Fraunhofer Institute for Cell Therapy and Immunology IZIClinical Gene Transfer
The Clinical Gene Transfer Unit researches and develops technologies for the virus-free genetic manipulation of cells for therapeutic use. One focus is the further development and application of sleeping beauty transposon technology as a basis for the development of novel gene therapies. The group optimizes, characterizes and optimizes the molecular characteristics of SB transposon systems. Various in vivo models are available for preclinical development, which can be used to investigate the efficacy and safety of gene therapies.
Competencies
- Genome engineering
- Gene insertion
- Transposon technologies
- Non-viral gene delivery
- CAR-T cell engineering with Sleeping Beauty transposon vectors
- In vivo models of genetic diseases
- Preclinical gene therapy of blood diseases
- Genetic engineering of hematopoietic stem cells
- iPSC technologies and disease modeling
- Gene editing with CRISPR/Cas technologies