Next-generation sequencing

• ST enables the generation of single-cell profiles in historical samples such as formalin-fixed, paraffin-embedded (FFPE), or cryopreserved (FF) tissue.
• ST provides a spatial context for gene expression and elucidates the cellular microenvironment and cell-cell interactions.

Application example:

• The spatial localization of immune cells in tissue can provide crucial information from a prognostic perspective.
  • Studies on response to cancer immunotherapy (Braun et al. *):
  • Comparison of the spatial transcriptome profiles of patients in the treatment and control arms, as well as of patients who respond well or poorly to therapy.
  • Parallel molecular and imaging characterization of the tumor, tumor-infiltrating immune cells, and tumor microenvironment

Available assays:

• Visium HD Spatial Gene Expression (FFPE and cryopreserved tissue)
• Visium Spatial Gene Expression (FFPE and cryopreserved tissue)

* Braun T, Rade M, Merz M, et al. Multiomic profiling of T cell lymphoma after therapy with anti-BCMA CAR T cells and GPRC5D-directed bispecific antibody. Nat Med. 2025 Apr;31(4):1145-1153. doi: 10.1038/s41591-025-03499-9

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