Inflammation and Tumor Models

The Inflammation and Tumor Models Unit provides the scientific expertise for the preclinical testing of inflammatory diseases, tumor diseases and humanized mouse models. The focus here is placed on developing, evaluating, validating and utilizing tailored in vitro and in vivo models.
 

Our focus areas

In vitro analyses

• Immunodiagnostics / immunotoxicological investigations
• Flow cytometry analyses / imaging flow cytometry
• Real-time cell analysis (invasion assay, proliferation assay, migration)
• Immunohistochemical analyses

In vitro models

• In vitro model for the intestinal epithelial barrier (GLP-like / GLP)
• In vitro models for investigating new targets against tumor antigens

In vivo models

• DSS-induced colitis (GLP / non-GLP)
• Infection models (GLP-like / GLP)
• Preclinical testing of a CAR-T cell therapy in the NSG mouse model
• Humanized mouse models
  • with a xenotransplanted immune system (through CD34 hematopoietic stem cells or PBMCs) (GLP / non-GLP)
  • with xenotransplanted tumor tissue (CDX / PDX)
• Developing fully human monoclonal antibodies and identifying new therapeutic target structures in the humanized mouse tumor model
• Antibody development