Research areas

Research area immuno-oncology

For a few years now, immuno-oncology has been complementing the classic methods of cancer therapy, radiotherapy, chemotherapy and surgery. Here, medicine makes use of the natural function of the immune system to eliminate foreign and degenerate cells via a wide variety of mechanisms. With the research area immuno-oncology, Fraunhofer IZI supports partners in the development and translation of innovative immunotherapies.

R&D focus

  • ATMP development
  • Preclinical development of cell and gene therapies (efficacy and safety analysis)
  • Cell analysis, assay development and diagnostics
  • GMP process development / process transfer
  • Manufacturing of clinical investigational medicinal products

Research area infectious disease pathology

Infectious diseases continue to pose a global threat to human and animal health. Understanding the spread, pathogenesis and possibilities of diagnosis, is essential for their effective control. With the research area infectious disease pathology, Fraunhofer IZI supports partners in the development and translation of technologies for research, diagnostics, prevention and therapy of infectious diseases.

R&D focus

  • Preclinical development of active agents and vaccines (efficacy and safety analysis)
  • Vaccine technologies
  • Drug and material testing
  • Assays and diagnostics

Business fields

The Fraunhofer IZI offers R&D services for pharmaceutical, biotechnological and medical technology companies as well as for partners from research institutions, hospitals and diagnostic laboratories.

Business field cell and gene therapy

Preclinical development and testing

  • Target identification and validation
  • ATMP design
  • Vector development
  • In vivo models and model development
  • GLP studies (efficacy & toxicity studies)
  • Cell analysis
  • Risk assessment
  • Companion diagnostics

Process development and manufacturing

  • GMP process design
  • Automation solutions
  • GMP process transfer
  • Manufacturing authorization
  • Proof-of-concept studies
  • Pharmaceutical manufacturing incl. quality management (GMP)

Business field drugs and vaccines

Preclinical development and testing

  • Drug / vaccine design
  • Target validation / proof-of-concept studies
  • In vivo studies and model development up to Biosafety Level 3
  • Companion diagnostics
  • Non-Clinical Development
  • Drug / vaccine characterization
  • Efficacy & toxicity studies

Process development

  • Design of manufacturing processes and analytical methods
  • Development of new manufacturing technologies

Business field molecular diagnostics and immunodiagnostics

Assay Development

  • Process-integrable assays
  • Molecular binders (e.g. peptides, DNA) 

Biomarker development and bioinformatics

  • Next-generation sequencing
  • Identification of disease-associated biomarkers
  • Biostatistics


  • AI-assisted image analysis and imaging

Microfluidics and point-of-care systems

  • Rapid prototyping of microfluidic structures
  • Development of complete diagnostic systems
  • Highly sensitive lateral flow assays

Business field extracorporeal therapies

Technology development and optimization

  • Albumin dialysis
  • Cryo-based detoxification procedures / mobile dialysis
  • Cell-based extracorporeal therapies

Component development / testing

  • Adsorbers
  • Filters
  • Bioreactors