Annual report 2022

Publications

• Alaneed R, Naumann M, Pietzsch M, Kressler J. Microbial transglutaminase-mediated formation of erythropoietin-polyester conjugates. J Biotechnol. 2022 Feb 20;346:1-10. doi: 10.1016/j.jbiotec.2022.01.001. Epub 2022 Jan 15. 
• Allelein S, Aerchlimann K A, Roesch G, Khajehamiri R, Koelsch A, Freese C, Kuhlmeier D. Prostate-specific membrane antigen (PSMA)-positive extracellular vesicles in urine - a potential liquid biopsy strategy for prostate cancer diagnosis? Cancers (Basel). 2022 Jun 17;14(12):2987. doi: 10.3390/cancers14122987
• Arbaciauskaite S, Babakhani P, Sandetskaya N, Vitkus D, Jancoriene L, Karosiene D, Karciauskaite D, Zablockiene B, Kuhlmeier D. Self-sampled gargle water direct RT-LAMP as a screening method for the detection of SARS-CoV-2 infections. Diagnostics (Basel). 2022 Mar 22;12(4):775. doi: 10.3390/diagnostics12040775 
• Arteaga V G, Demand V, Kern K, Strube A, Szardenings M, Muranyi I, Eisner P, Schweiggert-Weisz U. Enzymatic hydrolysis and fermentation of pea protein isolate and its effects on antigenic proteins, functional properties, and sensory profile. Foods. 2022 Jan 4;11(1):118. doi: 10.3390/foods11010118 
• Arumugam S N, Manohar P, Sukumaran S, Sadagopan S, Loh B, Leptihn S, Nachimuthu R. Antibacterial efficacy of lytic phages against multidrug-resistant Pseudomonas aeruginosa infections in bacteraemia mice models. BMC Microbiol. 2022 Aug 1;22(1):187. doi: 10.1186/s12866-022-02603-0 
• Bathini P, Sun T, Schenk M, Schilling S, McDannold N J, Lemere C A. Acute effects of focused ultrasound-induced blood-brain barrier opening on anti-pyroglu3 abeta antibody delivery and immune responses. Biomolecules. 2022 Jul 6;12(7):951. doi: 10.3390/biom12070951 
• Bäumer N, Scheller A, Wittmann L, Faust A, Apel M, Nimmagadda SC, Geyer C, Grunert K, Kellmann N, Peipp M, Kailayangiri S, Ezequiel Gutierrez Suburu ME, Strassert CA, Schenk M, Greune L, Rüter C, Dersch P, Hartmann W, Rossig C, Neri D, Müller-Tidow C, Schwöppe C, Schliemann C, Khandanpour C, Lenz G, Berdel WE, Bäumer S. Electrostatic anti-CD33-antibody-protamine nanocarriers as platform for a targeted treatment of acute myeloid leukemia. J Hematol Oncol. 2022 Dec 1;15(1):171. doi: 10.1186/s13045-022-01390-5 
• Bayly-Jones C, Lupton C J, Fritz C, Venugopal H, Ramsbeck D, Wermann M, Jaeger C, Marco A de, Schiling S, Schlenzig D, Whisstock J C. Helical ultrastructure of the metalloprotease meprin α in complex with a small molecule inhibitor. Nat Commun. 2022 Oct 19;13(1):6178. doi: 10.1038/s41467-022-33893-7 
• Beckmann L, Tretbar S, Kitte R, Tretbar M. Anticancer activity of natural and semi-synthetic drimane and coloratane sesquiterpenoids. Molecules. 2022 Apr 13;27(8):2501. doi: 10.3390/molecules27082501 
• Berneck B S, Rockstroh A, Barzon L, Sinigaglia A, Vocale C, Landini M P, Rabenau H F, Schmidt-Chanasit J, Ulbert S. Serological differentiation of West Nile virus- and Usutu virus-induced antibodies by envelope proteins with modified cross-reactive epitopes. Transbound Emerg Dis. 2022 Sep;69(5):2779-2787. doi: 10.1111/tbed.14429. Epub 2022 Jan 10 
• Beyer K, Straten V, Remmers S, MacLennan S, MacLennan S, Gandaglia G, Willemse P-P M, Herrera R, Omar M I, Russel B, Huber J, Kreuz M, Asiimwe A, Abbott T, Briganti A, Hemelrijck M van, Roobol M J, Prias Consortium, Erspc Rotterdam Study Group, Pioneer Consortium. Secondary treatment for men with localized prostate cancer: a pooled analysis of PRIAS and ERSPC-Rotterdam data within the PIONEER data platform. J Pers Med. 2022 May 5;12(5):751. doi: 10.3390/jpm12050751 
• Biadglegne F, Schmidt J R, Engel K M, Lehmann J, Lehmann R T, Reinert A, Koenig B, Schiller J, Kalkhof S, Sack U. Mycobacterium tuberculosis affects protein and lipid content of circulating exosomes in infected patients depending on Tuberculosis disease state. Biomedicines. 2022 Mar 27;10(4):783. doi: 10.3390/biomedicines10040783 
• Blache U, Ford EM, Ha B, Rijns L, Dankers PYW, Kloxin AM, Snedeker JG, Gentleman E. Engineered hydrogels for mechanobiology. Nature Reviews Methods Primer 2 (2022) 
• Blache U, Popp G, Duenkel A, Koehl U, Fricke S. Potential solutions for manufacture of CAR T cells in cancer immunotherapy. Nat Commun. 2022 Sep 5;13(1):5225. doi: 10.1038/s41467-022-32866-0 
• Bluhm A, Schrempel S, Moceri S, Stieler J, Feja M, Schilling S, Schulze A, Hörsten S von, Hartlage-Rübsamen M, Richter F, Roßner S. Alpha synuclein processing by MMP-3 - implications for synucleinopathies. Behav Brain Res. 2022 Sep 26;434:114020. doi: 10.1016/j.bbr.2022.114020. Epub 2022 Jul 21 
• Bluhm A, Schrempel S, Schilling S, Hoersten, S von, Schulze A, Roßner S, Hartlage-Ruebsamen M. Immunohistochemical demonstration of the pGlu79 α-synuclein fragment in Alzheimer’s disease and its Tg2576 mouse model. Biomolecules. 2022 Jul 20;12(7):1006. doi: 10.3390/biom12071006 
• Borgolte M, Quint I, Kaiser L, Csuk R, Deigner H-P. A fluorescence-based competitive antibody binding assay for kynurenine, a potential biomarker of kidney transplant failure. Diagnostics (Basel). 2022 Jun 2;12(6):1380. doi: 10.3390/diagnostics12061380 
• Borgolte M, Riester O, Quint I, Blendinger F, Bucher V, Laufer S, Csuk R, Scotti L, Deigner H-P. Synthesis of a biocompatible benzophenone-substituted chitosan hydrogel as novel coating for PEEK with extraordinary strong antibacterial and anti-biofilm properties. Materials today chemistry 26 (2022), 101176. doi: 10.1016/j.mtchem.2022.101176 
• Dienelt A, Keller K C, Zur Nieden N. High glucose impairs osteogenic differentiation of embryonic stem cells via early diversion of beta‐catenin from Forkhead box O to T cell factor interaction. Birth Defects Res. 2022 Oct 1;114(16):1056-1074. doi: 10.1002/bdr2.2085. Epub 2022 Sep 26 
• Donnadieu E , Luu M, Alb M, Anliker B, Arcangeli S, Bonini C, De Angelis B, Choudhary R, Espie D, Galy A, Holland C, Ivics Z, Kantari-Mimoun C, Kersten M J, Koehl U, Kuhn C, Laugel B, Locatelli F, Marchiq I, Markman J, Moresco M A, Morris E, Negre H, Quintarelli C, Rade M, Reiche K, Renner M, Ruggiero E, Sanges C, Stauss H, Themeli M, Van den Brulle J, Hudecek M, Casucci M. Time to evolve: predicting engineered T cell-associated toxicity with next-generation models. J Immunother Cancer. 2022 May;10(5):e003486. doi: 10.1136/jitc-2021-003486
• Doß S, Blessing C, Haller K, Richter G, Sauer M. Influence of antibiotics on functionality and viability of liver cells in vitro. Curr Issues Mol Biol. 2022 Oct 3;44(10):4639-4657. doi: 10.3390/cimb44100317 
• Elbalasy I, Wilharm N, Herchenhahn E, Konieczny R, Mayr S G, Schnauß J. From strain stiffening to softening - rheological characterization of keratins 8 and 18 networks crosslinked via electron irradiation. Polymers (Basel). 2022 Feb 4;14(3):614. doi: 10.3390/polym14030614 
• Finkensieper J, Issmail L, Fertey J, Rockstroh A, Schopf S, Standfest B, Thoma M, Grunwald T, Ulbert S. Low-energy electron irradiation of tick-borne encephalitis virus provides a protective inactivated vaccine. Front Immunol. 2022 Mar 7;13:825702. doi: 10.3389/fimmu.2022.825702. eCollection 2022 
• Friedrich M, Aigner A. Therapeutic siRNA: state-of-the-art and future perspectives. BioDrugs. 2022 Sep;36(5):549-571. doi: 10.1007/s40259-022-00549-3. Epub 2022 Aug 23 
• Friedrich M, Pfeifer G, Binder S, Aigner A, Barbosa P V, Makert G R, Fertey J, Ulbert S, Bodem J, Koenig E-M, Geiger N, Schambach A, Schilling E, Buschmann T, Hauschildt S, Koehl U, Sewald K. Selection and validation of siRNAs preventing uptake and replication of SARS-CoV-2. Front Bioeng Biotechnol. 2022 Mar 2;10:801870. doi: 10.3389/fbioe.2022.801870. eCollection 2022 
• Fueldner C, Riemschneider S, Haupt J, Jungnickel H, Schulze F, Zoldan K, Esser C, Hauschildt S, Knauer J, Luch A, Kalkhof S, Lehmann J. Aryl hydrocarbon receptor activation by Benzo[a]pyrene prevents development of septic shock and fatal outcome in a mouse model of systemic Salmonella enterica infection. Cells. 2022 Feb 20;11(4):737. doi: 10.3390/cells11040737 
• Furesi G, Jesus Domingues A M, Alexopoulou D, Dahl A, Hackl M, Schmidt J, Kalkhof S, Kurth T, Taipaleenmaeki H, Conrad S, Hofbauer C, Rauner M, Hofbauer L C. Exosomal miRNAs from prostate cancer impair osteoblast function in mice. Int J Mol Sci. 2022 Jan 24;23(3):1285. doi: 10.3390/ijms23031285 
• Glienke W, Dragon A C, Zimmermann K, Martyniszyn-Eiben A, Mertens M, Abken H, Rossig C, Altvater B, Aleksandrova K, Arseniev L, Kloth C, Stamopoulou A, Moritz T, Lode H N, Siebert N, Blasczyk R, Goudeva L, Schambach A, Koehl U, Eiz-Vesper B, Esser R. GMP-compliant manufacturing of TRUCKs: CAR T cells targeting GD2 and releasing inducible IL-18. Front Immunol. 2022 Mar 24;13:839783. doi: 10.3389/fimmu.2022.839783. eCollection 2022 
• Gnoth K, Geissler S, Feldhaus J, Taudte N, Ilse V, Zürner S, Greiser S, Braumann U-D, Rahfeld J-U, Cynis H, Schilling S. Evidence for enhanced efficacy of passive immunotherapy against beta-amyloid in CD33-negative 5xFAD mice. Biomolecules. 2022 Mar 4;12(3):399. doi: 10.3390/biom12030399 
• Gringmuth M, Walther J, Greiser S, Toussaint M, Schwalm B, Kool M, Kortmann R-D, Glasow A, Patties I. Enhanced survival of high-risk medulloblastoma-bearing mice after multimodal treatment with radiotherapy, decitabine, and abacavir. Int J Mol Sci. 2022 Mar 30;23(7):3815. doi: 10.3390/ijms23073815 
• Groß R, Lívia Mesquita D L, Issmail L, Uhlig N, Eberlein V, Conzelmann C, Olari L-R, Rauch L, Lawrenz J, Weil T, Mueller J A, Cardoso M B, Gilg A, Larrson O, Hoeglund U, Axberg Pålsson, Tvilum A S, Løvschall K B, Kristensen M M, Spetz A-L, Hontonnou F, Galloux M, Zelikin A N, Grunwald T, Muench J. Macromolecular viral entry inhibitors as broad‐spectrum first‐line antivirals with activity against SARS‐CoV‐2. Adv Sci (Weinh). 2022 Jul;9(20):e2201378. doi: 10.1002/advs.202201378. Epub 2022 May 11 
• Guedan S, Luu M, Ammar D, Barbao P, Bonini C, Bousso P, Buchholz C J, Casucci M, De Angelis B, Donnadieu E, Espie D, Greco B, Groen R, Huppa J B, Kantari-Mimoun C, Laugel B, Mantock M, Markman J, Morris E, Quintarelli C, Rade M, Reiche K, Rodriguez-Garcia A, Rodriguez-Madoz J R, Ruggiero E, Themeli M, Hudecek M, Marchig I. Time 2EVOLVE: predicting efficacy of engineered T-cells - how far is the bench from the bedside? J Immunother Cancer. 2022 May;10(5):e003487. doi: 10.1136/jitc-2021-003487 
• Haehnel S, Rade M, Kaiser N, Reiche K, Horn A, Loeffler D, Blumert C, Rapp F, Horn F, Meixensberger J, Renner C, Mueller W, Gaunitz F, Bechmann I, Winter K. RNA sequencing of glioblastoma tissue slice cultures reveals the effects of treatment at the transcriptional level. FEBS Open Bio. 2022 Feb;12(2):480-493. doi: 10.1002/2211-5463.13353. Epub 2021 Dec 29 
• Haendler T, Tutmarc C, Freitag J S, Smith D M, Schnauß J. Constraint release for reptating filaments in semiflexible networks depends on background fluctuations. Polymers (Basel). 2022 Feb 12;14(4):707. doi: 10.3390/polym14040707 
• Hayden PJ, Roddie C, Bader P, Basak GW, Bonig H, Bonini C, Chabannon C, Ciceri F, Corbacioglu S, Ellard R, Sanchez-Guijo F, Jäger U, Hildebrandt M, Hudecek M, Kersten MJ, Köhl U, Kuball J, Mielke S, Mohty M, Murray J, Nagler A, Rees J, Rioufol C, Saccardi R, Snowden JA, Styczynski J, Subklewe M, Thieblemont C, Topp M, Ispizua ÁU, Chen D, Vrhovac R, Gribben JG, Kröger N, Einsele H, Yakoub-Agha I. Management of adults and children receiving CAR T-cell therapy: 2021 best practice recommendations of the European Society for Blood and Marrow Transplantation (EBMT) and the Joint Accreditation Committee of ISCT and EBMT (JACIE) and the European Haematology Association (EHA). Ann Oncol. 2022 Mar;33(3):259-275. doi: 10.1016/j.annonc.2021.12.003. Epub 2021 Dec 16
• Heggli I, Blache U, Herger N, Mengis T, Jaeger PK, Schupbach R, Farshad-Amacker N, Brunner F, Snedeker JG, Farshad M, Distler O, Dudlis S. FGF2 overrides key pro-fibrotic features of bone marrow stromal cells isolated from Modic type 1 change patients. Eur Cell Mater. 2022 Oct 18;44:101-114. doi: 10.22203/eCM.v044a07 
• Hoen L, Rudisch C, Wick M, Indenbirken M, Grundhoff A, Wegwitz F, Kalkhof S, Hildebrand J. Osmotic stress interferes with DNA damage response and H2AX phosphorylation in human keratinocytes. Cells. 2022 Mar 11;11(6):959. doi: 10.3390/cells11060959 
• Hofrichter J, Sempert K, Kerkhoff C, Breitrueck A, Wasserkort R, Mitzner S. Phosphate restriction using a processed clay mineral reduces vascular pathologies and microalbuminuria in rats with chronic renal failure. BMC Nephrol. 2022 Apr 28;23(1):162. doi: 10.1186/s12882-022-02743-5 
• Hunger R, Seliger B, Ogino S, Mantke R. Mortality factors in pancreatic surgery: A systematic review. How important is the hospital volume? Int J Surg. 2022 May;101:106640. doi: 10.1016/j.ijsu.2022.106640. Epub 2022 May 4 
• Ilse V, Scholz R, Wermann M, Naumann M, Staege M S, Roßner S, Cynis H. Immunogenicity of the envelope surface unit of human endogenous retrovirus K18 in mice. Int J Mol Sci. 2022 Jul 28;23(15):8330. doi: 10.3390/ijms23158330 
• Issmail L, Möser C, Jäger C, Altattan B, Ramsbeck D, Kleinschmidt M, Buchholz M, Smith D, Grunwald T. Prefusion-specific antibody-derived peptides trivalently presented on DNA-nanoscaffolds as an innovative strategy against RSV entry. Frontiers in Virology (2022). doi: 10.3389/fviro.2022.994843
• Itani M I, Oberbach A, Salimian K J, Enderle M, Hahn H, Abbarh S, Kendrick K, Schlichting N, Anders R A, Besharati S, Farha J, Fayad L, Kalloo A N, Badurdeen D, Kumbhari V. Gastric mucosal devitalization (GMD): using the porcine model to develop a novel endoscopic bariatric approach. Obes Surg. 2022 Feb;32(2):381-390. doi: 10.1007/s11695-021-05773-4. Epub 2021 Nov 19 
• Jasinski-Bergner S, Bluemke J, Bauer M, Skiebe S L, Mandelboim O, Wickenhauser C, Seliger B. Novel approach to identify putative Epstein–Barr–virus microRNAs regulating host cell genes with relevance in tumor biology and immunology. Oncoimmunology. 2022 May 1;11(1):2070338. doi: 10.1080/2162402X.2022.2070338. eCollection 2022 
• Jasinski-Bergner S, Eckstein M, Taubert H, Wach S, Fiebig C, Strick R, Hartmann A, Seliger B. The human leukocyte antigen G as an immune escape mechanism and novel therapeutic target in urological tumors. Front Immunol. 2022 Feb 3;13:811200. doi: 10.3389/fimmu.2022.811200. eCollection 2022 
• Jasinski-Bergner S, Schmiedel D, Mandelboim O, Seliger B. Role of HLA-G in viral infections. Front Immunol. 2022 Feb 14;13:826074. doi: 10.3389/fimmu.2022.826074. eCollection 2022 
• Jiao Z, Han Y, Zhao J, Chao Z, Tárnok A, You Z. Rapid switching and durable on-chip spark-cavitation-bubble cell sorter. Microsyst Nanoeng. 2022 May 18;8:52. doi: 10.1038/s41378-022-00382-2. eCollection 2022 
• Kaniowska D, Wenk K, Rademacher P, Weiss R, Fabian C, Schulz I, Guthardt M, Lange F, Greiser S, Schmidt M, Braumann U-D, Emmrich F, Koehl U, Jaimes Y. Extracellular Vesicles of Mesenchymal Stromal Cells Can be Taken Up by Microglial Cells and Partially Prevent the Stimulation Induced by β-amyloid Stem Cell. Rev Rep. 2022 Mar;18(3):1113-1126. doi: 10.1007/s12015-021-10261-4. Epub 2022 Jan 26 
• Klinkmann G, Wild T, Heskamp B, Doss F, Doss S, Arseniev L, Aleksandrova K, Sauer M, Reuter D A, Mitzner S, Altrichter J. Extracorporeal immune cell therapy of sepsis: ex vivo results. Intensive Care Med Exp. 2022 Jun 16;10(1):26. doi: 10.1186/s40635-022-00453-8 
• Klose J, Griehl C, Roßner S, Schilling S. Natural products from plants and algae for treatment of Alzheimer’s disease: a review. Biomolecules. 2022 May 12;12(5):694. doi: 10.3390/biom12050694 
• Kruse M, Altattan B, Laux E-M, Grasse N, Heinig L, Moeser C, Smith D M, Hoelzel R. Characterization of binding interactions of SARS-CoV-2 spike protein and DNA-peptide nanostructures. Sci Rep. 2022 Jul 27;12(1):12828. doi: 10.1038/s41598-022-16914-9 
• Kruse M, Moeser C, Smith D M, Mueller-Landau H, Rant U, Hoelzel R, Bier F F. Measuring Influenza A virus and peptide interaction using electrically controllable DNA nanolevers. Advanced materials technologies 7 (2022), 5, 2101141, 11 Seiten. doi: 10.1002/admt.202101141 
• Leptihn S, Loh B W-C. Complexity, challenges and costs of implementing phage therapy. Future Microbiol. 2022 Jun;17:643-646. doi: 10.2217/fmb-2022-0054. Epub 2022 Apr 11 
• Liu M, Tian Y, Zaki H E M, Ahmed T, Yao R, Yan C, Leptihnm S, Loh B, Shahid M S, Wang F, Chen J, Li B. Phage resistance reduced the pathogenicity of Xanthomonas oryzae pv. oryzae on rice. Viruses. 2022 Aug 13;14(8):1770. doi: 10.3390/v14081770 
• Liu Y, Wang S, Schubert M-L, Lauk A, Yao H, Blank M F, Cui C, Janssen M, Schmidt C, Göllner S, Kleist C, Zhou F, Rahfeld J-U, Sauer T, Schmitt M, Mueller-Tidow C. CD33-directed immunotherapy with third-generation chimericantigen receptor T cells and gemtuzumab ozogamicin in intactand CD33-edited acute myeloid leukemia and hematopoieticstem and progenitor cells. Int J Cancer. 2022 Apr 1;150(7):1141-1155. doi: 10.1002/ijc.33865. Epub 2021 Nov 23 
• Loeffler-Wirth H, Kreuz M, Schmidt M, Ott G, Siebert R, Binder H. Classifying germinal center derived lymphomas - navigate a complex transcriptional landscape. Cancers (Basel). 2022 Jul 14;14(14):3434. doi: 10.3390/cancers14143434 
• Loeffler-Wirth H, Rade M, Arakelyan A, Kreuz M, Loeffler M, Koehl U, Reiche K, Binder H. Transcriptional states of CAR-T infusion relate to neurotoxicity - lessons from high-resolution single-cell SOM expression portraying. Front Immunol. 2022 Sep 28;13:994885. doi: 10.3389/fimmu.2022.994885. eCollection 2022 
• Manohar P, Loganathan A, Nachimuthu R, Loh B, Ma L, Turner D, Leptihn S. Complete Genome Sequence of Pseudomonas Phage Motto. Microbiol Resour Announc. 2022 Nov 17;11(11):e0074022. doi: 10.1128/mra.00740-22. Epub 2022 Oct 12 
• Massa C, Seliger B. Enhanced function of vaccine dendritic cells from obese donors upon inhibition of the lipid metabolism. Clin Transl Med. 2022 Feb;12(2):e557. doi: 10.1002/ctm2.557 
• Nachimuthu R, Manohar P, Eniyan K, Archana L, Athira S, Loh B, Ma L, Leptihn S. A lysozyme murein hydrolase with broad-spectrum antibacterial activity from Enterobacter phage myPSH1140. Antimicrob Agents Chemother. 2022 Sep 20;66(9):e0050622. doi: 10.1128/aac.00506-22. Epub 2022 Aug 11 
• Nagel M, Moretti R, Paschke R, Bergen M, Meiler J, Kalkhof S. Integrative model of the FSH receptor reveals the structural role of the flexible hinge region. Structure. 2022 Oct 6;30(10):1424-1431.e3. doi: 10.1016/j.str.2022.07.007. Epub 2022 Aug 15 
• Nickel O, Rockstroh A, Borte S, Wolf J. Evaluation of simple lateral flow immunoassays for detection of SARS-CoV-2 neutralizing antibodies. Vaccines (Basel). 2022 Feb 23;10(3):347. doi: 10.3390/vaccines10030347 
• Nickel O, Rockstroh A, Wolf J, Landgraf S, Kalbitz S, Kellner N, Borte M, Pietsch C, Fertey J, Lübbert C, Ulbert S, Borte S. Evaluation of the systemic and mucosal immune response induced by COVID-19 and the BNT162b2 mRNA vaccine for SARS-CoV-2. PLoS One. 2022 Oct 18;17(10):e0263861. doi: 10.1371/journal.pone.0263861. eCollection 2022 
• Oberbach A, Schlichting N, Hagl C, Lehmann S, Kullnick Y, Friedrich M, Köhl U, Horn F, Kumbhari V, Löffler B, Schmidt F, Joskowiak D, Born F, Saha S, Bagaev E. Four decades of experience of prosthetic valve endocarditis reflect a high variety of diverse pathogens. Cardiovasc Res. 2022 Apr 14;cvac055. doi: 10.1093/cvr/cvac055. Online ahead of print 
• Peter A S, Roth E, Schulz S R, Fraedrich K, Steinmetz T, Damm D, Hauke M, Richel E, Mueller-Schmucker S, Habenicht K, Eberlein V, Issmail L, Uhlig N, Dolles S, Gruener E, Peterhoff D, Ciesek S, Hoffmann M H, Poehlmann S, McKay P F, Shattock R J, Woelfel R, Socher E, Wagner R, Eichler J, Sticht H, Schuh W, Neipel F, Ensser A, Mielenz D, Tenbusch M, Winkler T H, Grunwald T, Überla K, Jäck H-M. A pair of noncompeting neutralizing human monoclonal antibodies protecting from disease in a SARS-CoV-2 infection model. Eur J Immunol. 2022 May;52(5):770-783. doi: 10.1002/eji.202149374. Epub 2021 Sep 13 
• Poh P S, Lingner T, Kalkhof S, Maerdian S, Baumbach J, Dondl P, Duda G N, Checa S. Enabling technologies towards personalization of scaffolds for large bone defect regeneration. Curr Opin Biotechnol. 2022 Apr;74:263-270. doi: 10.1016/j.copbio.2021.12.002. Epub 2022 Jan 7 
• Ramírez Caballero L, Treudler R,Delaroque N, Simon J C, Kern K, Szardenings M. Peptide epitopes as biomarkers of soya sensitization in rBet v 1 immunotherapy of birch‐related soya allergy. Clin Exp Allergy. 2022 Sep 14. doi: 10.1111/cea.14224. Online ahead of print 
• Reiber M, Koska I, Pace C, Schoenhoff K, Schumann L von, Palme R, Potschka H. Development of behavioral patterns in young C57BL/6J mice: a home cage-based study. Sci Rep. 2022 Feb 15;12(1):2550. doi: 10.1038/s41598-022-06395-1 
• Richter A, Seidel R W, Goddard R, Eckhardt T, Lehmann C, Doerner J, Siersleben F, Sondermann T, Mann L, Patzer M, Jaeger C, Reiling N, Imming P. BTZ-derived benzisothiazolinones with in vitro activity against mycobacterium tuberculosis. ACS Med Chem Lett. 2022 Jul 25;13(8):1302-1310. doi: 10.1021/acsmedchemlett.2c00215. eCollection 2022 Aug 11 
• Riester O, Burkhardtsmaier P, Gurung Y, Laufer S, Deigner H-P, Schmidt M S. Synergy of R-(-)carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation. Sci Rep. 2022 Oct 26;12(1):18019. doi: 10.1038/s41598-022-22807-8 
• Ritter P, Cai A, Reischl B, Fiedler M, Prols G, Fries B, Kretzschmar E, Michael M, Hartmann K, Lesko C, Salti H, Arkudas A, Horch R, Paulsen F, Friedrich O, Haug M. MyoBio: an automated bioreactor system technology for standardized perfusion-decellularization of whole skeletal muscle. IEEE Trans Biomed Eng. 2022 Jul;69(7):2305-2313. doi: 10.1109/TBME.2022.3142317. Epub 2022 Jun 17 
• Ruppel K, Fricke S, Koehl U, Schmiedel D. Taking lessons from CAR-T cells and going beyond: tailoring design and signaling for CAR-NK cells in cancer therapy. Front Immunol. 2022 Mar 18;13:822298. doi: 10.3389/fimmu.2022.822298. eCollection 2022 
• Saha S, Ali A, Schnackenburg P, Horke K M, Oberbach A, Schlichting N, Sadoni S, Rizas K, Braun D, Luehr M, Bagaev E, Hagl C, Joskowiak D. Surgery for aortic prosthetic valve endocarditis in the transcatheter era. J Clin Med. 2022 Jun 14;11(12):3418. doi: 10.3390/jcm11123418 
• Saliba F, Bañaras R, Larsen F S, Wilmer A, Parés A, Mitzner S, Stange J, Fuhrmann V, Gilg S, Hassanein T, Samuel D, Torner J, Jaber S. Artificial liver support in patients with liver failure: a modified DELPHI consensus of international experts. Intensive Care Med. 2022 Oct;48(10):1352-1367. doi: 10.1007/s00134-022-06802-1. Epub 2022 Sep 6 
• Schaffert A, Karkossa I, Ueberham E, Schlichting R, Walter K, Arnold J, Blüher M, Heiker J T, Lehmann J, Wabitsch M, Escher B I, Bergen M, Schubert K. Di-(2-ethylhexyl) phthalate substitutes accelerate human adipogenesis through PPARγ activation and cause oxidative stress and impaired metabolic homeostasis in mature adipocytes. Environ Int. 2022 Jun;164:107279. doi: 10.1016/j.envint.2022.107279. Epub 2022 May 6 
• Schary W, Paskali F, Rentschler S, Ruppert C, Wagner G E, Steinmetz I, Deigner H-P, Kohl M. Open-source, adaptable, all-in-one smartphone-based system for quantitative analysis of point-of-care diagnostics. Diagnostics (Basel). 2022 Feb 25;12(3):589. doi: 10.3390/diagnostics12030589 
• Schilling E, Pfeiffer L, Hauschildt S, Koehl U, Claus C. CD14 Is involved in the Interferon response of human macrophages to Rubella virus infection. Biomedicines. 2022 Jan 26;10(2):266. doi: 10.3390/biomedicines10020266 
• Seliger B, Al-Samadi A, Yang B, Salo T, Wickenhauser C. In vitro models as tools for screening treatment options of head and neck cancer. Front Med (Lausanne). 2022 Sep 7;9:971726. doi: 10.3389/fmed.2022.971726. eCollection 2022 
• Seliger B, Jasinski-Bergner S, Massa C, Mueller A, Biehl K, Yang B, Bachmann M, Jonigk D, Eichhorn P, Hartmann A, Wickenhauser C, Bauer M. Induction of pulmonary HLA-G expression by SARS-CoV-2 infection. Cell Mol Life Sci. 2022 Nov 5;79(11):582. doi: 10.1007/s00018-022-04592-9 
• Seliger B, Koehl U. Underlying mechanisms of evasion from NK cells as rationale for improvement of NK cell-based immunotherapies. Front Immunol. 2022 Aug 12;13:910595. doi: 10.3389/fimmu.2022.910595. eCollection 2022 
• Seliger B, Massa C. Modulation of lymphocyte functions in the microenvironment by tumor oncogenic pathways. Front Immunol. 2022 May 19;13:883639. doi: 10.3389/fimmu.2022.883639. eCollection 2022 
• Semwala R, Semwal R B, Lehmann J, Semwal D K. Recent advances in immunotoxicity and its impact on human health: causative agents, effects and existing treatments. Int Immunopharmacol. 2022 Jul;108:108859. doi: 10.1016/j.intimp.2022.108859. Epub 2022 May 19 
• Spukti F F, Schnauß J. Large and stable: actin aster networks formed via entropic forces. Front Chem. 2022 Aug 25;10:899478. doi: 10.3389/fchem.2022.899478. eCollection 2022 
• Stegmann K M, Dickmanns A, Heinen N, Blaurock C, Karrasch T, Breithaupt A, Klopffleisch R, Uhlig N, Eberlein V, Issmail L, Herrmann S T, Schreieck A, Peelen E, Kohlhof H, Sadeghi B, Riek A, Speakman J R, Groß U, Goerlich D, Vitt D, Mueller T, Grunwald T, Pfaender S, Balkema-Buschmann A, Dobbelstein M. Inhibitors of dihydroorotate dehydrogenase cooperate with molnupiravir and N4-hydroxycytidine to suppress SARS-CoV-2 replication. iScience. 2022 May 20;25(5):104293. doi: 10.1016/j.isci.2022.104293. Epub 2022 Apr 25 
• Strobelt R, Adler J, Paran N, Yahalom-Ronen Y, Melamed S, Politi B, Shulman Z, Schmiedel D, Shaul Y. Imatinib inhibits SARS-CoV-2 infection by an off-target-mechanism. Sci Rep. 2022 Apr 6;12(1):5758. doi: 10.1038/s41598-022-09664-1 
• Subbarayan K, Massa C, Leisz S, Steven A, Bethmann D, Biehl K, Wickenhauser C, Seliger B. Biglycan as a potential regulator of tumorgenicity and immunogenicity in K-RAS-transformed cells. Oncoimmunology. 2022 Apr 28;11(1):2069214. doi: 10.1080/2162402X.2022.2069214. eCollection 2022 
• Subirana M A, Riemschneider S, Hause G, Dobritzsch D, Schaumloeffel D, Herzberg M. High spatial resolution imaging of subcellular macro and trace element distribution during phagocytosis. Metallomics. 2022 Apr 1;14(4):mfac011. doi: 10.1093/mtomcs/mfac011 
• Taha A, Bobi J, Dammers R, Dijkhuizen R M, Dreyer A Y, Es A C G M, Ferrara F, Gounis M J, Nitzsche B, Platt S, Stoffel M H, Volovici V, Zoppo G J, Duncker D J, Dippel D W J, Boltze J, Beusekom H M M. Comparison of large animal models for acute ischemic stroke: which model to use? Stroke. 2022 Apr;53(4):1411-1422. doi: 10.1161/STROKEAHA.121.036050. Epub 2022 Feb 15 
• Toma G, Karapetian E, Massa C, Quandt D, Seliger B. Characterization of the effect of histone deacetylation inhibitors on CD8+ T cells in the context of aging. J Transl Med. 2022 Nov 22;20(1):539. doi: 10.1186/s12967-022-03733-9 
• Toma G, Lemnian IM, Karapetian E, Grosse I, Seliger B. Transcriptional Analysis of Total CD8+ T Cells and CD8+CD45RA- Memory T Cells From Young and Old Healthy Blood Donors. Front Immunol. 2022 Jan 27;13:806906. doi: 10.3389/fimmu.2022.806906. eCollection 2022 
• Wagner D L, Koehl U, Chmielewski M, Scheid C, Stripecke R. Review: sustainable clinical development of CAR-T cells - switching from viral transduction towards CRISPR-Cas gene editing. Front Immunol. 2022 Jun 17;13:865424. doi: 10.3389/fimmu.2022.865424. eCollection 2022 
• Weil T, Kirupakaran A, Le M-H, Rebmann P, Mieres-Perez J, Issmail L, Conzelmann C, Mueller J A, Rauch L, Gilg A, Wettstein L, Groß R, Read C, Bergner T, Axberg Pålsson S, Uhlig N, Eberlein V, Woell H, Klaerner F-G, Stenger S, Kuemmerer B M, Streeck H, Fois G, Frick M, Braubach P, Spetz A-L, Grunwald T, Shorter J, Sanchez-Garcia E, Schrader T, Muench J. Advanced molecular tweezers with lipid anchors against SARS-CoV-2 and other respiratory viruses. JACS Au. 2022 Sep 6;2(9):2187-2202. doi: 10.1021/jacsau.2c00220. eCollection 2022 Sep 26 
• Werner M, Dyas A, Parfentev I, Schmidt G E, Mieczkowska I K, Mueller-Kirschbaum L C, Mueller C, Kalkhof S, Reinhardt O, Urlaub H, Alves F, Gallwas J, Prokakis E, Wegwitz F. ROBO3s: a novel ROBO3 short isoform promoting breast cancer aggressiveness. Cell Death Dis. 2022 Sep 3;13(9):762. doi: 10.1038/s41419-022-05197-7 
• Zhang L, Wang X, Hua X, Yu Y, Lepthin S, Loh B. Therapeutic evaluation of the Acinetobacter baumannii phage Phab24 for clinical use. Virus Res. 2022 Oct 15;320:198889. doi: 10.1016/j.virusres.2022.198889. Epub 2022 Aug 12

• Becker R, Goerner C, Reichman P, Dissmeyer N. Trichome transcripts as efficiency control for synthetic biology and molecular farming. Plant synthetic biology (2022), S. 265-276 10.1007/978-1-0716-1791-5_15 
• Fertey J, Standfest B, Beckmann J, Thoma M, Grunwald T, Ulbert S. Low-energy electron irradiation (LEEI) for the generation of inactivated bacterial vaccines. Bacterial vaccines (2022), Seite 97-113, doi: 10.1007/978-1-0716-1900-1_7 

• Del Zotto G, Tárnok A. New years's note 2022 (editorial). Cytometry Part A 101 (2022), 2, Seite 108, doi: 10.1002/cyto.a.24532
• Graf A, Schönfelder J, Scholles M. MEMS-based gas analysis for future medical diagnostics. IVAM-Magazin »inno«, Volume 27, No. 83, November 2022, S. 1-2 
• Reinig P, Dallmann H-G, Schwarzenberg M, Ziebarth J, Knobbe J, Junek J, Rudolf Herbst, Julian Rathert, Rüdiger Gerlach, Ulrich Blache, Tretbar S, Fricke S. MEMS-based confocal laser scanning fluorescence microscopy for tumor demarcation in oncological surgery. SPIE Proceedings Volume 11949, Advanced Biomedical and Clinical Diagnostic and Surgical Guidance Systems XX; 1194906 (2022). doi: 10.1117/12.2608547 
  
• Schönfelder J, Kuhlmeier D. Erkennung antibiotikaresistenter Bakterien über die Atemluft. Management & Krankenhaus, Ausgabe 3/2022, Seite 31
• Storch C, Hoffmann A, Sauer F, Dreyer A, Janzekovic J, Kuerek H, Greiser S, Günther RO, Braumann UD, Kiefer I, Kohl S, Koehler C, Daehne M, Kauffold J, Sigmarsson H, Schmiedeknecht G, Alexandrova V, Kebbel K, Lucarotti S, Khani N, Desai A, Wiggenhauser PS, Champ S, Chhaya MP, Hutmacher DW, Lehmann J. Präklinische Langzeitstudie zur Evaluierung der Wirksamkeit und Sicherheit eines neuartigen Brustimplantats im Großtiermodell Göttinger Minischwein. Rackwitz R, Truyen U (Hrsg): LBH: 11. Leipziger Tierärztekongress – Tagungsband 1. Leipzig, 2022. S. 578-581
• Su X, Tárnok A. A mini review of recent development of flow cytometry in China (editorial). Cytometry Part A 101 (2022), 8, Seite 614-616, doi: 10.1002/cyto.a.24671 
  
• Tárnok A. Many shades of sorting (editorial). Cytometry Part A 101 (2022), 4, Seite 280-281, doi: 10.1002/cyto.a.24548
  
• Tárnok A. CYTO reloaded (editorial). Cytometry Part A 101 (2022), 7, Seite 546, doi: 10.1002/cyto.a.24666

• Alb M, Einsele H, Loskill P, van der Meer A, Sewald K, Reiche K, Köhl U, Hudecek M on behalf of the imSAVAR consortium. Novel strategies to enhance the safety of CAR T cell immunotherapy: The imSAVAR project. Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 7.–10.10.2022, Wien, Österreich 
• Alb M, Einsele H, Loskill P, van der Meer A, Sewald K, Reiche K, Köhl U, Hudecek M on behalf of the imSAVAR consortium. Novel strategies to enhance the safety of CAR T cell immunotherapy: The imSAVAR project. 2nd Translational Research Conference: Immune & Cellular Therapies: Focus on Advanced Gene-Engineered Immune Cells, 12.–14.9.2022, Berlin 
• Alb M, Einsele H, Loskill P, van der Meer A, Sewald K, Reiche K, Köhl U, Hudecek M on behalf of the imSAVAR consortium. Novel strategies to enhance the safety of CAR T cell immunotherapy: The imSAVAR project. ISCT 2022 San Francisco Annual Meeting, 4.–7.5.2022, San Francisco, USA 
• Allelein S, Aerchlimann K, Freese C, Kuhlmeier D. Automated and specific immunomagnetic isolation of prostate-derived EVs from urine. Inaugural Virtual Symposium on Urinary Extracellular Vesicles uEV 2022, 15.–16.2.2022, online 
• Balche U. Immunotherapy. Cell and Gene Therapy/LNP Workshop, 30.11.2022, Leipzig 
• Beneke V, Grieger K, Hartwig C, Sohn K, Blaudszun AR, Hilger N, Sewald K, Braun A, Hesse C. Differential microbial compositions in the gut influence the immune response in ex vivo intestinal tissue slices. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Summer School 2022, 7.–10.6.2022, Berlin
• Beneke V, Grieger K, Hartwig C, Sohn K, Blaudszun AR, Hilger N, Sewald K, Braun A, Hesse C. From gut to lung: Microbiota dependent modulation of relevant mediators in intestinal tissue slices ex vivo. Fraunhofer ITEM Satelliten-Workshop »Alternatives to Animal Testing«, 22.6.2022, Hannover 
• Beneke V, Grieger K, Hartwig C, Sohn K, Blaudszun AR, Hilger N, Sewald K, Braun A, Hesse C. Microbiota dependent modulation of immune mediators in intestinal tissue slices ex vivo. 23rd European Congress on Alternatives to Animal Testing (EUSAAT), 26.–28.9.2022, Linz, Österreich 
• Blaudszun AR. CAR T cell ATMPs. REANIMA Konsortium-Meeting, 7.–8.6.2022, Madrid, Spanien 
• Ciulean SI, Fischer J, Possardt E, Koehl U, Grunwald T. Establishment of a 3D head and neck cancer cell culture model for the assessment of NK cell based therapies. 19th Meeting of the Society for Natural Immunity (SNI), 14.–17.5.2022, Bonita-Springs, Florida, USA 
• Duenkel A. CAR-NK 4.0 progress report. SaxoCell Konsortiumsmeeting, 20.6.2022, Dresden 
• Eberlein V, Ahrends M, Bayer L, Finkensieper J, Mansuroglu Y, Standfest B, Beckmann J, Lange F, Wronski S, Schopf S, Dressman J, Thoma M, Hesse C, Ulbert S, Grunwald T. Protective efficacy of an inactivated whole virus RSV vaccine in mice. 12th International RSV Symposium, 29.9.–2.10.2022, Belfast, Vereinigtes Königreich 
• Eberlein V, Ahrends M, Bayer L, Finkensieper J, Mansuroglu Y, Standfest B, Beckmann J, Lange F, Wronski S, Schopf S, Dressman J, Thoma M, Hesse C, Ulbert S, Grunwald T. Protective efficacy of an inactivated whole virus RSV vaccine in mice. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Tag der Immunforschung, 27.9.2022, Frankfurt/Main
• Eberlein V, Ahrends M, Bayer L, Finkensieper J, Mansuroglu Y, Standfest B, Beckmann J, Lange F, Wronski S, Schopf S, Dressman J, Thoma M, Hesse C, Ulbert S, Grunwald T. Protective efficacy of an inactivated whole virus RSV vaccine in mice. 31st Annual Meeting of the Society for Virology, 30.3.–2.4.2022, München 
• Eberlein V, Ahrends M, Bayer L, Finkensieper J, Mansuroglu Y, Standfest B, Beckmann J, Lange F, Wronski S, Schopf S, Dressman J, Thoma M, Hesse C, Ulbert S, Grunwald T. Protective efficacy of an inactivated whole virus RSV vaccine in mice. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Summer School 2022, 7.–10.6.2022, Berlin
• Fabian C, Greiser S. HITCHHIKER‘S GUIDE TO THE CELL - Employing viral and bacterial targeting sequences for live cell imaging. Forum Experiment der Volkswagen Stiftung, 19.–20.05.2022, Hannover 
• Fertey J. Low-energy electron irradiation efficiently inactivates pathogens in liquids and is a promising method for the generation of vaccines. 16th Vaccine Congress, 12.–14.9.2022, Riva del Garda, Italien 
• Finkensieper J. Irradiation of zoonotic apicomplexan parasites with low energy electrons for the development of vaccine candidates. Zoonoses 2022 - International Symposium on Zoonoses Research, 5.–7.10.2022, Berlin 
• Finkensieper J. Irradiation of zoonotic parasites with low energy electrons for the development of vaccine candidates. International Congresses of Parasitology – ICOPA XV, ICOPAnhagen, 21.–26.8.2022, Kopenhagen, Dänemark 
• Finkensieper J. Low-energy electron irradiation of tick-borne encephalitis virus provides a protective inactivated vaccine. 31st Annual Meeting of the Society for Virology, 30.3.–2.4.2022, München 
• Fricke S. B- und T-Zell- Immunreaktionen nach Virusinfektionen bzw. nach Vakzination am Beispiel SARS-COV2. Weiterbildungsveranstaltung NIO Sachsen e. V. für onkologische Fachkräfte, 25.6.2022, Chemnitz 
• Fricke S. Next Generation GMP Prozessentwicklung von ATMPs für Herz- und Nierenerkrankungen. 5. Kardiorenaler Forschungsdialog, 6.–7.5.2022, Berlin 
• Fricke S. Prävention der GvHD mit Erhalt des GvL Effektes durch den anti-CD4 Antikörper Palixizumab®. MSGO Frühjahrskolloquiuum, 29.4.2022, Leipzig 
• Fricke S. Verbundprojekt SaxoCell – Präzisionstherapie-Cluster für Sachsen. Onkologie im Dialog, 24.9.2022, Lichtenstein 
• Gjurova B, Schultz C, Kuhlmeier D, Lipp T, Schoenfelder J. Identification of Covid-19 marker in exhaled breath by the use of ion mobility spectrometry. Breath Biopsy Conference 2022, 1.–2.11.2022, online 
• Kaempf C, Kreuz M, Scholz A, Rade M, Loeffler D, Blumert C, Reiche K. Software Development Processes for Diagnostics in Precision Medicine. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Tag der Immunforschung, 27.9.2022, Frankfurt/Main
• Kitte R, Fricke S, Koehl U, Tretbar S. Transient expression of a CD123-directed chimeric antigen receptor for safe immunotherapy of acute myeloid leukemia. 4th International Conference on Lymphocyte Engineering ICLE, 31.3.–2.4.2022, München 
• Kitte R, Rabel M, Fricke S, Köhl U, Tretbar S. Lipid Nanoparticles as Next-Generation mRNA Delivery System for Transient CAR T Cell Therapy. 10th mRNA Health Conference, 8.–10.11.2022, Boston, USA / online 
• Kitte R, Rabel M, Fricke S, Köhl U, Tretbar S. Lipid Nanoparticles as Next-Generation mRNA Delivery System for Transient CAR T Cell Therapy. Leipzig Immune ONcology (LION) Conference 2022, 22.–23.11.2022, online 
• Kitte R. Development of mRNA-based CAR T Cell Therapies: Benefits and Challenges. Cell and Gene Therapy / LNP Workshop, 30.11.2022, Leipzig 
• Kitte R. Transient Expression of mRNA-LNP-based Chimeric Antigen Receptors for Safe Immunotherapy. Precision NanoSystems TeaTime Webinar, 24.8.2022, online 
• Koch F. OPTIX Project progress report. SaxoCell Konsortiumsmeeting, 20.6.2022, Dresden 
• Köhl U. Alternative cell therapies. (Vortrag) ESMO Congress 2022, 9.–13.9.2022, Paris, Frankreich
• Köhl U. CAR NK cells: pushing the boundaries in cancer treatment. (Vortrag) MI3-Kick-Off-Symposium, 29.9.2022, Mannheim 
• Köhl U. CAR T and CAR NK cells: pushing the boundaries in cancer treatment. (Vortrag) 14th ÖGMBT Annula Meeting, 19.–22.9.2022, Wien, Österreich 
• Köhl U. CAR T-Zellen Herstellung/externe Produktion. (Vortrag) DGHO CAR T-cell-Workshop, 4.3.2022, Berlin 
• Köhl U. CAR-T-Zellen: Herausforderungen und Perspektiven für Herstellung und Logistik. (Vortrag) Paul-Martini-Workshop 2022 »Zellbasierte Therapien – Stand und Ausblick«, 6.4.2022, Berlin / online 
• Köhl U. Cell therapeutics for immune-mediated diseases. (Vortrag) Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Tag der Immunforschung, 27.9.2022, Frankfurt/Main
• Köhl U. Chimeric antigen receptors (CAR) expressing T cells and NK cells: pushing the boundaries in cancer treatment. (Vortrag) Lady Mary Montagu lecture series der Deutschen Gesellschaft für Immunologie e.V., 27.4.2022, online 
• Köhl U. Deutschlands Beitrag zur Klinischen Forschung in der Welt – Forschungskultur und politischer Gestaltungswille. (Vortrag) Frankfurter Forum »Forschungsförderung in der Medizin«, 29.10.2022, Fulda 
  
• Köhl U. Die Zukunft der CAR-T-Therapie: Neue Konzepte. (Vortrag) Essener Forum Zelluläre Therapien, 19.8.2022, Essen 
  
• Köhl U. Einführung NK and CAR-NK. (Vortrag) MATURE-NK Winter School, 14.–16.3.2022, online 
• Köhl U. From CAR T to off the shelf CAR NK cells for tumor retargeting. (Vortrag) Tumor Immunology Meets Oncology (TIMO) XVI 2022 Halle, 7.–9.7.2022, Halle (Saale) 
• Köhl U. Gene Editing und Zelltherapieschwerpunkt im UCCL. (Vortrag) UCCL-Mitgliederversammlung, 28.2.2022, online 
  
• Köhl U. Immunologische Aspekte der Gentherapie. (Vortrag) Forum Gentherapie »Gentherapien bei seltenen Erkrankungen – Diagnosestelltung und Erfolgsfaktoren«, 17.9.2022, Berlin 
  
• Köhl U. Looking beyond T-cells: NK cells as effectors of tumour control. (Vortrag) ESMO Targeted Anticancer Therapies Congress (TAT), 7.–8.3.2022, online 
  
• Köhl U. Manufacturing and quality control of CAR effector cells. (Vortrag) 29th Annual Meeting of the European Society of Gene & Cell Therapy – ESGCT 2022, 11.–14.10.2022, Edinburgh, Vereinigtes Königreich 
• Köhl U. Modern cell therapy manufacturing techniques. (Vortrag) UCCL goes international Singapur Symposium, 23.4.2022, online 
• Köhl U. Möglichkeiten und klinischer Einsatz der Zelltherapie. (Vortrag) 5. Kardiorenaler Forschungsdialog, 6.–7.5.2022, Berlin 
• Köhl U. Network for cell and gene therapy in cross linking between university and non university partners along the whole value chain. (Vortrag) ATMP-GMP Community Event, 17.11.2022, Berlin 
• Köhl U. Neue Horizonte in der Immuno-Oncology und im Cell-Engineering. (Vortrag) 38. Wissenschaftliche Jahrestagung der DGPP, 29.9.–2.10.2022, Leipzig 
• Köhl U. Neue Therapiemethoden. (Vortrag) Ausschuss Forschung, Wissenschaft und Bildung des VCI, 10.3.2022, online 
• Köhl U. Non-canonical CRISPR RNAs derived from host transcripts enable multiplexable RNA diagnostics. (Vortrag) 3rd FORUM Science & Health: New impulses for the Medicine of the Future, 5.–6.7.2022, Fürstenfeldbruck 
  
• Köhl U. SaxoCell. (Vortrag) Erfahrungsaustausch der Zukunftscluster der ersten Wettbewerbsrunde »Clusters4Future«, 31.5.2022, Berlin 
  
• Köhl U. Vector Production: Critical starting material for CAR effector cells. (Vortrag) EBMT, CTIWP-Workshop »2nd workshop on European academic CART clinical trials«, 14.1.2022, online 
• Köhl U. Vectors vs. cells what is the product?: Cell Product. (Vortrag) 4th European CAR T-cell Meeting, 10.–12.2.22, online 
• Köhl U. Zell- und Gentherapie. (Vortrag) Rotary Club Leipzig, 28.4.2022, Leipzig 
• Köhl U. Zelluläre Immuntherapie: Von CAR-T- zu CAR-NK-Zellen in AML und MDS. (Vortrag) Jahrestagung der Deutschen, Österreichischen und Schweizerischen Gesellschaften für Hämatologie und Medizinische Onkologie, 7.–10.10.2022, Wien, Österreich 
  
• Köhl U. Zukunft der CAR-Therapien. (Vortrag) Krebsmedizin aktuell: CAR-T-Zell-Therapie, 16.3.2022, online 
• Koeppen J, Schulze A, Machner L, Wermann M, Eichentopf R, Guthardt M, Kriegeskorte M, Hartlage-Ruebsamen M, Morawski M, von Hoersten S, Demuth HU, Roßner S, Schilling S. Amyloid-β peptides induce aggregation of α-synuclein in vitro. Neuro4D Conference 2022, 16.–17.5.2022, Mainz 
• Kreuz M, Rade M, Fuessel S, Blumert C, Borkowetz A, Löffler D, Otto D, Woeller L.A, Schimmelpfennig C, Hönscheid P, Sommer U, Baretton G.B, Wirth M, Thomas C, Horn F, Reiche K. A prognostic gene-expression signature for FFPE-biopsies of prostate cancer. 74. Kongress der Deutschen Gesellschaft für Urologie, 21.–24.9.2022, Hamburg 
  
• Lehmann J. Phytochemicals as potential therapeutics in inflammatory bowel disease. (Invited speaker) International conference on conservation, cultivation and sustainable use of high altitude medicinal and aromatic plants for the socioeconomic development, funded by National Medicinal Plants Board (Ministry of AYUSH, Govt. of India), 7.–8.5.2022, Rishikul, Haridwar, Uttarakhand, Indien 
• Loeffler D, Greiser S, Rade M, Reiche K, Blumert C. Spatial Transcriptomes as Readouts for Next-Generation Cancer Models. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Tag der Immunforschung, 27.9.2022, Frankfurt/Main
• Loeffler D, Große FP, Greiser S, Rade M, Reiche K, Blumert C. Spatial Transcriptomes from fresh frozen and FFPE tissues as Readouts for Next-Generation Cancer Models. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Tag der Immunforschung, 27.9.2022, Frankfurt/Main
• Luu M, Sanges C, Courcault E, Pennings E, Casucci M, Franz P, Donnadieu E, Quintarelli C, Guedan S, Morris E, Ivics Z, Jaeger U, Busch D, Girvalaki C, Paiva B, Richter A, Markman J, Cabrerizo Y, Ammar D, Junius S, Guillevic Y, Reimer T, Hoen N, Draper A, Sheth S, Wagers S, Negre H, Hudecek M. T2EVOLVE - Accelerating development and improving access to CAR- and TCR-engineered T cell therapy in Europe. 4th International Conference on Lymphocyte Engineering ICLE, 31.3.–2.4.2022, München 
• Luu M, Sanges C, Courcault E, Pennings E, Casucci M, Franz P, Donnadieu E, Quintarelli C, Guedan S, Morris E, Ivics Z, Jaeger U, Busch D, Girvalaki C, Paiva B, Richter A, Markman J, Cabrerizo Y, Ammar D, Junius S, Guillevic Y, Reimer T, Hoen N, Draper A, Sheth S, Wagers S, Negre H, Hudecek M. T2EVOLVE - Standardization of pre-clinical and clinical development of engineered T cell therapy in Europe; a cross functional multistakeholder initiative. EBMT-EHA 4th European CAR T-cell Meeting, 10.–12.2.2022, online 
• Mueller C, Lehmann J. In vitro validation of Glypican-1 as a novel potential target for antibody- or CAR-based therapies of triple-negative breast cancer (TNBC). Joint Meeting of the German Society of Immunology (DGfI) and the Austrian Society for Allergology & Immunology (ÖGAI), 7.–10.9.2022, Hannover 
• Mueller C, Lehmann J. In vitro validation of Glypican-1 as a novel potential target for antibody- or CAR-based therapies of triple-negative breast cancer (TNBC). Leipzig Immune ONcology (LION) Conference 2022, 22.–23.11.2022, online 
• Mueller C, Lehmann J. In vitro validation of Glypican-1 as a novel potential target for antibody- or CAR-based therapies of triple-negative breast cancer (TNBC). Tumor Immunology Meets Oncology (TIMO) XVI 2022 Halle, 7.–9.7.2022, Halle (Saale) 
• Mueller C. Identification of therapeutic targets against triple-negative breast cancer. 2nd Summer Workshop Cancer Center Central Germany, 23.9.2022, Dornburg 
• Nelz SC, Doss S, Schoelzel A, Zschenderlein, Sauer M, Hofrichter J. Translational Evaluation of a Stem Cell-Based Model for Functional Impairments of the Blood-Brain Barrier. Forschungscamp 2022, Universität Rostock, 17.11.2022, Rostock 
• Palm S. CAR-NK 4.0 progress report. 1st SaxoCell Scientific Advisory Board Meeting, 28.10.2022 
• Palm S. SP3 »Translational development of a primary CAR-NK-product for clinical trials: Process scaling and assay development/validation«. TransOnc »NK fit 4 AML« – First In-Person-Meeting, 28.9.2022 
• Przybylski-Wartner S, Müller C, Lehmann J. Generation of a platform for the development of therapeutic monoclonal antibodies. 7th Halle Conference on Recombinant Proteins, 13.–14.10.2022, Halle (Saale) 
• Rade M, Loeffler D, Große FP, Scholz A, Blumert C, Reiche K, Kunz M. Spatial Transcriptomics of primary melanoma lesions. 48. ADF-Tagung, 23.–26.2.2022, online 
• Schaffert A, Karkossa I, Ueberham E, Schlichting R, Walter K, Arnold J, Blüher M, Heiker JT, Lehmann J, Wabitsch M, Escher BI, Bergen MvB, Schubert K. Proteomics reveals mechanisms of metabolic disruptive effects of emerging di-(2-ethylhexyl) phthalate substitutes. 23rd European Congress on Alternatives to Animal Testing (EUSAAT), 26.–28.9.2022, Linz, Österreich 
• Schenk M, Rahfeld JU, Blaudszun AR, Linnert M, Stubbs MT. Antibody 5G4 with high reactivity for disease-associated aSyn shows promising characteristics as a therapeutic for Parkinson's disease. 7th European Crystallographic School, 10.–15.7.2022, Lissabon, Portugal 
• Schmidt JR, Wiltzsch V, Dias B, Sofia D, Adamowicz K, Lio CT, Arend L, Lehmann J, Lingner T, Tsoy O, Laske T, Poh PSP, Baumbach J, Kalkhof S. Longitudinal screening of the plasma proteome to identify biomarkers for reduced bone healing capacities in patients comorbid with type 2 diabetes mellitus. e:Med Meeting 2022 on Systems Medicine, 28.–30.11.2022, Heidelberg 
• Schoenfelder J, Gjurova B, Schultz C, Bangen LM, Steppert I, Kuhlmeier D. In-vitro Differenzierung verschiedener Bakterien sowie antibiotikaresistenter E. coli-Stämme mittels Ionenmobilitätsspektrometrie als Basis für POC-Anwendungen. 5. Münchner Point-of-Care Testing Symposium, 27.–29.9.2022, München 
• Schoenfelder J, Schultz C, Gjurova B, Bangen LM, Kuhlmeier D. In-vitro Differenzierung antibiotikaresistenter und -sensitiver E. coli- und S. aureus-Stämme mittels Ionenmobilitätsspektrometrie. IMS 2022 - Anwender*innentreffen Ionenmobilitätspektrometrie Unna, 15.–17.3.2022, Unna 
• Serfling R, Kitte R, Martin C, Fricke S, Köhl U, Tretbar S. Generation of mRNA-based Chimeric Antigen Receptor (CAR) T Cell Therapy. 10th International mRNA Health Conference, 8.–10.11.2022, Boston, USA 
• Smith D. Enhancement of bioactive molecules with DNA-templated oligovalence. (Vortrag) Leibniz Institut für Polymerforschung, 22.11.2022 
• Storch C, Hoffmann A, Sauer F, Dreyer A, Janzekovic J, Kuerek H, Greiser S, Guenther RO, Braumann UD, Kiefer I, Kohl S, Koehler C, Dähne M, Kauffold J, Sigmarsson H, Schmiedeknecht G, Alexandrova V, Kebbel K, Lucarotti S, Khani N, Desai A, Wiggenhauser PS, Champ S, Chhaya MP, Hutmacher DW, Lehmann J. Präklinische Langzeitstudie zur Evaluierung der Wirksamkeit und Sicherheit eines neuartigen Brustimplantats im Großtiermodell Göttinger Minischwein. 11. Leipziger Tierärztekongress, Workshop »Translationale Tierexperimentelle Forschung«, 7.–9.7.2022, Leipzig 
• Szardenings M, Delaroque N, Fischer M, Kern K, Puder M, Ramirez Caballero L, Wehrmann D, Ehrentreich-Foerster E. Personalized immune analyses: Epitope mapping of the immunome. Fraunhofer Cluster of Excellence Immune-Mediated Diseases CIMD, Tag der Immunforschung, 27.9.2022, Frankfurt/Main
• Szardenings M, Delaroque N, Fischer M, Kern K, Puder M,Ramirez Caballero L, Wehrmann D, Ehrentreich-Foerster E. Personalized immune analyses: Epitope mapping of the immunome. Symposium on regulatory autoantibodies targeting G protein-coupled receptors (GPCRs), 15.–16.9.2022, Lübeck 
• Tretbar S, Blache U, Blaudszun AR, Duenkel A, Franz P, Schmiedel D, Koehl U, Fricke S. Bridging the gap-ATMP process development accelerating from bench-to bed-side. International Conference on Lymphocyte Engineering 2022, 31.3.–2.4.2022, München 
• Tretbar S. Basics in Immunology. Cell and Gene Therapy / LNP Workshop, 30.11.2022, Leipzig 
• Tretbar S. Development and Potential of mRNA-based Cell and Gene Therapies. HS Coburg Kolloquium, 7.12.2022, online 
• Tretbar S. Immunologische Grundlagen der Zelltherapie. CIMD 4D Workshop »Zell- und Gentherapien – von den Grundlagen bis zur Anwendung«, 9.5.2022, online 
• Tretbar S. Immuntherapie am Fraunhofer IZI. Konrad-Adenauer-Stiftung Kolloquium, 10.2.2022, online 
• Tretbar S. SaxoCell OPTIX Project Presentation. BIO-Europe, 24.–26.10.2022, Leipzig 
• Tretbar S. Status Quo of T cell Therapies. Cell and Gene Therapy/LNP Workshop, 30.11.2022, Leipzig 
• Tretbar S. Transient Expression of mRNA-LNP-based Chimeric Antigen Receptors for Safe Immunotherapy. CGTI Tea Time Webinar, 6.7.2022, online 
• Uhlig N, Issmail L, Donner AK, Rockstroh A, Ulbert S, Grunwald T. Mouse models for neurotropic Flavivirus infections. 31st Annual Meeting of the Society for Virology, 30.3.–2.4.2022, München 
• Ulbert S. Low energy irradiation for the generation of inactivated human and veterinary vaccines. World Vaccine Congress Europe 2022, 11.–14.10.2022, Barcelona, Spanien 
• Wagner AI, Zuerner S, Smith D, Komban R, Janschel M, Gimmler C, Blaudszun AR, Greiser S. Development of a diagnostic tool to increase the accuracy in diagnosing malignant melanoma. Vernetzungstreffen der Projekte aus dem 1. Fördercall des Fraunhofer-Zentrums für digitale Diagnostik, 6.12.2022, Leipzig