Molekulare Biotechnologie

Publikationen

  • Gröger V, Cynis H. Human endogenous retroviruses and their putative role in the development of autoimmune disorders such as Multiple Sclerosis. Frontiers in Micro­biology 9 (2018), 265. dx.doi.org/10.3389/fmicb.2018.00265
  • Grünberg M, Quandt D, Cynis H, Demuth HU, Kindermann A, Magdolen V, Forssmann WG, Seliger B, Mägert HJ. Kallikrein-related peptidases are activators of the CC chemokine CCL14. European Journal of Immunology 48 (2018), 9, S. 1592-1594. dx.doi.org/10.1002/eji.201747452
  • Kehlen A, Haegele M, Böhme L, Cynis H, Hoffmann T, Demuth HU. N-terminal pyroglutamate formation in CX3CL1 is essential for its full biologic activity. Bioscience Reports, 37 (2017), 4, Art.BSR20170712, 14 S. dx.doi.org/10.1042/BSR20170712 
  • Becker A, Eichentopf R, Sedlmeier R, Cynis H, Koch B, Stephan A, Bäuscher Ch, Kohlmann S, Hoffmann T, Kehlen A, Berg S, Freyse EJ, Osmand A, von Hörsten St, Graubner S, Demuth HU, Schilling S. IsoQC (QPCTL) knock out mice suggest differential substrate conversion by glutaminyl cyclase isoenzymes. Biological Chemistry. 397 (2016), 1, S. 45-55. dx.doi.org/10.1515/hsz-2015-0192
  • Cynis H, Frost JL, Crehan H , Lemere CA. Immunotherapy targeting pyroglutamate-3 Aβ: prospects and challenges. Mol Neurodegener. 2016 Jun 30;11(1):48. DOI dx.doi.org/10.1186/s13024-016-0115-2
  • Cynis H, Funkelstein L, Toneff T, Mosier C, Ziegler M, Koch B, Demuth HU, Hook V. Pyroglutamate-Amyloid-beta and Glutaminyl Cyclase Are Colocalized with Amyloid-beta in Secretory Vesicles and Undergo Activity-Dependent, Regulated Secretion. Neurodegenerative Diseases. 2014; 14(2):85-97. DOI http://dx.doi.org/10.1159/000358430
  • Höfling C, Indrischek H, Höpcke T, Waniek A, Cynis H, Koch B, Schilling S, Morawski M, Demuth HU, Roßner S, Hartlage-Rübsamen M. Mouse strain and brain region-specific expression of the glutaminyl cyclases QC and isoQC. International Journal of Developmental Neuroscience. 2014 Aug; 36:64-73. DOI http://dx.doi.org/10.1016/j.ijdevneu.2014.05.008
  • Morawski M, Schilling S, Kreuzberger M, Waniek A, Jäger C, Koch B, Cynis H, Kehlen A, Arendt T, Hartlage-Rübsamen M, Demuth HU, Roßner S. Glutaminyl cyclase in human cortex: correlation with (pGlu)-amyloid-beta load and cognitive decline in Alzheimer‘s disease. Journal of Alzheimer‘s Disease. 2014;39(2):385-400. DOI dx.doi.org/10.3233/JAD-131535.
  • Cynis H, Kehlen A, Haegele M, Hoffmann T, Heiser U, Fujii M, Shibazaki Y, Yoneyama H, Schilling S, Demuth HU. Inhibition of Glutaminyl Cyclase alleviates CCL2-mediated inflammation of non-alcoholic fatty liver disease. Int. J. Exp. Pathol. 94 (2013), 3:217-225. DOI dx.doi.org/10.1111/iep.12020
  • Nussbaum J, Schilling S, Cynis H, Silva A, Swanson E, Wangsanut T, Tayler K, Wiltgen B, Hatami A, Rönicke R, Reymann K, Hutter-Paier B, Alexandru A, Jagla W, Graubner S, Glabe CG, Demuth HU, Bloom GS. Prion-like behavior and tau-dependent cytotoxicity of pyroglutamylated amyloid peptides. Nature 485 (2012), 7400:651-655. DOI dx.doi.org/10.1038/nature11060
  • Cynis H, Hoffmann T, Friedrich D, Kehlen A, Gans K, Kleinschmidt M, Rahfeld JU, Wolf R, Wermann M, Stephan A, Haegele M, Sedlmeier R, Graubner S, Jagla W, Müller A, Eichentopf R, Heiser U, Seifert F, Quax PH, de Vries MR, Hesse I, Trautwein D, Wollert U, Berg S, Freyse EJ, Schilling S, Demuth HU. The isoenzyme of Glutaminyl Cyclase is an important regulator of monocycte infiltration under inflammatory conditions. EMBO Mol. Med. 3 (2011), 9:545-558. DOI dx.doi.org/10.1002/emmm.201100158
  • Wirths O, Breyhan H, Cynis H, Schilling S, Demuth HU, Bayer TA. Intraneuronal pyroglutamate-Abeta 3-42 triggers neurodegeneration and lethal neurological deficits in a transgenic mouse model. Acta Neuropathol. 118 (2009), 4:487-496. DOI dx.doi.org/10.1007/s00401-009-0557-5
  • Cynis H, Scheel E, Saido T, Schilling S, Demuth HU. Amyloidogenic processing of amyloid precursor protein: evidence of a pivotal role of Glutaminyl Cyclase in generation of pyroglutamate-modified amyloid-beta. Biochemistry 47 (2008), 28:7405-7413. DOI dx.doi.org/10.1021/bi800250p
  • Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M, Kehlen A, Holzer M, Hutter-Paier B, Prokesch M, Windisch M, Jagla W, Schlenzig D, Lindner C, Rudolph T, Reuter G, Cynis H, Montag D, Demuth HU, Rossner S. Glutaminyl Cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer’s disease like pathology. Nat. Med. 14 (2008), 10:1106-1111. DOI dx.doi.org/10.1038/nm.1872
  • Cynis H, Rahfeld JU, Stephan A, Kehlen A, Koch B, Wermann M, Demuth HU, Schilling S. Isolation of an isoenzyme of human Glutaminyl Cyclase: Retention in the Golgi complex suggests involvement in the protein maturation machinery. J. Mol. Biol. 379 (2008), 5:966-980. DOI dx.doi.org/10.1016/j.jmb.2008.03.078
  • Cynis H, Schilling S, Bodnar M, Hoffmann T, Heiser U, Saido TC, Demuth HU. Inhibition of Glutaminyl Cyclase alters pyroglutamate formation in mammalian cells. Biochim. Biophys. Acta 1764 (2006), 10:1618-1625.