Fraunhofer-Institut für Zelltherapie und Immunologie IZI
Fraunhofer-Institut für Zelltherapie und Immunologie IZI

Next-Generation Diagnostics

Publikationen

  • Rade M, Kreuz M, Borkowetz A, Sommer U, Blumert C, Füssel S, Bertram C, Löffler D, Otto DJ, Wöller LA, Schimmelpfennig C, Köhl U, Gottschling AC, Hönscheid P, Baretton GB, Wirth M, Thomas C, Horn F, Reiche K. A reliable transcriptomic risk-score applicable to formalin-fixed paraffin-embedded biopsies improves outcome prediction in localized prostate cancer. Mol Med. 2024 Feb 1;30(1):19. doi: 10.1186/s10020-024-00789-9
  • Anders I M, Schimmelpfennig C, Wiedemann K, Löffler D, Kämpf C, Blumert C, Reiche K, Kunz M, Anderegg U, Simon J-C, Ziemer M. Atypical fibroxanthoma and pleomorphic dermal sarcoma – gene expression analysis compared with undifferentiated cutaneous squamous cell carcinoma. J Dtsch Dermatol Ges 2023, 21 (5): 482-491. doi: 10.1111/ddg.15006
  • Rade M, Böhlen S, Neuhaus V, Löffler D, Blumert C, Merz M, Köhl U, Dehmel S, Sewald K, Reiche K. A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation. Genome Biol. 2023, 24(1): 287. doi: 10.1186/s13059-023-03120-7
  • Schimmelpfennig C, Rade M, Füssel S, Löffler D, Blumert C, Bertram C, Borkowetz A, Otto D J, Puppel S-H, Hönscheid P, Sommer U, Baretton G B, Köhl U, Wirth M, Thomas C, Horn F, Kreuz M, Reiche K. Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer. BMC Cancer 2023, 23, article 575. doi: 10.1186/s12885-023-11019-6
  • Schmidt J R, Haupt J, Riemschneider S, Kämpf C, Löffler D, Blumert C, Reiche K, Koehl U, Kalkhof S, Lehmann J. Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages. Front Immunol 2023, 14: article number 1156493. doi: 10.3389/fimmu.2023.1156493
  • Haehnel S, Rade M, Kaiser N, Reiche K, Horn A, Loeffler D, Blumert C, Rapp F, Horn F, Meixensberger J, Renner C, Mueller W, Gaunitz F, Bechmann I, Winter K. RNA sequencing of glioblastoma tissue slice cultures reveals the effects of treatment at the transcriptional level. FEBS Open Bio. 2022 Feb;12(2):480-493. doi: 10.1002/2211-5463.13353. Epub 2021 Dec 29 
  • Walcher L, Kistenmacher AK, Sommer C, Böhlen S, Ziemann C, Dehmel S, Braun A, Tretbar US, Klöß S, Schambach A, Morgan M, Löffler D, Kämpf C, Blumert C, Reiche C, Beckmann J, König U, Standfest B, Thoma M, Makert GR, Ulbert S, Kossatz-Böhlert U, Köhl U, Dünkel A, Fricke S. Low Energy Electron Irradiation Is a Potent Alternative to Gamma Irradiation for the Inactivation of (CAR-)NK-92 Cells in ATMP Manufacturing. Front Immunol. 2021 Jun 4:12:684052. doi: 10.3389/fimmu.2021.684052. eCollection 2021.
  • Kreuz M, Otto DJ, Fuessel S, Blumert C, Bertram C, Bartsch S, Loeffler D, Puppel SH, Rade M, Buschmann T, Christ S, Erdmann K, Friedrich M, Froehner M, Muders MH, Schreiber S, Specht M, Toma MI, Benigni F, Freschi M, Gandaglia G, Briganti A, Baretton GB, Loeffler M, Hackermüller J, Reiche K, Wirth M, Horn F. ProstaTrend-A Multivariable Prognostic RNA Expression Score for Aggressive Prostate Cancer. European Urology 78 (2020), 3, Seite 452-459. dx.doi.org/10.1016/j.eururo.2020.06.001
  • Haehnel S, Reiche K, Loeffler D, Horn A, Blumert C, Puppel SH, Kaiser N, Rapp F, Rade M, Horn F, Meixensberger J, Bechmann I, Gaunitz F, Winter K. Deep sequencing and automated histochemistry of human tissue slice cultures improve their usability as preclinical model for cancer research. Sci Rep. 2019 Dec 27;9(1):19961
  • Oberbach A, Schlichting N, Feder S, Lehmann S, Kullnick Y, Buschmann T, Blumert C, Horn F, Neuhaus J, Neujahr R, Bagaev E, Hagl C, Pichlmaier M, Rodloff AC, Gräber S, Kirsch K, Sandri M, Kumbhari V, Behzadi A, Behzadi A, Correia JC, Mohr FW, Friedrich M. New insights into valve-related intramural and intracellular bacterial diversity in infective endocarditis. PLoS one. 12 (2017), 4, Art. e0175569, 20 S. dx.doi.org/10.1371/journal.pone.0175569
  • Kalkhof S, Schildbach S, Blumert C, Horn F, von Bergen M, Labudde D.  PIPINO: A software package to facilitate the identification of protein-protein inter­actions from affinity purification mass spectrometry data. BioMed research international. (2016), Art. 2891918, 13 S. dx.doi.org/10.1155/2016/2891918
  • Hackermüller J, Reiche K, Otto C, Hösler N, Blumert C, Brocke-Heidrich K, Böhlig L, Nitsche A, Kasack K, Ahnert P, Krupp W, Engeland K, Stadler PF, Horn F. Cell cycle, oncogenic and tumor suppressor pathways regulate numerous long and macro non-protein-coding RNAs. Genome Biology. 2014 Mar 4;15(3):R48. DOI http://dx.doi.org/10.1186/gb-2014-15-3-r48
  • Blumert C, Kalkhof S, Brocke-Heidrich K, Kohajda T, von Bergen M, Horn F. Analysis of the STAT3 interactome using in-situ biotinylation and SILAC. J Proteomics. 2013 Dec 6;94:370-86. DOI dx.doi.org/10.1016/j.jprot.2013.08.021
  • Bauer K, Kretzschmar AK, Cvijic H, Blumert C, Löffler D, Brocke-Heidrich K, Schiene-Fischer C, Fischer G, Sinz A, Clevenger CV, Horn F. Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells. Oncogene. 2009 Aug 6;28(31):2784-95. DOI dx.doi.org/10.1038/onc.2009.142
  • Cvijic H, Bauer K, Löffler D, Pfeifer G, Blumert C, Kretzschmar AK, Henze C, Brocke-Heidrich K, Horn F. Co-activator SRC-1 is dispensable for transcriptional control by STAT3. Biochem J. 2009 Apr 28;420(1):123-32. DOI dx.doi.org/10.1042/BJ20081989
  • Löffler D, Brocke-Heidrich K, Pfeifer G, Stocsits C, Hackermüller J, Kretzschmar AK, Burger R, Gramatzki M, Blumert C, Bauer K, Cvijic H, Ullmann AK, Stadler PF, Horn F. Interleukin-6 dependent survival of multiple myeloma cells involves the Stat3-mediated induction of microRNA-21 through a highly conserved enhancer. Blood. 2007 Aug 15;110(4):1330-3.