993. eCollection 2024.
  • Bauser M, Einsele H, Löffler J, Hudecek M, Seif M. Engineering chimeric antigen receptor-natural killer cells targeting fungal infections using the non-viral Sleeping Beauty transposon system. J Vis Exp. 2024, 212. doi: 10.3791/67424
  • Benedyk-Machaczka M, Mydel P, Mäder K, Kaminska M, Taudte N, Naumann M, Kleinschmidt M, Sarembe S, Kiesow A, Eick S, Buchholz M. Preclinical validation of MIN-T: a novel controlled-released formulation for the adjunctive local application of minocycline in periodontitis. Antibiotics (Basel). 2024, 13 (11): 1012. doi: 10.3390/antibiotics13111012
  • Beneke V, Grieger KM, Hartwig C, Müller J, Sohn K, Blaudszun A-R, Hilger N, Schaudien D, Fricke S, Braun A, Sewald K, Hesse C. Homeostatic T helper 17 cell responses triggered by complex microbiota are maintained in ex vivo intestinal tissue slices. Eur J Immunol. 2024, 8: e2350946. doi: 10.1002/eji.202350946. Epub 2024 May 19.
  • Besecke J K, Kenner L, Poremba A, Schönfelder J, Teichmann T, Thoma M, Grunwald T, Hauff E von, König U, Poppe B, Schopf S. Method for the use of polymer beads as dosimeters for low-energy electron irradiation. Front. Phys. 2024, 12: 1490048. doi: 10.3389/fphy.2024.1490048
  • Bexte T, Botezatu L, Miskey C, Gierschek F, Moter A, Wendel P, Reindl LM, Campe J, Villena-Ossa JF, Gebel V, Stein K, Cathomen T, Cremer A, Wels WS, Hudecek M, Ivics Z, Ullrich E. Engineering of potent CAR NK cells using non-viral Sleeping Beauty transposition from minimalistic DNA vectors. Mol Ther. 2024, 32 (7): 2357-2372. doi: 10.1016/j.ymthe.2024.05.022. Epub 2024 May 14.
  • Blaess M, Csuk R, Schätzl T, Deigner H-P. Elongation of very long-chain fatty acids (ELOVL) in atopic dermatitis and the cutaneous adverse effect AGEP of drugs. Int J Mol Sci. 2024, 25 (17):9344. doi: 10.3390/ijms25179344
  • Buniatian GH, Schwinghammer U, Tremmel R, Cynis H, Weiss TS, Weiskirchen R, Lauschke VM, Youhanna S, Ramos I, Valcarcel M, Seferyan T, Rahfeld J-U, Rieckmann V, Klein K, Buadze M, Weber V, Kolak V, Gebhardt R, Friedman SL, Müller UC, Schwab M, Danielyan L. Consequences of amyloid-β deficiency for the liver. Adv Sci (Weinh). 2024, 11 (18): e2307734. doi: 10.1002/advs.202307734. Epub 2024 Mar 2.
  • Comoli P, Pentheroudakis G, Ruggeri A, Koehl U, Lordick F, Mooyaart JE, Hoogenbom JD, Urbano-Ispizua A, Peters S, Kuball J, Kröger N, Sureda A, Chabannon C, Haanen J, Pedrazzoli P. Current strategies of cell and gene therapy for solid tumors: results of the joint international ESMO and CTIWP-EBMT survey. Ann Oncol. 2024, 35 (4): 404-406. doi: 10.1016/j.annonc.2023.12.009
  • Derraz B, Breda G, Kämpf C, Baenke F, Cotte F, Reiche K, Köhl U, Kather JN, Eskenazy D, Gilbert S. New regulatory thinking is needed for AI-based personalised drug and cell therapies in precision oncology. NPJ Precis Oncol. 2024, ;8 (1): 23. doi: 10.1038/s41698-024-00517-w
  • Dinh-Le T, Escobar J, Poisson L, Adkins K, Jornet Culubret M, Scheller L,  Brulle J van den, Hudecek M, Drake D R III, Alb M, Luna E. Identifying CD19-targeted CAR-T cell immune pathways in an in vitro human immune mimetic cytokine release assay. J Immunotoxicol. 2024, 21 (sup1): S29-S37. doi: 10.1080/1547691X.2024.2378729. Epub 2024 Dec 10.
  • Eberlein V, Rosencrantz S, Finkensieper J, Besecke JK, Mansuroglu Y, Kamp J-C, Lange F, Dressmann J, Schopf S, Hesse C, Thoma M, Fertey J, Ulbert S, Grunwald T. Mucosal immunization with a low-energy electron inactivated respiratory syncytial virus vaccine protects mice without Th2 immune bias. Front Immunol. 2024, 15: 1382318. doi: 10.3389/fimmu.2024.1382318. eCollection 2024.
  • Fandrei D, Seiffert S, Rade M, Rieprecht S, Gagelmann N, Born P, Wiemers T, Weidner H, Kreuz M, Schassberger T, Kossmann J, Mangold M, Furst D, Fischer L, Baber R, Heyn S, Wang SY, Bach E, Hoffmann S, Metzeler KH, Herlling M, Jentzsch M, Franke G-N, Köhl U, Friedrich M, Boldt A, Reiche K, Platzbecker U, Vucinic V, Merz M. Bispecific antibodies as bridging to BCMA CAR-T cell therapy for relapsed/refractory multiple myeloma. Blood Cancer Discov. 2025, 6 (1): 38-54. doi: 10.1158/2643-3230.BCD-24-0118. Epub 2024 Oct 23
  • Fischer L, Grieb N, Born P, Weiss R, Seiffert S, Boldt A, Fricke S, Franz P, Heyn S, Kubasch AS, Baber R, Weidner H, Wang SY, Bach E, Hoffmann S, Ussmann J, Kirchberg J, Hell S, Schwind S, Metzeler KH, Herling M, Jentzsch M, Franke G-N, Sack U, Reiche K, Köhl U, Platzbecker U, Vucinic V, Merz M. Cellular dynamics following CAR T cell therapy are associated with response and toxicity in relapsed/refractory myeloma. Leukemia. 2024, 38 (2): 372-382. doi: 10.1038/s41375-023-02129-y. Epub 2024 Jan 6.
  • Forni L, Aucella F, Bottari G, Büttner S, Cantaluppi V, Fries D, Kielstein J, Kindgen-Milles D, Krenn C, Kribben A, Meiser A, Mitzner S, Ostermann M, Premuzic V, Rolfes C, Scharf C, Schunk S, Molnar Z, Zarbock A. Hemoadsorption therapy for myoglobin removal in rhabdomyo­lysis: consensus of the hemo­adsorption in rhabdomyolysis task force. BMC Nephrol. 2024, 25 (1): 247. doi: 10.1186/s12882-024-03679-8
  • Frielitz-Wagner I V, Mattutat J, Frielitz F S, Scheuermann K, Gesing J, Marheineke D, Löffler D, Kiess W, Körner A. Diurnal rythm of Nampt is gender and weight dependent. Obes Res Clin Pract. 2024, 18 (3): 181-188. doi: 10.1016/j.orcp.2024.06.005. Epub 2024 Jul 3.
  • Funcke S, Schmidt G, Bergholz A, Argente Navarro P, Azparren Cabezón G, Barbero-Espinosa S, Diaz-Cambronero O, Edinger F, García-Gregorio N, Habicher M, Klinkmann G, Koch C, Kröker A, Mencke T, Moral García V, Zitzmann A, Lezius S, Pepić A, Sessler DI, Sander M, Haas SA, Reuter DA, Saugel B. Cardiac index-guided therapy to maintain optimised post­induction cardiac index in high-risk patients having major open abdominal surgery: the multicentre randomised iPEGASUS trial. Br J Anaesth. 2024, 133 (2): 277-287. doi: 10.1016/j.bja.2024.03.040. Epub 2024 May 26.
  • Funk C, Uhlig N, Ruzsics Z, Baur F, Peindl M, Nietzer S, Epting K, Vacun G, Dandekar G, Botteron C, Werno C, Grunwald T, Bailer SM. TheraVision: engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1. Mol Ther Oncol. 2024, 32 (1): 200784. doi: 10.1016/j.omton.2024.200784. eCollection 2024 Mar 21.
  • Gege C, Hahn F, Wangen C, Häge S, Herrmann A, Uhlig N, Eberlein V, Issmail L, Klopfleisch R, Grunwald T, Marschall M, Kohlhof H, Vitt D. Synthesis and characterization of DHODH inhibitors based on the vidofludimus scaffold with pronounced anti-SARS-CoV-2 activity. ChemMedChem. 2024, 19 (19): e202400292. doi: 10.1002/cmdc.202400292. Epub 2024 Aug 6.
  • Gehrke L, Gonçalves V D R, Andrae D, Rasko T, Ho P, Einsele H, Hudecek M, Friedel S R. Current non-viral-based strategies to manufacture CAR-T cells. Int J Mol Sci. 2024, 25 (24): 13685. doi: 10.3390/ijms252413685
  • Ghazizadeh E, Naseri Z, Deigner H-P, Rahimi H, Altintas Z. Approaches of wearable and implantable biosensor towards of developing in precision medicine. Front Med (Lausanne). 2024, 11: 1390634. doi: 10.3389/fmed.2024.1390634. eCollection 2024.
  • Gierschek F, Schlueter J, Kühnel I, Feigl FF, Schmiedel D, Prüfer M, Buchinger L, Cerwenka A, Cappel C, Huenecke S, Köhl U, Wels WS, Ullrich E. Empowering natural killer cells to combat acute myeloid leukemia: perspective on CAR-NK cell therapy. Transfus Med Hemother. 2024, 52 (1): 42-60. doi: 10.1159/000540962. eCollection 2025 Feb.
  • Gnoth K, Bär JW, Rosche F, Rahfeld J-U, Demuth H-U. Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme. PLoS One. 2024, 19 (4): e0289239. doi: 10.1371/journal.pone.0289239. eCollection 2024.
  • Grahnert A, Seiffert S, Wenk K, Schmiedel D, Boldt A, Vucinic V, Merz M, Platzbecker U, Klemann C, Köhl U, Friedrich M. Evaluation of anti-CAR linker mAbs for CAR T monitoring after BiTEs/bsAbs and CAR T-cell pretreatment. Biomedicines. 2024, 12 (8): 1641. doi: 10.3390/biomedicines12081641
  • Haller K, Doss S, Sauer M. In vitro hepatotoxicity of routinely Used opioids and sedative drugs. Curr Issues Mol Biol. 2024, 46 (4): 3022-3038. doi: 10.3390/cimb46040189
  • Hassan L, Bedir A, Kraus FB, Ostheimer C, Vordermark D, Mikolajczyk R, Seliger B, Medenwald D. Correlation of increased soluble tumor necrosis factor receptor 1 with mortality and dependence on treatment in non-small-cell lung cancer patients: a longitudinal cohort study. Cancers (Basel). 2024, 16 (3): 525. doi: 10.3390/cancers16030525
  • Herrmann A, Gege C, Wangen C, Wagner S, Kögler M, Cordsmeier A, Irrgang P, Ip W-H, Weil T, Hunszinger V, Groß R, Heinen N, Pfaender S, Reuter S, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Grunwald T, Hietel B, Cynis H, Münch J, Sparrer K M J, Ensser A, Tenbusch M, Dobner T, Vitt D, Kohlhof H, Hahn F. Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity. Antiviral Res. 2024, 231: 106008. doi: 10.1016/j.antiviral.2024.106008. Epub 2024 Sep 19.
  • Hinestrosa C A, Fuchs J, Denecke T, Storch C, Dreyer A, Kuthning A, Reinhardt M, Rio Bartulos C, Wiggermann P, Busse H, Moche M. In vivo revascularization and tissue effects of uterine artery embolization with starch micro­spheres in sheep. Clin Hemorheol Microcirc. 2024, 88 (s1): S69-S84. doi: 10.3233/CH-248106
  • Höfling C, Donkersloot P, Ulrich L, Burghardt S, Opitz M, Geissler S, Schilling S, Cynis H, Michalski D, Roßner S. Dipeptidyl peptidase 4 deficiency improves survival after focal cerebral ischemia in mice and ameliorates microglia activation and specific inflammatory markers. Neurobiol Dis. 2024, 201: 106671. doi: 10.1016/j.nbd.2024.106671. Epub 2024 Sep 16.
  • Höfling C, Ulrich L, Burghardt S, Donkersloot P, Opitz M, Geissler S, Schilling S, Cynis H, Michalski D, Roßner S. Focal cerebral ischemia induces expression of glutaminyl cyclase along with downstream molecular and cellular inflammatory responses. Cells. 2024, 13 (17):1412. doi: 10.3390/cells13171412
  • Jaber M, Schmidt J, Kalkhof S, Gerstenfeld L, Duda G N, Checa S. OMIBONE: Omics-driven computer model of bone regeneration for personalized treatment. Bone. 2025 Jan:190:117288. doi: 10.1016/j.bone.2024.117288. Epub 2024 Oct 18.
  • Jung-Fittkau J, Diebold J, Kruse A, Deigner H-P, Schmidt MS. Measurement of the reaction enthalpy of CO2 in aqueous solutions with thermographic and gravimetric methods. Sci Rep. 2024, 14 (1): 10373. doi: 10.1038/s41598-024-61242-9
  • Kern K, Santa-Ardharnpreecha S, Delaroque N, Dölle-Bierke S, Treudler R, Ehrentreich-Förster E, Rothkopf I, Worm M, Szardenings M. Heat treatment of hazelnut allergens monitored by polyclonal sera and epitope fingerprinting. Foods. 2024, 13 (23): 3932. doi: 10.3390/foods13233932
  • Klinkmann G, Doss F, Doss S, Schwarz A, Reichert S, Reuter DA, Selleng K, Thiele T, Mitzner S, Altrichter J. Purified granulocyte concentrates from buffy coats with extended storage time. Transfus Med Hemother. 2024, 51 (6): 383-392. doi: 10.1159/000537698. eCollection 2024 Dec.
  • Köppen J, Kleinschmidt M, Morawski M, Rahfeld J-U, Wermann M, Cynis H, Hegenbart U, Daniel C, Roßner S, Schilling S, Schulze A. Identification of isoaspartate-­modified transthyretin as potential target for selective immunotherapy of transthyretin amyloidosis. Amyloid. 2024, 31 (3): 184-194. doi: 10.1080/13506129.2024.2358121. Epub 2024 May 27.
  • Körtge A, Breitrück A, Doß S, Hofrichter J, Nelz S-C, Krüsemann H, Wasserkort R, Fitzner B, Hecker M, Mitzner S, Zettl UW. The utility of miniaturized adsorbers in exploring the cellular and molecular effects of blood purification - a pilot study with a focus on immunoadsorption in multiple sclerosis. Int J Mol Sci. 2024, 25 (5): 2590. doi: 10.3390/ijms25052590
  • Krause JL, Engelmann B, Schaepe SS, Rolle-Kampczyk U, Jehmlich N, Chang H-D, Slanina U, Hoffmann M, Lehmann J, Zenclussen AC, Herberth G, Bergen Mv. DSS treatment does not affect murine colonic microbiota in absence of the host. Gut Microbes. 2024, 16 (1): 2297831. doi: 10.1080/19490976.2023.2297831. Epub 2024 Jan 2.
  • Lawlor A, Beyer K, Russell B, Steinbeisser C, Bjartell A, De Meulder B, Omar MI, Hulsen T, Butler J, N'Dow J, Gómez Rivas J, Gandaglia G, Nicoletti R, Sakalis V, Smith EJ, Maass M, Zong J, Fullwood L, Abbott T, Tafreshiha A, Papineni K, Snijder R, Horgan D, Seager S, Evans-Axelsson S, Ribal MJ, Roobol MJ, Van Hemelrijck M; PIONEER Consortium. PIONEER big data platform for prostate cancer: lessons for advancing future real-world evidence research. Nat Rev Urol. 2025, 22 (2): 116-124. doi: 10.1038/s41585-024-00925-4. Epub 2024 Sep 9.
  • Lehmann S, Retschlag U, Oberbach A. Visceral fat mass dynamics in a 2-year randomized STrength versus ENdurance training trial in people with obesity. Diabetes Obes Metab. 2024, 26 (9): 4087-4099. doi: 10.1111/dom.15767. Epub 2024 Jul 16.
  • Li H, Wilhelm M, Baumbach CM, Hacker MC, Szardenings M, Rischka K, König A, Schulz-Kornas E, Fuchs F, Simon JC, Lethaus B, Savkovic V. Laccase-treated polystyrene surfaces with caffeic acid, dopamine, and L-3,4-Dihydroxyphenylalanine substrates facilitate the proliferation of melanocytes and embryonal carcinoma cells NTERA-2. Int J Mol Sci. 2024, 25 (11): 5927. doi: 10.3390/ijms25115927
  • Li J, Hietel B, Brunk M G K, Reimers A, Willems C, Groth T, Cynis H, Adelung R, Schütt F, Sacher WD, Poon JKS. 3D-printed microstructured alginate scaffolds for neural tissue engineering. Trends Biotechnol. 2025, 43 (2): 447-461. doi: 10.1016/j.tibtech.2024.10.013. Epub 2024 Dec 10.
  • Lomelí-Ortega CO, Barajas-Sandoval D, Ramírez-Sánchez I, Martínez-Villalobos JM, Leptihn S, Quiroz-Guzmán E. Complete genome sequence of Vibrio diabolicus bacteriophage vB_Vc_SrVc2 and its efficacy as prophylactic phage therapy. Virology. 2025, 602: 110322. doi: 10.1016/j.virol.2024.110322. Epub 2024 Nov 28.
  • Manohar P, Loh B, Nachimuthu R, Leptihn S. Phage-antibiotic combinations to control Pseudomonas aeruginosa-Candida two-species biofilms. Sci Rep. 2024, 14 (1): 9354. doi: 10.1038/s41598-024-59444-2
  • Manohar P, Loh B, Turner D, Tamizhselvi, Mathankumar M, Elangovan N, Nachimutu R, Leptihn S. In vitro and in vivo evaluation of the biofilm-degrading Pseudomonas phage Motto, as a candidate for phage therapy. Front Microbiol. 2024, 15: 1344962. doi: 10.3389/fmicb.2024.1344962. eCollection 2024.
  • Matúš D, Post W B, Groß V E, Kuhn C K, Knierim A B, Kuhn C K, Fiedler F, Tietgen D B, Schön J L, Schöneberg T, Prömel S. The N terminus-only (trans) function of the Adhesion GPCR Latrophilin-1 controls multiple processes in reproduction of C. elegans. G3 (Bethesda). 2024, 14 (11): jkae206. doi: 10.1093/g3journal/jkae206
  • Maulana TI, Teufel C, Cipriano M, Roosz J, Lazarevski L, van den Hil FE, Scheller L, Orlova V, Koch A, Hudecek M, Alb M, Loskill P. Breast cancer-on-chip for patient-specific efficacy and safety testing of CAR-T cells. Cell Stem Cell. 2024, 31 (7): 989-1002.e9. doi: 10.1016/j.stem.2024.04.018. Epub 2024 May 15.
  • Mazein A, Shoaib M, Alb M, Sakellariou C, Sommer C, Sewald K, Reiche K, Gogesch P, Roser L A, Ortega Iannazzo S, Sheth S, Schiffmann S, Waibler Z, Neuhaus V, Dehmel S, Satagopama V, Schneider R, Ostaszewski M, Gu W. Using interactive platforms to encode, manage and explore immune-relatedadverse outcome pathways. J Immunotoxicol. 2024, 21 (sup1): S5-S12. doi: 10.1080/1547691X.2024.2345154. Epub 2024 Dec 10.
  • Merz M, Dima D, Hashmi H, Ahmed N, Stölzel F, Holderried T A W, Fenk R, Müller F, Tovar N, Oliver-Cáldes A, Rathje K, Davis J A, Fandrei D, Vucinic V, Kharboutli S, Baermann B-N, Ayuk F, Platzbecker U, Albici A-M, Schub N, Schmitz F, Shune L, Khouri J, Anwer F, Raza S, McGuirk J, Mahmoudjafari Z, Green K, Khandanpour C, Teichert M, Jeker B, Hoffmann M, Kröger N, von Tresckow B, Fernández de Larrea C, Pabst T, Abdallah A-O, Gagelmann N. Bispecific antibodies targeting BCMA or GPRC5D are highly effective in relapsed myeloma after CAR T-cell therapy. Blood Cancer J. 2024, 14 (1): 214. doi: 10.1038/s41408-024-01197-2
  • Mestermann K, Garitano-Trojaola A, Hudecek M. Accelerating CAR‑T cell therapies with small‑molecule inhibitors. BioDrugs. 2025, 39 (1): 33-51. doi: 10.1007/s40259-024-00688-9. Epub 2024 Nov 26.
  • Möhrke L, Hauer M, Gericke A, Breitrück A, Kreikemeyer B, Henke K-M. Copper coatings for antibiotics reduction in fattening livestock. J Therm Spray Tech 2024, 33 (2-3), 771-785. doi: 10.1007/s11666-024-01742-2
  • Mollenkopf P, Prascevic D, Glaser M, Smith DM, Schnauß J. A science friction story: molecular interactions in semiflexible polymer networks. Advanced Materials Interfaces 2024, 11 (5), article 202300623. doi: 10.1002/admi.202300623
  • Müller-Graf F, Wrede D, Bork L, Klinkmann G, Flick M, Reuter D A, Zitzmann A R, Böhm S H, Reuter S. Quantification of video sequences of the microcirculation: a comparison between automated analysis using analysis manager and manual analysis using Capillary Mapper. Microcirculation. 2024, 31 (8): e12890. doi: 10.1111/micc.12890. Epub 2024 Sep 26.
  • Navarro S, Moukheiber C, Inogés Sancho S, Ruiz Guillén M, López-Díaz de Cerio A, Sanges C, Tanaka T, Arnould S, Briones J, Dolstra H, Hudecek M, Choudhary R, Schapitz I, Juan M, Worel N, Ammar D, Luu M, Müller M, Schroeder B, Negre H, Franz P. Optimizing CAR-T treatment: A T2EVOLVE guide to raw and starting material selection. Mol Ther. 2024, S1525-0016(24)00744-5. doi: 10.1016/j.ymthe.2024.11.017. Online ahead of print.
  • Ng DP, Simonson PD, Tárnok A, Lucas F, Kern W, Rolf N, Bogdanoski G, Green C, Brinkman RR, Czechowska K. Recommendations for using artificial intelligence in clinical flow cytometry. Cytometry B Clin Cytom. 2024, 106 (4): 228-238. doi: 10.1002/cyto.b.22166. Epub 2024 Feb 26.
  • Nguyen N T T, Müller R, Briukhovetska D, Weber J, Feucht J, Künkele A, Hudecek M, Kobold S. The spectrum of CAR cellular effectors: modes of action in anti-tumor immunity. Cancers (Basel). 2024, 16 (14): 2608. doi: 10.3390/cancers16142608
  • Niarakis A, Laubenbacher R, An G, Ilan Y, Fisher J, Flobak Å, Reiche K, Rodríguez Martínez M, Geris L, Ladeira L, Veschini L, Blinov ML, Messina F, Fonseca LL, Ferreira S, Montagud A, Noël V, Marku M, Tsirvouli E, Torres M M, Harris LA, Sego TJ, Cockrell C, Shick AE, Balci H, Salazar A, Rian K, Abdelmonem Hemedan A, Esteban-Medina M, Staumont B, Hernandez-Vargas E, Martis B, Madrid-Valiente A, Karampelesis P, Sordo Vieira L, Harlapur P, Kulesza A, Nikaein N, Garira W, Malik Sheriff RS, Thakar J, Tran V D T, Carbonell-Caballero J, Safaei S, Valencia A, Zinovyev A, Glazier JA. Immune digital twins for complex human pathologies: applications, limitations, andchallenges. NPJ Syst Biol Appl. 2024, 10 (1): 141. doi: 10.1038/s41540-024-00450-5
  • Nikolits I, Chariyev-Prinz F, Egger D, Liebner F, Mytzka N, Kasper C. Characterization of MSC growth, differentiation, and EV production in CNF hydrogels under static and dynamic cultures in hypoxic and normoxic conditions. Bioengineering (Basel). 2024, 11 (10): 1050. doi: 10.3390/bioengineering11101050
  • Ochmann MT, Miskey C, Botezatu L, Sandoval-Villegas N, Diem T, Ivics Z. A novel hyperactive variant of the Sleeping Beauty transposase facilitates non-viral genome engineering. Mol Ther Nucleic Acids. 2024, 35 (4): 102381. doi: 10.1016/j.omtn.2024.102381. eCollection 2024 Dec 10.
  • Ohlinger J, Vordermark D, Ostheimer C, Bache M, Tzschoppe T, Demircan K, Schomburg L, Medenwald D, Seliger B. Change in the serum selenium level of patients with non-metastatic and metastatic non-small cell lung cancer (NSCLC) during radiotherapy as a predictive factor for survival. Strahlenther Onkol. 2024. doi: 10.1007/s00066-024-02276-w. Online ahead of print.
  • Oliveira da Rocha G H, Müller C, Przybylski-Wartner S, Schaller H, Riemschneider S, Lehmann J. AhR-Induced anti-inflammatory effects on a caco-2/THP-1 co-culture model of intestinal inflammation are mediated by PPARγ. Int J Mol Sci. 2024, 25 (23): 13072. doi: 10.3390/ijms252313072
  • Pardi N, Ivics Z. An LNP-CRISPR gene editing drug demonstrates efficacy and safety in hereditary angioedema patients following in vivo administration. J Allergy Clin Immunol. 2024, 154 (2): 272-274. doi: 10.1016/j.jaci.2024.06.011. Epub 2024 Jun 24.
  • Polonschii C, Rosu-Hamzescu M, Sorin D, Oloumi A, Ursu V-D, Szardenings M, Kern K, El Salhi AE. Point-of-care personalized rapid diagnosis of allergies using peptide epitopes and SPR multiplexed detection. Sensors & Actuators B, Chemicals. 2024,  418, 136359. doi: 10.1016/j.snb.2024.136359
  • Rade M, Grieb N, Weiss R, Sia J, Fischer L, Born P, Boldt A, Fricke S, Franz P, Scolnick J, Venkatraman L, Xu S, Kloetzer C, Heyn S, Kubasch AS, Baber R, Wang SY, Bach E, Hoffmann S, Ussmann J, Schetschorke B, Hell S, Schwind S, Metzeler KH, Herling M, Jentzsch M, Franke G-N, Sack U, Köhl U, Platzbecker U, Reiche K, Vucinic V, Merz M. Single-cell multiomic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma. Nat Cancer. 2024 Sep;5(9):1318-1333. doi: 10.1038/s43018-024-00763-8. Epub 2024 Apr 19.
  • Rade M, Kreuz M, Borkowetz A, Sommer U, Blumert C, Füssel S, Bertram C, Löffler D, Otto DJ, Wöller LA, Schimmelpfennig C, Köhl, U, Gottschling A-C, Hönscheid P, Baretton GB, Wirth M, Thomas C, Horn F, Reiche K. A reliable transcriptomic risk-score applicable to formalin-­fixed paraffin-­embedded biopsies improves outcome prediction in localized prostate cancer. Mol Med. 2024, 30 (1): 19. doi: 10.1186/s10020-024-00789-9
  • Reiß F, Kiefer N, Purahong W, Borken W, Kalkhof S, Noll M. Active soil microbial composition and proliferation are directly affected by the presence of biocides from building materials. Sci Total Environ. 2024, 912: 168689. doi: 10.1016/j.scitotenv.2023.168689. Epub 2023 Nov 23.
  • Reiß F, Kiefer N, Reiß P, Kalkhof S, Noll M. Facade eluates affect active and total soil microbiome. Environ Pollut. 2025, ;364 (Pt 1): 125242. doi: 10.1016/j.envpol.2024.125242. Epub 2024 Nov 9.
  • Renner A, Stahringer A, Ruppel KE, Fricke S, Köhl U, Schmiedel D. Development of KoRV-pseudotyped lentiviral vectors for efficient gene transfer into freshly isolated immune cells. Gene Ther. 2024, 31 (7-8): 378-390. doi: 10.1038/s41434-024-00454-0. Epub 2024 Apr 29.
  • Rentschler S, Borgolte M, Csuk R, Laufer S, Deigner H-P. Toward more sustainable enzyme reactions: enhancing kinetics by polydimethylacrylamide implementation. Green Chem., 2024, 26: 1653-1659. doi: 10.1039/D3GC04688E
  • Rentschler S, Doss S, Kaiser L, Weinschrott H, Kohl M, Deigner H-P, Sauer M. Metabolic biomarkers of liver failure in cell models and patient sera: toward liver damage evaluation in vitro. Int J Mol Sci. 2024, 25 (24): 13739. doi: 10.3390/ijms252413739
  • Riester O, Kaiser L, Laufer S, Deigner H-P. Rapid phenotypic antibiotics susceptibility analysis by a 3D printed prototype. Adv Sci (Weinh). 2024, 11 (21): e2308806. doi: 10.1002/advs.202308806. Epub 2024 Mar 26.
  • Riester O, Laufer S, Mertelsmann R, Deigner H-P. Sensors for antibiotics susceptibility testing – recent advances. Adv Sensor Res 2024, 3 (10), article 202400046. doi: 10.1002/adsr.202400046
  • Sandoval-Villegas N, Ivics Z. The best of both worlds: AAV-mediated gene transfer empowered by LNP delivery of Sleeping Beauty transposase for durable transgene expression in vivo. Mol Ther. 2024, 32 (10): 3211-3214. doi: 10.1016/j.ymthe.2024.09.002. Epub 2024 Sep 25.
  • Schäfer TE, Knol LI, Haas FV, Hartley A, Pernickel SCS, Jády A, Finkbeiner MSC, Achberger J, Arelaki S, Modic Ž, Schröer K, Zhang W, Schmidt B, Schuster P, Haferkamp S, Doerner J, Gebauer F, Ackermann M, Kvasnicka H-M, Kulkarni A, Bots STF, Kemp V, Hawinkels LJAC , Poetsch AR, Hoeben RC, Ehrhardt A, Marchini A, Ungerechts G, Ball CR, Engeland CE. Biomarker screen for efficacy of oncolytic virotherapy in patient-­derived pancreatic cancer cultures. EBioMedicine. 2024, 105: 105219. doi: 10.1016/j.ebiom.2024.105219. Epub 2024 Jun 27.
  • Schätzl T, Todorow V, Kaiser L, Weinschrott H, Schoser B, Deigner H-P, Meinke P, Kohl M. Meta-analysis towards FSHD reveals misregulation of neuromuscular junction, nuclear envelope, and spliceosome. Commun Biol. 2024, 7 ( 1): 640. doi: 10.1038/s42003-024-06325-z
  • Schindler K, Ruppel KE, Müller C, Köhl U, Fricke S, Schmiedel D. Linker-specific monoclonal antibodies present a simple and reliable detection method for scFv-based CARNK cells. Mol Ther Methods Clin Dev. 2024, 32 (3): 101328. doi: 10.1016/j.omtm.2024.101328. eCollection 2024 Sep 12.
  • Schmidt J R, Adamowicz K, Arend L, Lehmann J, List M, Poh P S P, Baumbach J, Kalkhof S, Laske T. Meta-analysis of proteomics data from osteoblasts, bone, and blood: Insights into druggable targets, active factors, and potential biomarkers for bone biomaterial design. J Tissue Eng. 2024, 15 :20417314241295332. doi: 10.1177/20417314241295332. eCollection 2024 Jan-Dec.
  • Schmidt M, Avagyan S, Reiche K, Binder H, Loeffler-Wirth HA. Spatial transcriptomics browser for discovering gene expression landscapes across microscopic tissue sections. Curr Issues Mol Biol. 2024, 46 (5): 4701-4720. doi: 10.3390/cimb46050284
  • Schrempel S, Kottwitz AK, Piechotta A, Gnoth K, Büschgens L, Hartlage-Rübsamen M, Morawski M, Schenk M, Kleinschmidt M, Serrano GE, Beach TG, Rostagno A, Ghiso J, Heneka MT, Walter J, Wirths O, Schilling S, Roßner S. Identification of isoAsp7-Aβ as a major Aβ variant in Alzheimer’s disease, dementia with Lewy bodies and vascular dementia. Acta Neuropathol. 2024, 148 (1): 78. doi: 10.1007/s00401-024-02824-9
  • Secondino S, Badoglio M, Rosti G, Labopin M, Delaye M, Bokemeyer C, Seidel C, Kanfer E, Metafuni E, Finke J, Bouhris JH, Kosmas C, Malard F, Pagani A, Kuball J, Köhl U, Ruggeri A, De Giorgi U, Pedrazzoli P. High-dose chemotherapy with autologous stem cell transplants in adult primary non-seminoma mediastinal germ-cell tumors. A report from the Cellular Therapy and Immunobiology working party of the EBMT. ESMO Open. 2024, 9 (9): 103692. doi: 10.1016/j.esmoop.2024.103692. Epub 2024 Sep 5.
  • Seliger B. Role of HLA-G in tumors and upon COVID-19 infection. Hum Immunol. 2024, 85 (3): 110792. doi: 10.1016/j.humimm.2024.110792. Epub 2024 Mar 29.
  • Stahl-Hennig C, Peter AS, Cordsmeier A, Stolte-Leeb N, Vestweber R, Socher E, Merida SA, Sauermann U, Bleyer M, Fraedrich K, Grunwald T, Winkler TH, Ensser A, Jäck H-M, Überla K. Genetic barrier to resistance: a critical parameter for efficacy of neutralizing monoclonal antibodies against SARS-CoV-2 in a nonhuman primate model. J Virol. 2024, 98 (7): e0062824. doi: 10.1128/jvi.00628-24. Epub 2024 Jun 20.
  • Subbarayan K, Al-Samadi A, Schäfer H, Massa C, Salo T, Biehl K, Vaxevanis C K, Ulagappan K, Wahbi W, Reimers M, Drexler F, Moreira-Soto A, Bachmann M, Seliger B. Altered ACE2 and interferon landscape in the COVID-19 microenvironment correlate with the anti-PD-1 response in solid tumors. Cell Mol Life Sci. 2024, 81 (1): 473. doi: 10.1007/s00018-024-05520-9
  • Sun C, Zhou D, He J, Liu H, Fu Y, Zhou Z, Leptihn S, Yu Y, Hua X, Xu Q. A panel of genotypically and pheno­typically diverse clinical Acinetobacter baumannii strains for novel antibiotic development. Microbiol Spectr. 2024 Aug 6;12(8):e0008624. doi: 10.1128/spectrum.00086-24. Epub 2024 Jun 25.
  • Tretbar S, Rurik JG, Rustad EH, Sürün D, Köhl U, Olweus J, Buchholz F, Ivics Z, Fricke S, Blache U. Non-viral vectors for chimeric antigen receptor immunotherapy. Nat Rev Methods Primers 4, 75 (2024). doi: 10.1038/s43586-024-00360-0
  • Vasilevska V, Guest PC, Szardenings M, Benros ME, Steiner J. Possible temporal relationship between SARS-CoV-2 infection and anti-NMDA receptor encephalitis: a meta-analysis. Transl Psychiatry. 2024, 14 (1): 139. doi: 10.1038/s41398-024-02831-0
  • Vaxevanis C, Bachmann M, Seliger B. Immune modulatory microRNAs in tumors, their clinical relevance in diagnosis and therapy. J Immunother Cancer. 2024, 12 (8): e009774. doi: 10.1136/jitc-2024-009774
  • Vera-Cruz S, Jornet Culubret M, Konetzki V, Alb M, Friedel S R, Hudecek M, Einsele H, Danhof S, Scheller L. Cellular therapies for multiple myeloma: engineering hope. Cancers (Basel). 2024, 16 (22): 3867. doi: 10.3390/cancers16223867
  • Vogt S, Scholl C, Grover P, Marks J, Dreischarf M, Braumann U-D, Strube P, Hölzl A, Böhle S. Novel AI-based algorithm for the automated measurement of cervical sagittal balance parameters. A validation study on pre- and postoperative radiographs of 129 patients. Global Spine J. 2024,  doi: 10.1177/21925682241227428. Online ahead of print.
  • Wagner JT, Müller-Schmucker SM, Wang W, Arnold P, Uhlig N, Issmail L, Eberlein V, Damm D, Roshanbinfar K, Ensser A, Oltmanns F, Peter AS, Temchura V, Schrödel S, Engel FB, Thirion C, Grunwald T, Wuhrer M, Grimm D, Überla K. Influence of AAV vector tropism on long-term expression and Fc-γ receptor binding of an antibody targeting SARS-CoV-2. Commun Biol. 2024, 7 (1): 865. doi: 10.1038/s42003-024-06529-3
  • Wang N, Zheng X, Leptihn S, Li Y, Cai H, Zhang P, Wu W, Yu Y, Hua X. Characteristics and phylogenetic distribution of megaplasmids and prediction of a putative chromid in Pseudomonas aeruginosa. Comput Struct Biotechnol J. 2024, 23: 1418-1428. doi: 10.1016/j.csbj.2024.04.002. eCollection 2024 Dec.
  • Wang Y, Lazaridou M-F, Kordaß T, Massa C, Vaxevanis CK, Eichmüller S, Seliger B. Unconventional microRNA role: enhancing the human leukocyte antigen class I antigen processing pathway via interacting with a silencer. Clin Transl Med. 2024, 14 (10): e70010. doi: 10.1002/ctm2.70010
  • White BS, de Reyniès A, Newman AM, Waterfall JJ, Lamb A, Petitprez F, Lin Y, Yu R, Guerrero-Gimenez ME, Domanskyi S, Monaco G, Chung V, Banerjee J, Derrick D, Valdeolivas A, Li H, Xiao X, Wang S, Zheng F, Yang W, Catania CA, Lang BJ, Bertus TJ, Piermarocchi C, Caruso FP, Ceccarelli M, Yu T, Guo X, Bletz J, Coller J, Maecker H, Duault C, Shokoohi V, Patel S, Liliental JE, Simon S; Tumor Deconvolution DREAM Challenge consortium; Saez-Rodriguez J, Heiser LM, Guinney J, Gentles AJ. Community assessment of methods to deconvolve cellular composition from bulk gene expression. Nat Commun. 2024, 15 (1): 7362. doi: 10.1038/s41467-024-50618-0
  • Yohannes M, Desalegn Z, Bauer M, Stückrath K, Anberbir E, Bekuretsion Y, Assefa M, Wakuma T, Worku Y, Santos P S C, Taylor L, Adissie A, Wickenhauser C, Massa C, Vetter M, Kantelhardt E J, Seliger B, Abebe T. Immune landscape of the tumour microenvironment in Ethiopian breast cancer patients. Breast Cancer Res. 2024, 26 (1):162. doi: 10.1186/s13058-024-01916-4
  • Yohannes M, Massad C, Desalegn Z, Stückrathe K, Mueller A, Anberber E, Bekuretsion Y, Assefai M, Santos P, Addissie A, Bauer M, Wickenhauser C, Taylor L, Vetter M, Kantelhardt E J, Abebe T, Seliger B. Blood immune profiling of Ethiopian patients with breast cancer highlights differentforms of immune escape. Oncoimmunology. 2024, 13 (1): 2436227. doi: 10.1080/2162402X.2024.2436227. Epub 2024 Dec 2.
  • Zolnowski D, Karp S, Warncke P, Zinn J, Pannach M, Herbst R, Hänel A, Morgner A, Ibach S, Fricke S, Hänel M. Challenges in the treatment of soft-tissue plasmacytoma: a retrospective analysis of 120 patients with extramedullary multiple myeloma. J Cancer Res Clin Oncol. 2024, 150 (10): 482. doi: 10.1007/s00432-024-05993-y
  • Zülke AE, Luppa M, Wirkner K, Reusche M, Sander C, Büchner R, Schomerus G, Then Bergh F, Lehmann J, Witte AV, Villringer A, Zeynalova S, Löffler M, Engel C, Riedel-Heller SG. Cognitive performance in adults with post COVID-syndrome: results from a German case-control study. J Psychiatr Res. 2024, 176: 377-383. doi: 10.1016/j.jpsychires.2024.06.036. Epub 2024 Jun 25.
  • Zwies C, Rodríguez AMV, Naumann M, Seifert F, Pietzsch M. Alternative strategies for the recombinant synthesis, DOPA modification and analysis of mussel foot proteins – a case study for Mefp-3 from Mytilus edulis. Protein Expr Purif. 2024, 219: 106483. doi: 10.1016/j.pep.2024.106483. Epub 2024 Apr 10.

Buchbeiträge

  • Adamatzky A, Huber F, Schnauß J. Chapter 13: Computing on actin bundles network. In: Adamatzky A (ed.): Actin computation. World Scientific, 2024, ISBN 978-981-12-8506-6, S. 245-261. doi: 10.1142/9789811285073_0013
  • Adamatzky A, Huber F, Schnauß J. Chapter 14: Actin droplet machine. In: Adamatzky A (ed.): Actin computation. World Scientific, 2024, ISBN 978-981-12-8506-6, S. 263-284-7. doi: 10.1142/9789811285073_0014
  • Adamatzky A, Schnauß J, Tuszynsik J. Chapter 1: Actin. In: Adamatzky A (ed.): Actin computation. World Scientific, 2024, ISBN 978-981-12-8506-6, S. 1-7. doi: 10.1142/9789811285073_0001
  • Blache U, Kebbel K, Quaiser A, Popp G, Franz P, Dünkel A, Thoma M, König N, Platzbecker U, Schmiedeknecht G, Fricke S, Köhl U. Technologien und Lösungsansätze für die effiziente Herstellung von Zelltherapeutika für die CAR-Immuntherapie. In: Fehse B et al.: Gen- und Zelltherapie 2.023 – Forschung, klinische Anwendung und Gesellschaft. Springer, 2024, Seite 123-137. doi: 10.1007/978-3-662-67908-1_8
  • Bondanza A, Köhl U, Hoffmann A, Toubert A. Biological Properties of cells other than HSCs. In: The EBMT handbook. Springer, 2024, Seite 67-71, doi: 10.1007/978-3-031-44080-9_8  

Sonstige Publikationen

Abstracts

  • Aerchlimann K, Heinrich D, Mattern K, Kuhlmeier D. Establishing a modular microfluidic organ-on-chip system for cells of acute myeloid leukemia. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Auw N von, Uhlig J, Bernert A-K, Serfling R, Kitte R, Hilger N, Schrader S, Seitz C, Blache U, Schmiedel D, Köhl U, Fricke S, Franz P, Dünkel A, Tretbar S. Ex vivo CAR-modification of NK cells via mRNA and GMP-compliant scale-up of feeder-free NK cell expansion. European Society of Gene & Cell Therapy (ESGCT), 22.-25.10.2024, Rom, Italien
  • Auw N von, Uhlig J, Bernert A-K, Serfling R, Kitte R, Hilger N, Schrader S, Seitz C, Dünkel A, Schmiedel D, Fricke S, Blache U, Köhl U, Tretbar S. Advancing cancer immunotherapy: lipid nanoparticle-mediated mRNA delivery for ex vivo engineering of anti-CD123 CAR-NK cells. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Blache U. ATMPs in cancer immunotherapy: demand, challenges and potential solutions. Elrig.de Forum - Von der Grundlagenforschung zur Produktion: Eine Reise durch die Methodenentwicklung zur ATMP-Entwicklung und Produktion, 7.3.2024, Darmstadt
  • Blaudszun A-R. Current status of Fraunhofer In Vivo Research Infrastructure. Korea-Germany Research Infrastructure Cooperation Workshop, 26.9.2024, Bonn
  • Blaudszun A-R. Immunonkologie: Immunsystem-gestützte Strategien zur Krebsbekämpfung. 30 Jahre Festveranstaltung, 13.-14.6.2024, Zittau
  • Blaudszun A-R. Preclinical development of Palintra® for the prevention of graft-versus-host disease (GvHD) - challenges of academic ATMP research. Arbeitsgemeinschaft für Angewandte Humanpharmakologie e.V. (AGAH) Annual Meeting, 17.-19.4.2024, Münster
  • Blaudszun A-R, Fricke S. Alternative cell sources for CAR-ATMPS. CAR T Cell Praxisfragen, 25.9.2024, Chemnitz
  • Bosward K, Logan B, Fertey J, Makert G, Mertens-Scholz K, Hollwedel F, Ganter M, Knittler M, Bauer B. Detection of Coxiella burnetii in dust samples from ruminant farms and new perspectives for a Q fever vaccine. International One Health Symposium, 17.-19.10.2024, Berlin
  • Bosward K, Logan B, House J,  Fertey J, Makert G, Mertens-Scholz K, Hollwedel F, Ganter M, Knittler M, Bauer B. Results of dust analysis for Coxiella burnetii on ruminant farms and a new approach for developing a Q fever vaccine. Tagung der DVG-Fachgruppe »Kleine Wiederkäuer und Neuweltkamele«, 11.-13.9.2024, Hannover
  • Bräuning S, Schiefer D, Möser C, Greiser S, Fricke S, Köhl U, Blache U, Tretbar S. MRNA technology for the development of Car T cells targeting fibrotic diseases. Eur J Rheumatol 2024, 11 (2), suppl 2, article OD088 / #740: S159. https://www.eurjrheumatol.org/en/14th-international-congress-on-autoimmunity-1619039
  • Burghardt BM, Kubat J, Schmidt JR, Wach J, Lehmann J, Güresir E, Schulz-Siegmund M, Kalkhof S. Method development for in-depth analysis of the human cranial proteome. Humboldt meets Leibniz – Emerging Topics in Biomedical Engineering and Implant Research, 24.9.2024, Hannover
  • Burghardt BM, Schmidt JR, Lehmann J, Kalkhof S. Evaluation of different depletion methods and development of an optimized LC-MS/MS method for murine deep plasma proteomics in preclinical safety assessment studies. HuPo World conference, 22.10.2024, Dresden
  • Çetin E, Freitag J, Arnold K, Auw N von, Warncke P, Janschel M, Bessler M, Tretbar S. Shifting gears in CAR T cell manufacturing: LNPs and AAVs as in vivo solutions. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Ciulean IS, Fischer J, Quaiser A, Bach C, Abken H, Tretbar US, Fricke S, Köhl U, Schmiedel D, Grunwald T. Harnessing anti-CD44v6 CAR-NK cells for effective head and neck squamous cell carcinoma treatment. J Immunother Cancer 2024, 12, abstract 250. doi: 10.1136/jitc-2024-SITC2024.0250
  • Ciulean IS, Fischer J, Quaiser A, Bach C, Abken H, Tretbar US, Fricke S, Köhl U, Schmiedel D, Grunwald T. Harnessing anti-CD44v6 CAR-NK cells for effective head and neck squamous cell carcinoma treatment. SITC 39th Annual Meeting (SITC 2024), 6.-10.11.2024, Houston, TX, USA
  • Costache F, Wang Z, Stoll A, Smith D, Reichelt H, Kölsch A, Lakshmireddy A, Lu Z. Silicon photonic biosensors for label-free detection of small biomolecules. 2024 Conference on Lasers and Electro-Optics Pacific Rim (CLEO-PR), 2024, Incheon, Republic of Korea, pp. 1-2, doi: 10.1109/CLEO-PR60912.2024.10676516
  • Eberlein V. AAV-mediated expression of therapeutic antibodies via minimal invasive application. Annual workshop of the GfV working group »Viral vectors for gene therapy and vaccination«, 18.-19.11.2024, Leipzig
  • Eberlein V, Rosencrantz S, Finkensieper J, Besecke J, Mansuroglu Y, Lange F, Schopf S, Dressman J, Thoma M, Hesse C, Fertey J, Ulbert S, Grunwald T. A formulated mucosal inactivated whole RSV vaccine protects mice in a challenge model. 33. Jahreskonferenz der Gesellschaft für Virologie e. V., 25.-28.3.2024, Wien, Österreich
  • Eberlein V, Rosencrantz S, Finkensieper J, Besecke J, Mansuroglu Y, Lange F, Schopf S, Dressman J, Thoma M, Hesse C, Fertey J, Ulbert S, Grunwald T. A formulated mucosal inactivated whole RSV vaccine protects mice in a challenge model. CIMD 5. Tag der Immunforschung, 12.3.2024, Frankfurt am Main
  • Eberlein V, Scheffel J, Frischbutter S., Obernolte H, Hesse C, Grunwald T. AAV-mediated expression of therapeutic antibodies via minimal invasive application. 11th European Seminar in Virology (EuSeV) »Viral Vectors - from Basic Research to Clinical Application«, 21.-23.10.2024, Bertinoro, Italien
  • Eberlein V, Scheffel J, Frischbutter S., Obernolte H, Hesse C, Grunwald T. AAV-mediated expression of therapeutic antibodies via minimal invasive application. Fraunhofer CIMD & TheraNova Winter School 2024, 9.-11.10.2024, Bad Nauheim
  • Fandrei D. Single cell multi-omic dissection of response and resistance to chimeric antigen receptor T cells against BCMA in relapsed multiple myeloma. 21st IMS Annual Meeting, 25.-28.9.2024, Rio De Janeiro, Brasilien
  • Fandrei D. The differences between Ide-cel and Cilta-cel in relapsed myeloma at single cell resolution. 66th ASH Annual Meeting and Exposition, 7.-10.12.2024, Orlando, FL, USA
  • Fandrei D, Rade M, Kreuz M, Fischer L, Born P, Seiffert S, Boldt A, Scolnick J, Venkatraman L, Xu S, Baber R, Wang S, Bach E, Hoffmann S, Metzeler K, Herling M, Jentzsch M, Herling C, Franke G-N, Köhl U, Platzbecker U, Vucinik V, Reiche K, Merz M. Cytotoxic CD4+ T cells are major drivers of side effects and response after chimeric antigen receptor T cells against BCMA. Clinical lymphoma, myeloma and leukemia. 2024, 24, suppl: 2S51-S326, P019. International Myeloma Society 21st Annual Meeting and Exposition, 25.-28.9.2024. doi:  10.1016/S2152-2650(24)01922-0
  • Fricke S. Biomarkers and prognostic factors vs. response to CAR-T cell therapy in r/r large B-cell lymphoma. MSGO Frühjahrstagung, 26.4.2024, Leipzig
  • Fricke S. Highlights/update ASH Congress San Diego (USA) – clinical studies with CAR-T cells. Fokus Hämatologie, 18.12.2024, online
  • Fricke S. Innovative cell and gene therapies in ophthalmology –  Can Saxocell® also support them? Annual conference Sächsische Augenärztliche Gesellschaft, 30.11.2024, TU Chemnitz
  • Fricke S. Medizinischer Fortschritt durch klinische Forschung. Patientenkongress OCC, 1.6.2024, Chemnitz 
  • Fricke S. Optimization of novel immune cell therapies for hematological neoplasms - challenges and opportunities. 9. Saaleforum 2024, Christliche Akademie für Pflegeberufe, 14.8.2024, Halle (Saale)
  • Fricke S. Patient allocation and management of toxicities in CAR-T cell therapies. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Fricke S. Secondary immunodeficiencies - what is important? Are there prophylactic options? Ways to avoid of toxicities of antineoplastic therapies. Paracelsusklinik Schöneck, 11.9.2024, Schöneck
  • Fricke S. Update on immunotherapies for hematological malignancies. Fokus Hämatologie, 5.6.2024, online
  • Fricke S. Update on immunotherapies for hematological malignancies. Jubiläumsveranstaltung »15 Jahre Onkolotse«, Sächsische Krebsgesellschaft, 15.11.2024, online
  • Gänzle M, Pirlich M, Dietz A, Bloße A, Arnold K, Möser C, Smith D, Neumuth T. NANOVISION: Development of HNSCC-specific markers for visualization and surgical removal in head and neck oncology. Laryngo-Rhino-Otologie 2024; 103 (S02): 225 - 225. doi: 10.1055/s-0044-1784737
  • Gebhardt C, Auw N von, Hilger N, Kitte R, Serfling R, Franz P, Fricke S, Köhl U, Tretbar S. CARcoon – Scaling up mRNA CAR-T cell manufacturing onto the Cocoon® platform. 17th Leipzig Research Festival, 18.1.2024, Leipzig
  • Gebhardt C, Auw N von, Kitte R, Serfling R, Rabel M, Komnig D, Gata G, Fricke S, Coin I, Tretbar S. Optimizing and scaling up mRNA-based CAR-T cell generation using lipid nanoparticles. 1st Fraunhofer CIMD Symposium on RNA-Based Therapeutics, 30.9.2024, Hannover
  • Gebhardt C, Auw N von, Kitte R, Serfling R, Rabel M, Komnig D, Gata G, Fricke S, Coin I, Tretbar S. Optimizing and scaling up mRNA-based CAR-T cell generation using lipid nanoparticles. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Gerloff D, Cynis H, Gul S, Uebel A, Kewitz-Hempel S, Hiemer S, Sunderkötter C. Inhibition of epigenetic regulators EZH2 or HDACs improves the response of melanoma cells resistant to targeted therapies. Deutscher Hautkrebskongress, 25.-28.9.2024, Würzburg
  • Große F. Spatial transcriptomics of melanoma tissues reveals new tumor-immune cell interactions. 23rd European Conference on Computational Biology, 16.-20.9.2024, Logomo, Turku, Finnland
  • Haag S, Volland S, Müller C, Kratz H, Dossin A, Kersting M, Dähne M, Bernemann I, Richter V, Behrens F, Hohlfeld J, Krug N, Lehmann J, Köhm M, Dauth S, Illig T, Müller M. CIMD Biobank – an operative central biobank infrastructure at the Fraunhofer Cluster of Excellence Immune-mediated diseases. Fraunhofer CIMD - RNA-Symposium, 30.9.2024, Hannover
  • Haupt J, Keminer O, Fey C, Windshügel B, Wiltzsch V, Schmidt J R, Ivaskevica K, Schädlich J, Biermann M, Vollack-Hesse N, Schiefke I, Zdzieblo D, Metzger M, Köhl U, Geißlinger G, Claussen C, Buchholz M, Kalkhof S, Lehmann J. Identification and in vitro validation of new AHR ligands as potential therapeutics for inflammatory bowel diseases. AHR'24 - 6th International AHR Meeting: Research, Prevention, Therapy, 12.-15.6.2024, Düsseldorf
  • Haupt J, Keminer O, Fey C, Windshügel B, Wiltzsch V, Schmidt J R, Ivaskevica K, Schädlich J, Biermann M, Vollack-Hesse N, Schiefke I, Zdzieblo D, Metzger M, Köhl U, Geißlinger G, Claussen C, Buchholz M, Kalkhof S, Lehmann J. Identification and in vitro validation of new AHR ligands as potential therapeutics for inflammatory bowel diseases. Fraunhofer CIMD - Day of Immune Research, 12.3.2024, Frankfurt/Main
  • Heitor Lopes A. Integration of chemiluminescence-based SPARCL assay on microfluidic platform with SPAD-based CMOS line sensor IC for rapid cytokine detection. POCT Meeting Leipzig, 17.-18.4.2024, Leipzig  
  • Herrmann A, Hahn F, Wangen C, Wagner S, Häge S, Cordsmeier A, Weil T, Huszinger V, Groß R, Heinen N, Reuter S, Uhlig N, Eberlein V, Issmail L, Schreieck A, Peelen E, Pfänder S, Grunwald T, Münch J, Sparrer K, Ensser A, Marschall M, Mühler A, Vitt D, Kohlhof H. Preclinical development of host-directed dual-target small molecule inhibitors as broad-spectrum antivirals. 33. Jahreskonferenz der Gesellschaft für Virologie e. V., 25.-28.3.2024, Wien, Österreich
  • Issmail L, Ramsbeck D, Jäger C, Henning T, Kleinschmidt M, Buchholz M, Grunwald T. Novel small-molecule inhibitors targeting the entry of the respiratory syncytial virus. 33. Jahreskonferenz der Gesellschaft für Virologie e. V., 25.-28.3.2024, Wien, Österreich
  • Ivics Z, Miskey C, Botezatu L, Sandoval-Villegas N, Ochmann M, Guenechea Amurrio G, Bueren J, Bexte T, Ullrich E. The Sleeping Beauty transposon system: A molecular parasite tamed for genome engineering. Annual Conference of the European Socity of Animal Cell Technologies, 24.-27.6.2024, Edinburgh, Vereinigtes Königreich
  • Ivics Z, Miskey C, Botezatu L, Sandoval-Villegas N, Ochmann M, Guenechea Amurrio G, Bueren J, Bexte T, Ullrich E. Advances in non-viral engineering of therapeutic cells with the Sleeping Beauty transposon system. Annual Meeting of the Hungarian Biochemical Society, 29.-31.8.2024, Budapest, Ungarn
  • Kalkhof S. Guiding biomaterial design through the power of omics technologies. Innovation in Chemical Sciences, 20.11.2024, Zagreb, Kroatien
  • Kebbel K. Qualification and validation – a versatile and efficient quality tool in the ATMP manufacturing: case study for a clinical phase I/II CAR-T cell product. ECA Live Online Training »Advanced GMP for ATMPs«, 2.-3.7.2024, online
  • Kitte R, Rabel M, Fricke S, Köhl U, Tretbar S. Optimized mRNA design and delivery for non-viral generation of chimeric antigen receptor (CAR) T cells. 17th Research Festival for Life Sciences, 18.1.2024, Leipzig
  • Kleinschmidt M, Rahfeld JU, Gnoth K, Piechotta A, Kottwitz AK, Koska I, Künemund A. Generation of monoclonal antibodies: accompanying analytics by SPR and ELSIA. Cytiva User Day, 28.8.2024, Leipzig
  • Kleinschmidt M, Schenk M, Rahfeld JU, Schilling S, Hoffmann T, Hettmann T, Lues I. Anti-amyloid beta antibodies as potential drugs for treatment of alzheimer's Disease / Characterization of binduing properties by SPR. Biacore User Meeting, 27.11.2024, Berlin
  • Klier J. AI driven design of CAR T-cell therapies and targeting. LIT Symposium, 26.-27.6.2024, Regensburg
  • Klier J. AI driven design of CAR T-cell therapies and targeting. SECAI on-site Meeting, 29.-30.8.2024, Dresden
  • Klier J. AI driven design of CAR T-cell therapies and targeting. SECAI-Spring Meeting 2024, 18.-21.3.2024, Grimma
  • Klier J. Exploring the de novo- likeness of natural proteins. European Rosettacon, 11.-13.11.2024, Kopenhagen, Dänemark
  •  
  • Köhl U. CAR effector cells: pushing the boundaries in cancer treatment and beyond. 1st ATMP@Charité Symposium, 19.11.2024, Berlin
  • Köhl U. CAR effector cells: pushing the boundaries in cancer treatment and beyond. ATMP Symposium des PEI, 28.11.2024, Potsdam
  • Köhl U. CAR effector cells: pushing the boundaries in cancer treatment and beyond. Translational Research Rounds der Medizinischen Hochschule Brandenburg (MHB), 8.7.2024, Brandenburg/Havel
  • Köhl U. Centralized and decentralized academic manufacturing of CAR effector cells as living drugs. ACHEMA 2024, 10.-14.6.2024, Frankfurt am Main
  • Köhl U. Development and manufacturing of CAR T and CAR NK cells: pushing the boundaries in cancer treatment and beyond. 9th German Pharm-Tox Summit 2024, 13.-14.3.2024, München
  • Köhl U. Familie und Karriere, wie schafft man den Spagat? SFOM-Symposium »Shaping the Future of Medicine«, 24.-25.9.2024, Leipzig
  • Köhl U. Fortschritte bei zellulären Immuntherapien: Von »lebenden Krebsmedikamenten« bis zur Behandlung von Volkskrankheiten. Öffentliche Frühjahrssitzung der Sächsischen Akademie der Wissenschaften, 12.4.2024, Leipzig
  • Köhl U. From CAR effector cell manufacturing to vaccines using mRNA technology? 40. API Jahrestagung (Arbeitsgemeinschaft Pädiatrische Immunologie ), 2.-3.5.2024, Oberursel
  • Köhl U. Gene-modified CAR effector cells: pushing the boundaries in cancer treatment and beyond. Workshop »Viral Vectors for Gene Therapy and Vaccination« der GfV, 18.11.2024, Leipzig
  • Köhl U. Health technology at Fraunhofer with a special view to living drugs. 40. Chemnitzer Seminar Health Systems, 3.-4.12.2024, Chemnitz
  • Köhl U. Manufacturing of CAR effector cells: pushing the boundaries in cancer treatment and beyond. CREATIC Platin Conference, 3.-4.11.2024, Brno, Tschechien
  • Köhl U. Qualitätskontrolle für Herstellung und Patientenmonitoring bei CAR-T-Zelltherapie. IGLD-Jahrestagung, 7.-8.3.2024, Leipzig
  • Köhl U. Scalable manufacturing of CAR T cells for cancer immunotherapy. 50. Annual Meeting of EBMT, 14.-17.4.2024, Glasgow, Vereinigtes Königreich
  • Köhl U. Trends in der präklinischen Entwicklung, Testung und Herstellung von Gen- und Zelltherapien. Zukunftsforum »Zeitenwende in der Biotechnologie«, 21.11.2024, Berlin
  • Köhl U. Viral and non-viral gene transfer for manufacturing of CAR effector cells. Netzwerkveranstaltung »Virus based therapeutics«, 29.11.2024, Ulm
  • Köhl U. Von frühen zu späten klinischen ZGT-Studien: dezentrale und zentrale Herstellung. Netzwerkveranstaltung »Translationale Forschung in der Personalisierten Medizin – Chancen und Hürden«, 6.-7.2.2024, Berlin
  • Kölsch A, Sandetskaya N, Mattern K. CampyTube–a seamless integration of a molecular test and lateral flow detection. Advanced Lateral Flow Conference, 13.2.2024, San Diego, CA, USA
  • Körtge A, Klaus T, Scheier J, Wasserkort R. Abstracts from EuroELSO 2024 - 24th-27th April - Krakow, Poland - in-vitro analysis of drug and catecholamine adsorption by the CytoSorb® device. Perfusion2024, 39 (1), abstract 263, suppl. special issue EuroELSO, 24th-27th April Krakow. doi: 10.1177/02676591241239138
  • Kreuz M. A transcriptome based prognostic signature for formalin-fixed paraffin-embedded biopsies of prostate cancer. Mittelerde Meeting, 29.2.-1.3.2024, Jena 
  • Kreuz M. In-depth molecular characterization of patients undergoing CAR-T cell therapy reveals novel biomarkers for response and severe adverse events. Workshop on Computational Models in Biology and Medicine 2024, 6.-7.6.2024, Dresden 
  • Kuhlmeier D. Diagnostik neu gedacht – mit Blut, Atemluft & Co zur individualisierten Therapie. 8. Life Sciences Forum Sachsen: Präzisionsmedizin - von Diagnostik bis Therapie, 26.11.2024, Leipzig
  • Kuhlmeier D. Fertigungslösungen für Medizinprodukte in Chemnitz. 3. DIANA Workstation, IMK Health, 10.9.2024, Chemnitz 
  • Kuhlmeier D. Fraunhofer Spinoff: INTU diagnostics. Finance Days, BIO CITY Leipzig, 24.10.2024, Leipzig
  • Kuhlmeier D. Revolutionizing targeted therapies: innovative diagnostics and biomarker detection for precision medicine. Fraunhofer Symposium Sendai, 9.12.2024, Sendai, Japan, online 
  • Kuhlmeier D. Von der Idee zur Umsetzung - Fertigungstechnologien für die Point-of-Care-Diagnostik. 2. DIANA Workstation, Firma SITEC, 6.3.2024, Chemnitz  
  • Kuhn C. CERTAINTY: Using single-cell multi-omics to fevelop a virtual twin (VT) for personalized cancer immunotherapy. Current Topics in Bioinformatics 2024 | Advances in single cell- and spatially resolved technologies, Max Delbrück Center, 17.6.2024, Berlin
  • Kuhn C. Fraunhofer IZI (RIBOLUTION Biomarker Center). Meet the Dutch! German-Dutch networking event on Regenerative Medicine; Embassy of the Kingdom of the Netherlands, 14.5.2024, Berlin
  • Ladeira L, Mazein A, Ostaszewski M, Verhoeven A, Kuchovská E, Sanz-Serrano J, Drees A, Reiche K, Sewald K, Fritsche E, Vinken M, Geris L, Staumont B. Using a systems biology approach to construct adverse outcome pathway networks aligned with the FAIR principles. Toxicol letters. 2024, 399, suppl. 2: S58, short orals sessions, OS02. doi: 10.1016/j.toxlet.2024.07.164
  • Linnert M, Gabriel F, Wermann M, Schlenzig D, Schuster C, Radics U, Hucke A, Schilling S. Structural investigation of bacterial Urease using X-ray structure analysis - basis for the developemnt of new Urease inhibitors. 32. Jahrestagung der Deutschen Gesellschaft für Kristallographie, 18.-21.3.2024, Bayreuth
  • Löffler D, Sirini C, Scholz A, Große F, Blumert C, Reiche K, Casucci M. Spatial transcriptomics of the tumor microenvironment of solid tumors treated with CAR-T cells in HPSC-humanized animals. EBMT - EHA 6th European CAR T-cell Meeting, 15.-17.2.2024, Valencia, Spanien
  • Luu M, Sanges C, Dreuillet C, Pennings E, Casucci M, Franz P et al. T2EVOLVE: Standardization of pre-clinical and clinical development of engineered T cell therapy in Europe; a cross-functional multi-stakeholder initiative. Cytotherapy, special issue: Abstracts of the 30th Annual ISCT Meeting May 29-June 1, 2024, Volume 26, Issue 6, Supplement, June 2024, Pages S117-S118. doi: 10.1016/j.jcyt.2024.03.223
  • Oberbach A, Lehmann S, Schlichting N, Vollkwein M. Optimierung der Interoperabiltät in Patientenpfaden: eine Herausforderung für visionäre Klinikstrukturen. BMC Jahrestagung 2024, 30.1.2024, Berlin
  • Pecic K, Müller C, Seklic D, Avdovic E, Schmidt JR, Jovanovic M, Markovic Z, Lehmann J, Kalkhof S. Pd(II) coumarin complexes as potential agents against breast carcinoma. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Quadir Afiridi S, Donner A-K, Subbotina A, Uhlig N, Grunwald T, Ulbert S, Fertey J. A simple system to test the capacity of filter materials to retain respiratory viruse. 33. Jahreskonferenz der Gesellschaft für Virologie e. V., 25.-28.3.2024, Wien, Österreich
  • Rade M. Development of a time series single-cell transcriptomic CAR T-cell atlas to explore the dynamics of CAR T-cell therapy. EBMT-EHA 6th European CAR T-cell Meeting, 15.-17.02.2024, Valencia, Spanien
  • Rade M. Single-cell multiomic dissection of toxicity and response to BCMA-directed CAR T cells. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig 
  • Reiche K. Advancing the development and production of ATMPs through the use of advanced molecular diagnostic tools. Jahrestagung IGLD (Interdisziplinäre Gruppe für Labormedizin), 7.-9.3.2024, Leipzig
  • Reiche K. CERTAINTY: Cellular immontherapy virtual twin for personalised cancer treatment. 6th CAR T Cell meeting, 15.-17.2.2024, Valencia, Spanien
  • Reiche K. CERTAINTY: Cellular immontherapy virtual twin for personalised cancer treatment. EBMT Annual Meeting, 14.-17.4.2024, Glasgow, Vereinigtes Königreich 
  • Reiche K. CERTAINTY: Cellular immontherapy virtual twin for personalised cancer treatment. EDITH Technical Meeting, 16.4.2024, online
  • Renner A, Fricke S, Koehl U, Schmiedel D. Enhancing CAR-T and CAR-NK cell therapy for solid tumors by targeting a proteolytically cleaved 8-amino acid peptide epitope. 31st Annual Congress of the European Society of Gene and Cell Therapy (ESGCT) 2024, Rome, Italy
  • Roth K, Loeffler D, Blumert C, Scholz A, Reiche K, Schiefer D, Hilger N, Tretbar S, Köhl U, Fricke S, Blache U. Ex vivo Modification of hematopoietic cell transplants in GvHD prevention: single treatment with the anti-human CD4 antibody MAX.16H5 can outperform state-of-the-art immunosuppressants. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Salti H et al. Decellularization of whole rat kidneys: application of physical and chemical methods. TERMIS World Congress (Tissue Engineering and Regenerative Medicine International Society), 25.-28.6.2024, Seattle, WA, USA
  • Salti H et al. Establishment of a human 3D kidney tissue model using decellularized rat kidney slices. TERMIS World Congress (Tissue Engineering and Regenerative Medicine International Society) 25.-28.6.2024, Seattle, WA, USA
  • Schenk M, Rahfeld J-U, Parthier C, Stubbs M T, Linnert M. Targeting Parkinson’s: structural and therapeutic perspectives on the interaction of antibody 5G4 with α-synuclein. 26th Heart of Europe Bio-Crystallography Meeting (HEC24), 26.-28.9.2024, Krakau, Polen
  • Schmidt JR, Adamowicz K, Arend L, Lehmann J, List M, Poh PSP, Baumbach J, Kalkhof S, Laske T. Systematic proteomic meta-analysis of osteoblasts, bone, and blood: identifying druggable targets, active factors, and biomarkers for bone biomaterial development. HuPo World conference, 23.10.2024, Dresden
  • Schmidt JR, Adamowicz K, Arend L, Lehmann J, List M, Poh PSP, Baumbach J, Kalkhof S, Laske T. Comprehensive Proteomic Meta Analysis of Osteoblasts, Bone, and Blood: Discovering Druggable Targets, Key Factors, and Biomarkers for Bone Biomaterial Innovation. e:Med meeting in Systems Medicine, 21.11.2024, Hamburg
  • Schmidt JR, Haupt J, Riemschneider S, Kämpf C, Löffler D, Blumert C, Reiche K, Köhl U, Kalkhof S, Lehmann J. Comparison of transcriptomic signatures in murine macrophages induced by toxic (benzo[a]pyrene) and non-toxic (indol-3-carbinol) AHR ligands. AHR'24 - 6th International AHR Meeting: Research, Prevention, Therapy, 12.-15.6.2024, Düsseldorf
  • Schmidt JR, Puizina J, Stagljar I, Markovic Z, Kalkhof S. BayHost stimulated research and teaching cooperations of Coburg with Croatia and Serbia in proteomics and oncology. BayHost conference, 27.-28.6.2024, Regensburg
  • Schmidt JR, Wiltzsch V, Adamowicz K, Arend L, Lio CT, Dias DB, Lehmann J, Lingner T, Tsoy O, Poh PSP, Laske T, Baumbach J, Kalkhof S. Linking local and systemic dysregulations in compromised bone healing under diabetic conditions by proteomics analyses. Annual Meeting of the ASMS, 5.6.2024, Anaheim, CA, USA
  • Schmidt JR, Wiltzsch V, Burghardt BM, Kalkhof S. Optimizing proteomics sample preparation and measurement for preclinical safety and efficacy studies. Post ASMS Go Local Symposium, 25.6.2024, Halle (Saale)
  • Schwarzer A, Ziegler U, Fertey J, Vahlenkamp TW, Groschup MH, Ulbert S. Differentiation of zoonotic flaviviruses in birds and horses using mutated recombinant envelope proteins in serological assays. International One Health Symposium, 17.-19.10.2024, Berlin
  • Serfling R, Degenhardt A, Fricke S, Köhl U, Tretbar S. Accelerating innovation in chimeric antigen receptors: harnessing mRNA for rapid screening with CARFinder. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Serfling R, Degenhardt A, Fricke S, Köhl U, Tretbar S. Accelerating innovation in chimeric antigen receptors: harnessing mRNA for rapid screening. ESGCT Congress, 22.-25.10.2024, Rom, Italien
  • Serfling R, Kitte R, von Auw N, Bräuning S, Fricke S, Köhl U, Tretbar S. Accelerating mRNA therapeutics in cancer immunotherapy: designing efficient CAR-T cell constructs. RNA-Based Therapeutics Fraunhofer CIMD Symposium, 30.9.2024, Hannover  
  • Smith D. Functional precision analysis of biological materials at Fraunhofer-Zentrum Erfurt (FZE). IMMUNE-ACT, 22.8.2024, Jena
  • Smith D. Interrogating and blocking multimeric virus surface proteins with DNA-templated oligovalence. 6th Functional DNA Nanotechnology Workshop, 28.6.2024, München
  • Smith D. Universalizing DNA nanotechnology to diagnostic platforms with NuTELA. DNA Mitteldeutschland Workshop, 23.5.2024, Jena
  • Smith D, Schönfelder J. Precision analysis of biological materials at the Fraunhofer Centre in Erfurt. TU Ilmenau, 7.8.2024, Ilmenau
  • Tretbar S. CAR Finder Technologie. AHEAD Pitch Night, September 2024, Leipzig
  • Tretbar S. mRNA-LNP technology for safe CAR cell therapy. Gesundheitscampus für Immunologie, Infektiologie und Inflammation (GC-I³) Seminar, 8.8.2024, Magdeburg
  • Tretbar S. RNAuto - automated production of mRNA therapeutics. GENAP Summit, 22.2.2024, Genf, Schweiz
  • Tretbar S. RNAuto - automated production technologies of mRNA-based vaccines and cell therapies. CIMD RNA Symposium, 30.9.2024, Hannover
  • Uhlig J, von Auw N, Tretbar S, Blache U, Schmiedel D, Köhl U, Fricke S, Franz P, Dünkel A. GMP-compliant up-scaling of an optimized feeder-free NK cell expansion protocol. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Ulbert S. Generation of inactivated vaccines by low-energy electron irradiatio. Workshop on the development of irradiated vaccines, 16.-20.9.2024, Tunesien
  • Ulbert S. Irradiation research at Fraunhofer IZI. IAEA Research Coordination Meeting, 12.6.2024, Wien, Österreich
  • Ulbert S. Reducing flavivirus vaccine-induced immunological cross-reactivity. World Vaccine Congress, 30.10.2024, Barcelona, Spanien
  • Wagner JT, Müller-Schmucker SM, Wang W, Arnold P, Uhlig N, Issmail L, Eberlein V, Damm D, Roshanbinfar K, Ensser A, Oltmanns F, Peter AS, Temchura V, Schrödel S, Salomon M, Engel FB, Thirion C, Grunwald T, Wuhrer M, Grimm D, Überla K. Long-lasting antibody delivery by a myotropic Adeno-Associated Virus (AAV) capsid variant: high serum levels, favourable glycosylation profile and protection from SARS-CoV-2 challenge. DG-GT-Jahrestagung, 6.-8.3.2024, München
  • Warncke P, von Auw N, Kitte R, Rabel M, Hänel M, Fricke S, Köhl U, Tretbar S. Optimization and upscaling of lipid nanoparticle (LNP) mediated mRNA delivery for transient CAR T and CAR NK cell generation. Deutsche Pharmazeutische Gesellschaft e.V. (DPHG), 23.9.2024, Münster
  • Weich A, Güse E, Bruns H, Böttcher M, Mougiakakos D, Tretbar S, Schmiedel D, Kitte R, Vera J, Lischer C. Identification and classification of CAR vector insertion sites using long-read DNA sequencing. Leipzig Immune Oncology (LION) Conference, 12.-13.11.2024, Leipzig
  • Weirauch U. Plenary Session IV: Focus on central Europe: Tackling the Lowlands of data on living therapies. BEACON: Mobilisong Collaboration among Stakeholders to Optimise the Growing Potential of Data for Tackling Cancer, Stakeholder COnference, 16.-17.5.2024, Warschau, Polen
  • Weiß R, Hoffmann D S, Schoeder C T, Fertey J, Ulbert S. Flavivirus vaccine strategies. International One Health Symposium, 17.-19.10.2024, Berlin
  • Weiß R, Issmail L, Rockstroh A, Grunwald T, Fertey J, Ulbert S. Research on vaccine strategies against flaviviruses. 33. Jahreskonferenz der Gesellschaft für Virologie e. V., 25.-28.3.2024, Wien, Österreich
  • Wenzel E. Innovations in home care testing: from infectious to chronic disease monitoring. POCT Meeting Leipzig, 17.-18.4.2024, Leipzig
  • Wiltzsch V, Dias D B, Schmidt JR, Adamowicz K, Chan L W, Laske T, Baumbach J, Lehmann J, Kirwan JA, Poh P S P, Kalkhof S. Multi-omics profiling of bone regeneration in diabetes reveals association of increased mast cell activity with healing impairment. HuPo World conference, 22.10.2024, Dresden
  • Wiltzsch V, Dias DB, Schmidt JR, Adamowicz K, Chan LW, Laske T, Baumbach J, Lehmann J, Kirwan JA, Poh PSP, Kalkhof S. Advancing personalized scaffolds through proteomic profiling of diabetic bone regeneration. Humboldt meets Leibniz – Emerging Topics in Biomedical Engineering and Implant Research, 24.9.2024, Hannover
  • Wiltzsch V, Dias DB, Schmidt JR, Adamowicz K, Chan LW, Laske T, Baumbach J, Lehmann J, Kirwan JA, Poh PSP, Kalkhof S. Multi-omics profiling of bone regeneration in diabetes links increased mast cell activity with healing impairment. e:Med meeting in Systems Medicine, 22.11.2024, Hamburg
  • Wiltzsch V, Schmidt J R, Wang L W, Lauterbach T, Dias D B, Lehmann J, Poh P S P, Kalkhof S. Advancing bone proteomics: a novel extraction method applied to diabetic bone healing models. Annual Meeting of the DGMS, 12.3.2024, Freising