Automated production technologies for mRNA-based drugs

Nanoparticle character­ization, analytics and formulation for biomedical applications

Characterization

  • Optimization and implementation of (inline) nano- and bioanalytics
  • Formulation analysis; e.g.,
    • Determination of size, sizedistribution
    • Zetapotential
    • Morphology 
    • Encapsulation
    • In vitro toxicity 
    • In vitro efficacy 
    • RNA analytic
    • Lipid analytic
  • Protocol assistance 
  • Scientific advice
Automated synthesis of different nanocarrier and their characterization.
Cryo-TEM image of lipidnanoparticles.
Cryo-TEM image of liposomes.
Cryo-TEM image of coated magnetnanoparticles.

Industrial collaboration & partnering

  • Design, construction and manufacturing of prototypes
  • Customized building of formulation and analytic modules
  • Technology transfer and licensing

Formulation

  • Scalable formulation system for screening and process development 
  • Process development for continuous manufacturing of micromixer assisted nanocarriers
  • Versatile nanocarrier systems for therapeutic and diagnostic applications