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Hitchhiker’s Guide to the Cell: Fraunhofer IZI researches to improve imaging methods for organoids

On 1st March 2020, a new research project was launched at the Fraunhofer Institute for Cell Therapy and Immunology (IZI). Imaging of living cells is to be improved by means of viral and bacterial targeting sequences. The project is supported by the VolkswagenStiftung.
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Significant PIONEER milestone – First two datasets uploaded into the PIONEER Big Data platform

PIONEER is a European Network of Excellence for Big Data in Prostate Cancer, consisting of 32 partners across 9 countries, among them Fraunhofer IZI. In an important step forward the first datasets have been transferred into the PIONEER Big Data platform by PIONEER partner Erasmus University Medical Centre (MC). Through the application of Big Data and the analyses of real-world evidence PIONEER aims to change the prostate cancer landscape to improve the health and social care received by all prostate cancer patients and their families. Fraunhofer IZI works in the framework of the PIONEER project on the topics data harmonisation of transcriptome-wide expression studies as well as statistical data analyses to identify and confirm biomarkers.
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Collaboration between Fraunhofer IZI and Halle University Hospital to develop therapeutic antibodies for HERV-associated autoimmune and tumor diseases

Human endogenous retroviruses (HERVs) and, more specifically, their envelope proteins are suspected of transporting diseases such as multiple sclerosis, rheumatism and tumor diseases. However, the actual function of these specific factors remains to be seen. Cellular damage and the misdirected stimulation of the immune system caused by HERV are assumed to be disease mechanisms. A joint research project between the Fraunhofer Institute for Cell Therapy and Immunology IZI and Halle University Hospital is expected to deliver new insights based on the characterization of HERV envelope proteins. The aim is to develop therapeutic antibodies for HERV-associated autoimmune and tumor diseases.
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Making novel therapeutics safer: Interdisciplinary EU consortium develops innovative model systems for the evaluation of immunomodulating therapeutics

Fraunhofer IZI takes lead on EU project developing highly innovative model systems to evaluate immunomodulatory therapeutic agents. The development of immunomodulatory agents and therapies has received fresh impetus following the latest successes in immuno-oncology. And cancer medicine is not the only area where cell and gene therapies are increasingly taking hold as alternatives or complementary to classic, low-molecular drugs and biologicals.
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