Publication list 2023
- Adamowicz K, Arend L, Maier A, Schmidt J R, Kuster B, Tsoy O, Zolotareva O, Baumbach J, Laske T. Proteomic meta-study harmonization, mechanotyping and drug repurposing candidate prediction with ProHarMeD. NPJ Syst Biol Appl 2023, 9(1): 49. doi: 10.1038/s41540-023-00311-7
- Agarwal B, Cañizares RB, Saliba F, Ballester MP, Tomescu DR, Martin D, Stadlbauer V, Wright G, Sheikh M, Morgan C, Alzola C, Lavin P, Green D, Kumar R, Sacleux SC, Schilcher G, Koball S, Tudor A, Minten J, Domenech G, Aragones JJ, Oettl K, Paar M, Waterstradt K, Bode-Boger SM, Ibáñez-Samaniego L, Gander A, Ramos C, Chivu A, Stange J, Lamprecht G, Sanchez M, Mookerjee RP, Davenport A, Davies N, Pavesi M, Andreola F, Albillos A, Cordingley J, Schmidt H, Carbonell-Asins JA, Arroyo V, Fernandez J, Mitzner S, Jalan R. Randomized, controlled clinical trial of the DIALIVE liver dialysis device versus standard of care in patients with acute-on- chronic liver failure. J Hepatol. 2023, Jul;79(1): 79-92. doi: 10.1016/j.jhep.2023.03.013
- Ammar D, Schapitz I, Luu M, Hudecek M, Meyer M, Taps T, Schröder B, Ivics Z, Sanges C, Franz P, Koehl U, Negre H, Johanna I, Awigena-Cook J. Accelerating development of engineered T cell therapies in the EU: current regulatory framework for studying multiple product versions and T2EVOLVE recommendations. Front Immunol. 2023, Nov, 14: 1280826. doi: 10.3389/fimmu.2023.1280826
- Anders I M, Schimmelpfennig C, Wiedemann K, Löffler D, Kämpf C, Blumert C, Reiche K, Kunz M, Anderegg U, Simon J-C, Ziemer M. Atypical fibroxanthoma and pleomorphic dermal sarcoma – gene expression analysis compared with undifferentiated cutaneous squamous cell carcinoma. J Dtsch Dermatol Ges 2023, 21 (5): 482-491. doi: 10.1111/ddg.15006
- Auw N von, Serfling R, Kitte R, Hilger N, Zhang C, Gebhardt C, Dünkel A, Franz P, Köhl U, Fricke S, Tretbar SU. Comparison of two lab-scale protocols for enhanced mRNA-based CAR-T cell generation and functionality. Sci Rep 2023, 13 (1), article 18160. doi: 10.1038/s41598-023-45197-x
- Bache M, Kadler F, Struck O, Medenwald D, Ostheimer C, Güttler A, Keßler J, Kappler M, Riemann A, Thews O, Seliger B, Vordermark D. Correlation between circulating miR-16, miR-29a, miR-144 and miR-150, and the radiotherapy response and survival of non-small-cell lung cancer patients. Int J Mol Sci 2023, 24 (16), article 12835. doi: 10.3390/ijms241612835
- Barendrecht S, Schreurs A, Geißler S, Sabanov V, Ilse V, Rieckmann V, Eichentopf R, Künemund A, Hietel B, Wussow S, Hoffmann K, Körber-Ferl K, Pandey R, Carter G W, Demuth H-U, Holzer M, Roßner S, Schilling S, Preuss C, Balschun D, Cynis H. A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice. Alzheimers Res Ther 2023, 15 (1), article 16. doi: 10.1186/s13195-022-01144-y
- Bentler M, Hardet R, Ertelt M, Rudolf D, Kaniowska D, Schneider A, Vondran F W R, Schoeder C T, Delphin M, Lucifora J, Ott M, Hacker U T, Adriouch S, Büning H. Modifying immune responses to adeno-associated virus vectors by capsid engineering. Mol Ther Methods Clin Dev 2023, 30: 576-592. doi: 10.1016/j.omtm.2023.08.015
- Blache U, Tretbar S, Koehl U, Mougiakakos D, Fricke S. CAR T cells for treating autoimmune diseases. RMD open 2023, 9 (4): e002907. doi: 10.1136/rmdopen-2022-002907
- Blaudszun A-R, Kim W J, Um W, Yoon H Y, Shim M K, Kim K. Adoptive transfer of photosensitizer-loaded cytotoxic T cells for combinational photodynamic therapy and cancer immuno-therapy. Pharmaceutics. 2023,15 (4): 1295. doi: 10.3390/pharmaceutics15041295
- Böhm K, Schulze-Niemand E, Kähne T, Siddiqui E, Täger C, Ramsbeck D, Buchholz M, Naumann M. Synthesis and structure–activity relationships of USP48 deubiquitinylase inhibitors. Arch Pharm 2023, 356 (7), article: 2200661. doi: 10.1002/ardp.202200661
- Broséus J, Hergalant S, Vogt J, Tausch E, Kreuz M, Mottok A, Schneider C, Dartigeas C, Roos-Weil D, Quinquenel A, Moulin C, Ott G, Blanchet O, Tomowiak C, Lazarian G, Rouyer P, Chteinberg E, Bernhart SH, Tournilhac O, Gauchotte G, Lomazzi S, Chapiro E, Nguyen-Khac F, Chery C, Davi F, Hunault M, Houlgatte R, Rosenwald A, Delmer A, Meyre D, Béné MC, Thieblemont C, Lichter P, Ammerpohl O, Guéant JL; ICGC MMML-Seq Consortium; Guièze R, Martin-Subero JI, Cymbalista F, Feugier P, Siebert R, Stilgenbauer S. Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis. Nat Commun. 2023, 14 (1): 309. doi: 10.1038/s41467-022-34642-6
- Caballero L R, Treudler R, Delaroque N, Simon J C, Kern K, Szardenings M. Peptide epitopes as biomarkers of soya sensitization in rBet v 1 immunotherapy of birch-related soya allergy. Clin Exp Allergy 2023, 53 (3): 316-326. doi: 10.1111/cea.14224
- Chilingaryan G, Izmailyan R, Grigoryan R, Shavina A, Arabyan E, Khachatryan H, Abelyan N, Matevosyan M, Harutyunyan V, Manukyan G, Hietel B, Shtro A, Danilenko D, Zakaryan H. Advanced virtual screening enables the discovery of a host-targeting and broad-spectrum antiviral agent. Antiviral Res 2023, 217, article 105681. doi: 10.1016/j.antiviral.2023.105681
- Ciulean I S, Fischer J, Quaiser A, Bach C, Abken H, Tretbar U S, Fricke S, Köhl U, Schmiedel D, Grunwald T. CD44v6 specific CAR-NK cells for targeted immunotherapy of head and neck squamous cell carcinoma. Front Immunol 2023, 14: 1290488. doi: 10.3389/fimmu.2023.1290488
- Dzhambazov B, Batsalova T, Merky P, Lange F, Holmdahl R. NIH/3T3 fibroplasts selectively activate T cells specific for posttranslationally modified collagen type II. Int J Mol Sci 2023, 24 (13), article: 10811. doi: 10.3390/ijms241310811
- Eberlein V, Ahrends M, Bayer L, Finkensieper J, Besecke J K, Mansuroglu Y, Standfest B, Lange F, Schopf S, Thoma M, Dressman J, Hesse C, Ulbert S, Grunwald T. Mucosal application of a low-energy electron inactivated respiratory syncytial virus vaccine shows protective efficacy in an animal model. Viruses 2023, 15 (9), article 1846. doi: 10.3390/v15091846
- Engel C, Wirkner K, Zeynalova S, Baber R, Binder H, Ceglarek U, Enzenbach C, Fuchs M, Hagendorff A, Henger S, Hinz A, Rauscher FG, Reusche M, Riedel-Heller SG, Röhr S, Sacher J, Sander C, Schroeter ML, Tarnok A, Treudler R, Villringer A, Wachter R, Witte AV, Thiery J, Scholz M, Loeffler M; LIFE-Adult-Study working group. Cohort Profile: The LIFE-adult-study. Int J Epidemiol 2023, 52 (1): E66 - E791. doi: 10.1093/ije/dyac114
- Feigl F F, Stahringer A, Peindl M, Dandekar G, Köhl U, Fricke S, Schmiedel D. Efficient redirection of NK cells by genetic modification with chemokine receptors CCR4 and CCR2B. Int J Mol Sci 2023, 24 (4), article 3129. doi: 10.3390/ijms24043129
- Finkensieper J, Mayerle F, Rentería-Solís Z, Fertey J, Makert G R, Lange F, Besecke J, Schopf S, Poremba A, König U, Standfest B, Thoma M, Daugschies A, Ulbert S. Apicomplexan parasites are attenuated by low energy electron irradiation in an automated microfluidic system and protect against infection with Toxoplasma gondii. Parasitol Res, 2023, 122(8): 1819-1832. doi: 10.1007/s00436-023-07880-w
- Freitag J S, Möser C, Belay R, Altattan B, Grasse N, Pothineni B K, Schnauß J, Smith D M. Integration of functional peptides into nucleic acid-based nanostructures. Nanoscale 2023, 15 (17): 7608-7624. doi: 10.1039/d2nr05429a
- Glaser M, Mollenkopf P, Prascevic D, Ferraz C, Käs J A, Schnauß J, Smith D M. Systematic altering of semiflexible DNA-based polymer networks via tunable crosslinking. Nanoscale. 2023, 15 (16): 7374-7383. doi: 10.1039/d2nr05615a
- Glatte B, Wenk K, Grahnert A, Friedrich M, Merz M, Vucinic V, Fischer L, Reiche K, Alb M, Hudecek M, Franz P, Fricke S, Platzbecker U, Koehl U, Sack U, Boldt A, Hauschildt S, Weiss R. Teclistamab impairs detection of BCMA CAR-T cells. Blood Adv 2023, 7 (15): 3842-3845. doi: 10.1182/bloodadvances.2023009714
- Han Y, Zhao J, Chao Z, Liang K, Zhang C, Jiang L, Jiao Z, Bai F, Tarnok A, You Z. Imaging flow cytometry using linear array spot excitation. Device 2023, 1 (6): 100124. doi: 10.1016/j.device.2023.100124
- He J, Shi Q, Chen Z, Zhang W, Lan P, Xu Q, Hu H, Chen Q, Jianzhong F, Jiang Y, Loh B W-C, Lepthin S, Zou Q, Zhang J, Yu Y, Hua X. Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae. Drug Resist Updat. 2023, 66: 100891. doi: 10.1016/j.drup.2022.100891
- Hilali N, Hangouët M, Bausells J, Kern K, Ramirez-Caballero L, Szardenings M, Polonschii Cristina, Mohammadi H, Amime A, Zine N, Errachid A. Fast impedimetric immunosensing of IgGs associated with peanut and hazelnut allergens. Biosens Bioelectron 2023, 242, article: 115612. doi: 10.1016/j.bios.2023.115612
- Hoen L, Pfeffer D, Schmidt J R, Kraft J, Hildebrand J, Kalkhof S. Hydration status of geriatric patients is associated with changes in plasma proteome, especially in proteins involved in coagulation. Nutrients 2023, 15 (17), article 3789. doi: 10.3390/nu15173789
- Issmail L, Ramsbeck D, Jäger C, Henning T, Kleinschmidt M, Buchholz M, Grunwald T. Identification and evaluation of a novel tribenzamide derivative as an inhibitor targeting the entry of the respiratory syncytial virus. Antiviral Res 2023, article 105547. doi: 10.1016/j.antiviral.2023.105547
- Kern K, Delaroque N, Boysen A, Puder M, Wendt R, Kölsch A, Ehrentreich-Förster E, Staerk K, Andersen T E, Andersen K, Lund L, Szardenings M. Glycosylation of bacterial antigens changes epitope patterns. Front Immunol 2023, 14: 1258136. doi: 10.3389/fimmu.2023.1258136
- Kiefer N, Nichterlein M, Reiß F, Runge M, Biermann U, Wieland T, Noll M, Kalkhof S. Eluates from façades at the beginning of their service time affect aquatic and sediment organisms. Sci Total Environ 2023, 906, article 167531. doi: 10.1016/j.scitotenv.2023.167531
- Kitte R, Rabel M, Geczy R, Park S, Fricke S, Koehl U, Tretbar SU. Lipid nanoparticles outperform electroporation in mRNA-based CAR T cell engineering. Mol Ther Methods Clin Dev, 2023, 31: 101139. doi: 10.1016/j.omtm.2023.101139
- Klinkmann G, Waterstradt K, Klammt S, Schnurr K, Schewe J-C, Wasserkort R, Mitzner S. Exploring albumin functionality assays: a pilot study on sepsis evaluation in intensive care medicine. Int J Mol Sci 2023, 24 (16), article 12551. doi: 10.3390/ijms241612551
- Klinkmann G, Wild T, Heskamp B, Doss F, Doss S, Milej M, Thiele L-M, Goudeva L, Blasczyk R, Reuter D, Altrichter J, Mitzner S. Extracorporeal therapy of sepsis by purified granulocyte concentrates—ex vivo circulation model. Artifical Organs 2023, 47 (7): 1151-1162. doi: 10.1111/aor.14507
- Lozada-Chávez I, Lozada-Chávez A N, Stadler P F, Prohaska S J. The genomes of complex multicellular organisms on Earth are characterized by high intron-richness. Revista mexicana de astronomía y astrofísica 2023, 55. doi: 10.22201/ia.14052059p.2023.55.14
- Massa C, Seliger B. Combination of multiple omics techniques for a personalized therapy or treatment selection. Front Immunol 2023, 14, article 1258013. doi: 10.3389/fimmu.2023.1258013
- Massa C, Wang Y, Marr N, Seliger B. Interferons and resistance mechanisms in tumors and pathogen-driven diseases - focus on the major histocompatibility complex (MHC) antigen processing pathway. Int J Mol Sci 2023, 24 (7), article 6736. doi: 10.3390/ijms24076736
- Messer E K, Meyer A L, Klaeske K, Sieg F, Eifert S, Schmiedel D, Haunschild J, Jawad K, Saeed D, Hildebrandt L, Borger M A, Dieterlen M-T. The impact of obesity on T and NK cells after LVAD implantation. Obes Facts 2023, 16 (4): 364-373. doi: 10.1159/000530174
- Mollenkopf P, Prascevic D, Bayerl T M, Käs J A, Schnauß J. Heavy water induces bundling in entangled actin networks. RSC Adv 2023, 13 (35): 24795-24800. doi: 10.1039/d3ra03917j
- Mötzing M, Blüher M, Grunwald T, Hoffmann R. Immunological quantitation of the glycation site Lysine‐414 in serum albumin in human plasma samples by indirect ELISA using highly specific monoclonal antibodies. ChemBioChem 2023, online ahead of print, article e202300550. doi: 10.1002/cbic.202300550
- Mytzka N, Arbaciauskaite S, Sandetskaya N, Mattern K, Kuhlmeier D. A fully integrated duplex RT‑LAMP device for the detection of viral infections. Biomed Microdevices 2023, 25 (4), article 36. doi: 10.1007/s10544-023-00676-w
- Nowak J, Bentele M, Kutle I, Zimmermann K, Lühmann J K, Steinemann D, Kloess S, Köhl U, Roßberg W, Ahmed A, Schaudien D, Neubert L, Kamp J-C, Kuehnel M P, Warnecke A, Schambach A, Morgan M. CAR-NK cells targeting HER1 (EGFR) show efficient anti-tumor activity against head and neck squamous cell carcinoma (HNSCC). Cancers (Basel) 2023, 15 (12), article 3169. doi: 10.3390/cancers15123169
- Quint I, Simantzik J, Kaiser L, Laufer S, Csuk R, Smith D, Kohl M, Deigner H-P. Ready-to-use nanopore platform for label-free small molecule quantification: ethanolamine as first example. Nanomedicine 2023, online aheas of print, article 102724. doi: 10.1016/j.nano.2023.102724
- Rade M, Böhlen S, Neuhaus V, Löffler D, Blumert C, Merz M, Köhl U, Dehmel S, Sewald K, Reiche K. A time-resolved meta-analysis of consensus gene expression profiles during human T-cell activation. Genome Biol. 2023, 24(1): 287. doi: 10.1186/s13059-023-03120-7
- Rauch-Wirth L, Renner A, Kaygisiz K, Zimmermann L, Rodríguez Alfonso AA, Schütz D, Wiese S, Ständker L, Weil T, Schmiedel D, Münch J. Optimized peptide nanofibrils as efficient transduction enhancers for in vitro and ex vivo gene transfer. Front Immunol. 2023, 14:1270243. doi: 10.3389/fimmu.2023.1270243
- Rentschler S, Borgolte M, Filbert A, Laufer S, Deigner H-P. Highly efficient β-lactamase assay applying poly-dimethylacrylamide-based surface functionalization with β-lactam antibiotics and β-lactamase inhibitors. Lab Chip 2023, 23 (24): 5120-5130. doi: 10.1039/d3lc00682d
- Reus P, Guthmann H, Uhlig N, Agbaria M, Issmail L, Eberlein V, Nordling-David MM, Jbara-Agbaria D, Ciesek S, Bojkova D, Cinatl J, Burger-Kentischer A, Rupp S, Zaliani A, Grunwald T, Gribbon P, Kannt A, Golomb G. Drug repurposing for the treatment of COVID-19: Targeting nafamostat to the lungs by a liposomal delivery system. J Control Release 2023, 364: 654-671. doi: 10.1016/j.jconrel.2023.10.050
- Salti H, Kramer L, Nelz S-C, Lorenz M, Breitrück A, Hofrichter J, Frank M, Schulz K, Mitzner S, Wasserkort R. Decellularization of precision-cut kidney slices-application of physical and chemical methods. Biomed Mater 2023, 18 (2), article 025004. doi: 10.1088/1748-605X/acb02e
- Schäfer H, Subbarayan K, Massa C, Vaxevanis C, Mueller A, Seliger B. Correlation of the tumor escape phenotype with loss of PRELP expression in melanoma. J Transl Med 2023, 21, article 643. doi: 10.1186/s12967-023-04476-x
- Schimmelpfennig C, Rade M, Füssel S, Löffler D, Blumert C, Bertram C, Borkowetz A, Otto D J, Puppel S-H, Hönscheid P, Sommer U, Baretton G B, Köhl U, Wirth M, Thomas C, Horn F, Kreuz M, Reiche K. Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer. BMC Cancer 2023, 23, article 575. doi: 10.1186/s12885-023-11019-6
- Schmidt J R, Haupt J, Riemschneider S, Kämpf C, Löffler D, Blumert C, Reiche K, Koehl U, Kalkhof S, Lehmann J. Transcriptomic signatures reveal a shift towards an anti-inflammatory gene expression profile but also the induction of type I and type II interferon signaling networks through aryl hydrocarbon receptor activation in murine macrophages. Front Immunol 2023, 14: article number 1156493. doi: 10.3389/fimmu.2023.1156493
- Schulz J, Schilling E, Fabian C, Zenclussen A C, Stojanovska V, Claus C. Dissecting rubella placental infection in an In vitro trophoblast model. Int J Mol Sci, 2023, 24(9), article number 7894. doi: 10.3390/ijms24097894
- Szardenings M, Delaroque N, Kern K, Ramirez-Caballero L, Puder M, Ehrentreich-Förster E, Beige J, Zürner S, Popp G, Wolf J, Borte S. Detection of antibodies against endemic and SARS-CoV-2 coronaviruses with short peptide epitopes. Vaccines 2023, 11 (9), article 1403, doi: 10.3390/vaccines11091403
- Tan K, Jäger C, Geissler S, Schlenzig D, Buchholz M, Ramsbeck D. Synthesis and structure–activity relationships of pyrazole-based inhibitors of meprin α and β. J Enzyme Inhib Med Chem. 2023, 38 (1): 2165648. doi: 10.1080/14756366.2023.2165648
- Tanuchai B, Ji L, Schröder O, Gawol S J, Geissler A, Wahdan S F M, Buscot F, Kalkhof S, Schulze E-D, Noll M, Purahong W. Fate of a biodegradable plastic in forest soil: dominant tree species and forest types drive changes in microbial community assembly, influence the composition of plastisphere, and affect poly(butylene succinate-co-adipate) degradation. Sci Total Environ 2023, 873: article 162230. doi: 10.1016/j.scitotenv.2023.162230
- Thaher B A, Al-Masri I, Wahedy K, Morjan R, Aliwaini S, Al atter I M, Elmabhouh A A, Al Ibwaini A K, Alkhaldi S L, Qeshta B, Jacob C, Deigner H-P. Synthesis and bioassay of 3-Aryl -1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]- triazin-4(3H)-ones as anti-cancer agents. Naunyn Schmiedebergs Arch Pharmacol. 2023, 396(8): 1797-1810. doi: 10.1007/s00210-023-02433-5
- Tong L, Kremer V, Neo SY, Liu Y, Chen Y, Wagner AK, Yang Y, Chen Z, Seitz C, Tobin NP, Ligtenberg MA, Alici E, Chen X, Haglund F, Seliger B, Harmenberg U, Colón E, Plogell AS, Liu LL, Lundqvist A. Renal cell carcinoma escapes NK cell-mediated immune surveillance through the downregulation of DNAM-1. Cancer Commun (Lond.) 2023, 43 (7): 855-859. doi: 10.1002/cac2.12446
- Vaxevanis C K, Bauer M, Subbarayan K, Friedrich M, Massa C, Biehl K, Al-Ali H K, Wickenhauser C, Seliger B. Biglycan as a mediator of proinflammatory response and target for MDS and sAML therapy. OncoImmunology 2023, 12 (1), article 2152998. doi: 10.1080/2162402X.2022.2152998
- Vogelsberg E, Moors M, Sorokina A S, Ryndyk D A, Schmitz S, Freitag J S, Subbotina A V, Heine T, Abel B, Monakhov K Y. Solution-processed formation of DNA-origami-supported polyoxometalate multi-level Switches with countercation-controlled conductance tunability. Chem Mater 2023, 35 (14). doi: 10.1021/acs.chemmater.3c00776
- Wang N, Lei T, Zhu Y, Li Y, Cai H, Zhang P, Leptihn S, Zhou J, Ke H, Gao B, Feng Y, Hua X, Qu T. Characterization of two novel VIM-type metallo-β-lactamases, VIM-84 and VIM-85, associated with the spread of IncP-2 megaplasmids in Pseudomonas aeruginosa. Microbiol Spectr 2023, 11 (5), article e0154423. doi: 10.1128/spectrum.01544-23
- Wang Y, He J, Sun L, Jiang Y, Hu L, Leptihn S, Zhu P, Fu X, Yu Y, Hua X. IS26 mediated blaCTX-M-65 amplification in Escherichia coli increase the antibiotic resistance to cephalosporin in vivo. J Glob Antimicrob Resist 2023, 35: 202-209. doi: 10.1016/j.jgar.2023.09.018
- Wang Y, Jasinski-Bergner S, Wickenhauser C, Seliger B. Cancer immunology: immune escape of tumors - expression and regulation of HLA class I molecules and its role in immunotherapies. Adv Anat Pathol 2023, 30 (3): 148-159. doi: 10.1097/PAP.0000000000000389
- Weiß R, Issmail L, Rockstroh A, Grunwald T, Fertey J, Ulbert S. Immunization with different recombinant West Nile virus envelope proteins induces varying levels of serological cross-reactivity and protection from infection. Front Cell Infect Microbiol, 2023, 13: 1279147. doi: 10.3389/fcimb.2023.1279147
- Zhang X, Greiser S, Roy U, Lange F, Gorkum R v, Fournelle M, Speicher D, Tretbar S, Melzer A, Landgraf L. Evaluation of a developed MRI-guided focused ultrasound system in 7 T small animal MRI and proof-of-concept in a prostate cancer xenograft model to improve radiation therapy. Cells 2023, 12 (3), article 481, doi: 10.3390/cells12030481