Fraunhofer-Institut für Zelltherapie und Immunologie IZIAntimikrobielle Biotechnologie
- Arumugam S N, Manohar P, Sukumaran S, Sadagopan S, Loh B, Leptihn S, Nachimuthu R. Antibacterial efficacy of lytic phages against multidrug-resistant Pseudomonas aeruginosa infections in bacteraemia mice models. BMC Microbiol. 2022 Aug 1;22(1):187. doi: 10.1186/s12866-022-02603-0
- He J, Shi Q, Chen Z, Zhang W, Lan P, Xu Q, Hu H, Chen Q, Fan J, Jiang Y, Loh B, Leptihn S, Zou Q, Zhang J, Yu Y, Hua X. Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae. Drug Resist Updat. 2023 Jan;66:100891. doi: 10.1016/j.drup.2022.100891. Epub 2022 Nov 21.
- Leptihn S, Loh B. Complexity, challenges and costs of implementing phage therapy. Future Microbiol. 2022 Jun;17:643-646. doi: 10.2217/fmb-2022-0054. Epub 2022 Apr 11.
- Liu M, Tian Y, Zaki H E M, Ahmed T, Yao R, Yan C, Leptihnm S, Loh B, Shahid M S, Wang F, Chen J, Li B. Phage resistance reduced the pathogenicity of Xanthomonas oryzae pv. oryzae on rice. Viruses. 2022 Aug 13;14(8):1770. doi: 10.3390/v14081770
- Manohar P, Loganathan A, Nachimuthu R, Loh B, Ma L, Turner D, Leptihn S. Complete Genome Sequence of Pseudomonas Phage Motto. Microbiol Resour Announc. 2022 Nov 17;11(11):e0074022. doi: 10.1128/mra.00740-22. Epub 2022 Oct 12
- Manohar P, Loh B, Namasivayam E, Archana L, Nachimuthu R, Leptihn S. A multiwell-plate Caenorhabditis elegans assay for assessing the therapeutic potential of Bacteriophages against Clinical Pathogens. Microbiol Spectr. 2022 Feb 23;10(1):e0139321. doi: 10.1128/spectrum.01393-21. Epub 2022 Feb 16.
- Manohar P, Royam MM, Loh B, Bozdogan B, Nachimuthu R, Leptihn S. Synergistic Effects of Phage-Antibiotic Combinations against Citrobacter amalonaticus. ACS Infect Dis. 2022 Jan 14;8(1):59-65. doi: 10.1021/acsinfecdis.1c00117. Epub 2022 Jan 3.
- Nachimuthu R, Manohar P, Eniyan K, Archana L, Athira S, Loh B, Ma L, Leptihn S. A lysozyme murein hydrolase with broad-spectrum antibacterial activity from Enterobacter phage myPSH1140. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0050622. doi: 10.1128/aac.00506-22. Epub 2022 Aug 11
- Zhang L, Wang X, Hua X, Yu Y, Lepthin S, Loh B. Therapeutic evaluation of the Acinetobacter baumannii phage Phab24 for clinical use. Virus Res. 2022 Oct 15;320:198889. doi: 10.1016/j.virusres.2022.198889. Epub 2022 Aug 12
- Loh B, Wang X, Hua X, Luo J, Wen T, Zhang L, Ma L, Manohar P, Nachimuthu R, Grainge I, Yu Y, Leptihn S. Complete genomes of Bacteriophages Kaya, Guyu, Kopi and TehO that target clinical strains of Pseudomonas aeruginosa. Microbiol Resour Announc. 2021 Dec 2;10(48):e0104321. doi: 10.1128/MRA.01043-21. Epub 2021 Dec 2.
- Loh B, Zhang L, Hua X, Yu Y, Long M, Wang X, Manohar P, Nachimuthu R, Martins WMBS, Toleman MA, Leptihn S. Complete Genome of the Virulent Klebsiella pneumoniae Phage Geezett Infecting Multidrug-Resistant Clinical Strains. Microbiol Resour Announc. 2021 Dec 2;10(48):e0068521. doi: 10.1128/MRA.00685-21. Epub 2021 Dec 2.
- Wang X, Loh B, Altamirano FG, Yu Y, Hua X, Leptihn S. Colistin-phage combinations decrease antibiotic resistance in A. baumannii via changes in envelope architecture. Emerg Microbes Infect. 2021 Dec;10(1):2205-2219. doi: 10.1080/22221751.2021.2002671
- Loh B, Wang X, Hua X, Chook HW, Ma L, Zhang L, Manohar P, Jin Y, Leptihn S. Complete genome of the lytic bacteriophage Phab24 that infects clinical strains of the nosocomial pathogen Acinetobacter baumannii. Microbiol Resour Announc. 2021 Oct 7;10(40):e0066921. doi: 10.1128/MRA.00669-21. Epub 2021 Oct 7.
- Wu Z, Zhang Y, Xu X, Ahmed T, Yang Y, Loh B, Leptihn S, Yan C, Chen J, Li B. The holin-endolysin lysis system of the OP2-like phage infecting Xanthomonas oryzae pv. oryzae. Viruses. 2021 Sep 28;13(10):1949. doi: 10.3390/v13101949
- Cai H, Zhu Y, Hu D, Li Y, Leptihn S, Loh B, Hua X, Yu Y. Co-harboring of novel hybrid blaKPC−2 plasmid and ICE carrying Tn6203 in multidrug-resistant Pseudomonas aeruginosa. Front Microbiol. 2021 Jul 5;12:674974. doi: 10.3389/fmicb.2021.674974. eCollection 2021.
- Cui Z, Zhang Y, Kakar KU, Kong X, Li R, Loh B, Leptihn S, Li B. Involvement of non-coding RNAs during infection of rice by Acidovorax oryzae. Environ Microbiol Rep. 2021 Aug;13(4):540-554. doi: 10.1111/1758-2229.12982. Epub 2021 Jun 13.
- Wang X, Zhang M, Loh B, Leptihn S, Ahmed T, Li B. A Novel NRPS Cluster, Acquired by Horizontal Gene Transfer from Algae, Regulates Siderophore Iron Metabolism in Burkholderia seminalis R456. Int J Biol Macromol. 2021 Jul 1;182:838-848. doi: 10.1016/j.ijbiomac.2021.04.051. Epub 2021 Apr 19.
- Das R, Kotra K, Singh P, Loh B, Leptihn S, Bajpai U. Alternative Treatment Strategies for Secondary Bacterial and Fungal Infections Associated with COVID-19. Infect Dis Ther. 2022 Feb;11(1):53-78. doi: 10.1007/s40121-021-00559-8. Epub 2021 Nov 22.
- Feng T, Leptihn S, Dong K, Loh B, Zhang Y, Stefan MI, Li M, Guo XK, Cui Z. JD419, a Staphylococcus aureus phage with a unique morphology and broad host range. Front Microbiol. 2021 Apr 22;12:602902. doi: 10.3389/fmicb.2021.602902. eCollection 2021.
- Loh B, Chen J, Manohar P, Yu Y, Hua X, Leptihn S. A Biological Inventory of Prophages in A. baumannii Genomes Reveal Distinct Distributions in Classes, Length and Genomic Positions. Front Microbiol. 2020 Dec 3;11:579802. doi: 10.3389/fmicb.2020.579802. eCollection 2020.
- Loh B, Gondil VS, Manohar P, Khan FM, Yang H, Leptihn S. Encapsulation and Delivery of Therapeutic Phages. Appl Environ Microbiol. 2020 Dec 11;87(5):e01979-20. doi: 10.1128/AEM.01979-20. Online ahead of print.
- Hua X, Xu Q, He J, Zhang D, Chen Q, Zhang L, Loh B, Leptihn S, Wen Y, Higgins P, Zhou Z, Yu Y. The distribution of mutations and hotspots in transcription regulators of resistance-nodulation-cell division efflux pumps in tigecycline non-susceptible Acinetobacter baumannii in China. Int J Med Microbiol. 2020 Dec;310(8):151464. doi: 10.1016/j.ijmm.2020.151464. Epub 2020 Oct 24.
- Fan J, Zhang L, He J, Zhao M, Loh B, Leptihn S, Yu Y, Hua X. Plasmid dynamics of mcr-1-positive Salmonella spp. in a general hospital in China. Front Microbiol. 2020 Dec 22;11:604710. doi: 10.3389/fmicb.2020.604710. eCollection 2020.
- Manohar P, Loh B, Leptihn S. Will the overuse of Antibiotics during the Coronavirus pandemic accelerate Antimicrobial resistance? Infectious Microbes & Diseases. 2020 Sept;2(3):87-88. doi: 10.1097/IM9.0000000000000034
- Manohar P, Loh B, Nachimuthu R, Hua X, Welburn SC, Leptihn S. Secondary Bacterial Infections in Patients with Viral Pneumonia. Front Med (Lausanne). 2020 Aug 5;7:420. doi: 10.3389/fmed.2020.00420. eCollection 2020.
- Manohar P*, Loh B*, Athira S, Nachimuthu R, Hua X, Welburn SC, Leptihn S. Secondary Bacterial Infections During Pulmonary Viral Disease: Phage Therapeutics as Alternatives to Antibiotics? Front Microbiol. 2020 Jun 26;11:1434. doi: 10.3389/fmicb.2020.01434. eCollection 2020.
- Loh B, Leptihn S. A call for a multidisciplinary future of Phage Therapy to combat multi-drug resistant bacterial infections. Infectious Microbes & Diseases. 2020 Mar;2(1),1-2. doi: 10.1097/IM9.0000000000000018
- Loh B, Kuhn A, Leptihn S. The fascinating biology behind phage display: Filamentous Phage Assembly. Mol Microbiol. 2019 May;111(5):1132-1138. doi: 10.1111/mmi.14187. Epub 2019 Mar 26.
- Loh B, Haase M, Mueller L, Kuhn A, Leptihn S. The transmembrane morphogenesis protein gp1 of filamentous phages contains Walker A and Walker B motifs essential for phage assembly. Viruses. 2017 Apr 9;9(4):73. doi: 10.3390/v9040073
- Altrichter S, Haase M, Loh B, Kuhn A, Leptihn S. Mechanism of the spontaneous and directional membrane insertion of a 2-transmembrane ion channel. ACS Chem Biol. 2017 Feb 17;12(2):380-388. doi: 10.1021/acschembio.6b01085. Epub 2016 Dec 21.
- Utturkar SM, Huber H, Leptihn S, Loh B, Brown SD, Stetter KO, Podar M. Draft genome sequence of Pyrodictium occultum PL19, a marine hyperthermophilic species of Archaea that grows optimally at 105°C. Genome Announc. 2016 Feb 25;4(1):e00016-16. doi: 10.1128/genomeA.00016-16
- Jonas S*, Christie M*, Peter D*, Bhandari D, Loh B, Huntzinger E, Weichenrieder O, Izaurralde E. An asymmetric PAN3 dimer recruits a single PAN2 exonuclease to mediate mRNA deadenylation and decay. Nat Struct Mol Biol. 2014 Jul;21(7):599-608. doi: 10.1038/nsmb.2837. Epub 2014 Jun 1.
- Chen Y*, Boland A*, Kuzuoğlu-Öztürk D*, Bawankar P, Loh B, Chang CT, Weichenrieder O, Izaurralde E. A DDX6-CNOT1 Complex and W-Binding Pockets in CNOT9 Reveal Direct Links between miRNA Target Recognition and Silencing. Mol Cell. 2014 Jun 5;54(5):737-50. doi: 10.1016/j.molcel.2014.03.034. Epub 2014 Apr 24.
- Loh B. The CCR4-NOT deadenylation complex functions in the Nonsense Mediated mRNA decay pathway. Eberhard Karls Universität Tübingen, PhD dissertation.
- Chang CT, Bercovich N, Loh B, Jonas S, Izaurralde E. The activation of the decapping enzyme DCP2 by DCP1 occurs on the EDC4 scaffold and involves a conserved loop in DCP1. Nucleic Acids Res. 2014 Apr;42(8):5217-33. doi: 10.1093/nar/gku129. Epub 2014 Feb 8
- Loh B, Jonas S, Izaurralde E. The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2. Genes Dev. 2013 Oct 1;27(19):2125-38. doi: 10.1101/gad.226951.113
- Bawankar P, Loh B, Wohlbold L, Schmidt S, Izaurralde E. NOT10 and C2orf29/NOT11 form a conserved module of the CCR4-NOT complex that docks onto the NOT1 N-terminal domain. RNA Biol. 2013 Feb;10(2):228-44. doi: 10.4161/rna.23018. Epub 2013 Jan 9.
- Vozzolo L, Loh B, Gane PJ, Tribak M, Zhou L, Anderson I, Nyakatura E, Jenner RG, Selwood D, Fassati A. Gyrase B inhibitor impairs HIV-1 replication by targeting Hsp90 and the capsid protein. J Biol Chem. 2010 Dec 10;285(50):39314-28. doi: 10.1074/jbc.M110.155275. Epub 2010 Oct 11.
- Loh B, Vozzolo L, Mok J, Lee C, Fitzmaurice R, Caddick S, Fassati A. Inhibition of HIV-1 replication by isoxazolidine and isoxazole sulfonamides. Chem Biol Drug Des. 2010 May;75(5):461-74. doi: 10.1111/j.1747-0285.2010.00956.x
- Loh B, Wang XW, Bui THH, Luan XL, Ho B, Ding JL. SARM: A novel Toll-like receptor adaptor, is functionally conserved from arthropod to human. Mol Immunol. 2008 Mar;45(6):1732-42. doi: 10.1016/j.molimm.2007.09.030. Epub 2007 Nov 5.