Department of Preclinical Development and Validation

ResearchGate
https://www.researchgate.net/profile/Joerg-Lehmann

LinkedIn
www.linkedin.com/in/jörg-lehmann-88274420

ORCID
https://orcid.org/0000-0001-8560-648X

Loop profile
84446

Scopus Author ID
55702479400

1989 
University of Leipzig, Leipzig, Germany
Diploma in Biology (equivalent to M.Sc.)
B-cell stimulation, immunotoxins

1994
Fraunhofer Institute for Toxicology and Aerosol Research, Hannover and University of Leipzig, Leipzig, Germany
Dr. rer. nat. (Ph.D.)
T-cell regulation in Leishmania donovani infection (Th1/Th2)

2004
German Society of Immunology (DGfI), Lübeck
Fachimmunologe DGfI (Consultant Immunologist, German Society of Immunology, DGfI)
Immunity to infection (Th1/Th2),  Immunotoxicology /  Immunopharmacology,  Experimental Rheumatology, Monoclonal Antibodies

• Immunity to Salmonella enterica
• Arylhydrocarbon receptor research – Immunotoxicology and therapy development
• Chronic inflammatory bowel disease – models and therapy development
• Immune oncology – models and development of therapeutic antibodies
• Development of GLP-conform testing strategies for ATMPs, medical devices and combined ATMPs

1989
Arno Wetzel Award for best Diploma Thesis, University of Leipzig

1990-1993
Fraunhofer Institute for Toxicology and Aerosol Research ITA, Hannover / University of Leipzig, PhD student (Supervisors: Prof. Dr. Marie-Luise Lohmann-Matthes, Fraunhofer ITA; Prof. Dr. Karl Drößler, University of Leipzig)

1994-1996
University of Leipzig, Medical Faculty, Institute for Clinical Immunology and Transfusion Medicine (Head: Prof. Dr. Frank Emmrich), Postdoc

1995
University of Texas, Southwestern Medical School of Dallas, Cancer Immunobiology Center, TX, USA, Research visit, Postdoctoral work with Prof. Dr. Nancy Street

1996-2001
University of Leipzig, Faculty of Veterinary Medicine, Institute of Immunology (Head: Prof. Dr. Gottfried Alber), Scientific Assistant/Assistant Lecturer in Veterinary Immunology

2001
University of Cambridge, UK, Research visit, Collaboration with Dr. Pietro Mastroeni and Dr. Duncan Maskell

2001-2005
Labor Diagnostik GmbH Leipzig (SME) / Priontype GmbH&Co. KG (SME), Leipzig, Head of Research & Development / Dept. Immunology

2003
Northern Ireland Government, Dept. of Agriculture and Rural Development, Research visit, Collaboration with Dr. Alastair Douglas

2006-date
Fraunhofer Institute for Cell Therapy and Immunology IZI, Leipzig,

2006-2015
Head of Cell Engineering/GLP unit

2009-2015
Deputy Head of Department Cell Engineering

2008-date
Head of GLP test facility

2016-2021
Head of Department Therapy Validation

2016-2017
Head of Manufacturing GMP Therapeutic Antibodies

2017-2019
Deputy Head of Manufacturing GMP Therapeutic Antibodies

2019-2020
Head of Manufacturing GMP Biopharmaceuticals

2021-date
Head of Department Preclinical Development and Validation

2009-date
Assistant Lecturer in Immunology for Pharmacists, University of Leipzig, Faculty of Biological Sciences, Pharmacy, and Psychology; since 2018: Medical Faculty

2012-date
Assistant Lecturer in Good Laboratory Practice, post-gradual M.Sc. program „Clinical research and translational medicine“, University of Leipzig, Medical Faculty

2018-date
Assistant Lecturer in Immunotoxicology, post-gradual M.Sc. program „Toxikologie und Umweltschutz“ / Modul „Immuntoxikologie “, University of Leipzig, Medical Faculty

• Deutsche Gesellschaft für Immunologie e.V., DGfI
• Gesellschaft für Versuchstierkunde e.V. Society of Laboratory Animal Science, GV-SOLAS
• Deutsche Gesellschaft für Toxikologie e.V. (GT)
• Deutsche Gesellschaft für experimentelle und klinische Pharmakologie und Toxikologie (DGPT)
• German QP Association

• Lehmann J, Emmrich F, Sack U. Autonomously growing, invasive fibroblast-derived cell line. EP-Patent, Pat.-Nr. 00 11 1698.7-2116
• Engemann C, Hoeschler K, Lehmann J, Gabert J. Procedure for enrichment and detection of variant prion proteins (PrP^Sc). German Patent, Pat.-Nr. 102 30 141.7
• Engemann C, Hoeschler K, Lehmann J, Gabert J, Krummrei U. Procedure for enrichment and detection of pathological altered prion proteins (PrP^Sc). PCT-Patent, PCT/DE03/02249
• Engemann C, Krummrei U, Lehmann J. Procedure for preparation of body fluids as a prerequisite for detection of pathological altered prion proteins (PrP^Sc). German Patent, Pat.-Nr. 103 54 207.8
• Lehmann J, Zoldan K. Verfahren und Vorrichtung zur Überwachung des Gesundheitszustands von Milchkühen. German Patent-Anmeldung, Pat.-Nr. F30787DE; PCT-Anmeldung, PCT F30787WO; Internationale Anmeldung PCT/EP2016/063109, WO 2016/198501 A1
• Ueberham E, Havenith H, Spiegel H, Schillberg S, Lehmann J. Means and methods for detecting soy allergens. German Patent application, Pat.-Nr. 10 2018 217 447.4, PCT-Anmeldung/EP2019/077598

Researchgate
www.researchgate.net/profile/Stefan-Kalkhof

LinkedIn
www.linkedin.com/in/stefan-kalkhof-017440146

ORCID
Stefan Kalkhof (0000-0001-6121-7105) - ORCID

ResearcherID
F-7932-2013

Scopus Author ID
6506708985

GND
143885871

Loop profile
1208906

SciProfiles
1132584

2004
University of Leipzig, Leipzig, Germany
Diploma in Chemistry (equivalent to M.Sc.)
Protein-Ligand Interaction with Ion Cyclotron Resonance Mass Spectrometry

2004-2008
University of Halle, Halle, Germany / Vanderbilt University, Nashville, USA
Dr. rer. nat. (Ph.D.)
Investigation of the Laminin self-interaction by chemical cross-linking, mass spectrometry, and computational modelling

• Development and application of LC-MS based proteomics techniques (protein quantification, protein-protein-interaction, protein-small molecule interaction, PTMs)
• Testing and optimization of biomaterials for clinical application (cell interaction, drug release, biodegradation)
• Elucidation of disease mechanism and drug response (wound healing, kidney diseases)

Since 2021
Deputy Head of the Department of Preclinical Development and Validation, Fraunhofer IZI, Leipzig

Since 2021
Spokesman of the research priority program of the HAW Coburg, “Analyzing and Promoting Health”

Since 2017
Director of the Institute for Bioanalytics, HAW Coburg, https://bioanalytik.co/

Since 2016
Research Professor for Instrumental Bioanalytics, HAW Coburg, www.hs-coburg.de/Kalkhof

Since 2016
Head of the Fraunhofer Unit “Proteomics”, Fraunhofer IZI

Since 2015
Professor for Instrumental Bioanalysis, Faculty of Applied Natural Sciences and Health, HAW Coburg

2010
"Science Award" of Bayer Bitterfeld GmbH

2008-2016
Head of the research group "Mass Spectrometry", Department of Proteomics, Helmholtz Centre for Environmental Research – UFZ Leipzig

2004-2008
PhD thesis at the Chair of Pharmaceutical Chemistry, Institute of Pharmacy, Martin Luther University Halle-Wittenberg, Supervisor: Prof. Dr. Andrea Sinz

2006
Research stay at Vanderbilt University, Center for Structural Biology, Nashville, USA, Research Group Prof. Dr. Jens Meiler

2004
Diploma thesis in the junior research group "Protein-Ligand Interaction with Ion Cyclotron Resonance Mass Spectrometry" at the Faculty of Biochemistry, University of Leipzig

2002/5-7
Research stay, project “investigation of drug encapsulation using secondary ion mass spectrometry”, University of Antwerp, Belgium, research group Prof. Dr. L. van Vaeck

2002/2-5
Internship, Bayer AG, Central Research, Leverkusen

• Gesellschaft Deutscher Chemiker eV
• German Society for Mass Spectrometry DGMS
• American Society for Mass Spectrometry
• Tissue Engineering and Regenerative Medicine International Society
• Society of Environmental Toxicology and Chemistry

2023 
Fraunhofer Institute of Cell Therapy and Immunology and University of Leipzig, Leipzig, Germany
Dr. rer. nat.
Immunomodulating effects of aryl hydrocarbon receptor ligands

2012
Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Biology - Master of Science
Effects of benzo(a)pyrene on activation process of murine macrophages

2010
Martin-Luther-University Halle-Wittenberg, Halle (Saale), Germany
Biology - Bachelor of Science 
Molecular basics of cadmium and formaldehyde detoxification in E. coli 

• Study director for GLP-compliant studies for different test items like ATMPs
• Arylhydrocarbon receptor research – Immunotoxicology and therapy development
• Chronic inflammatory bowel disease – models and therapy development

2021 – date
Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Head of Toxicology and Immunotoxicology Unit

2019–2021
Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Head of Preclinical Models Unit

2017–2019
Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Deputy Head of Preclinical Models Unit

2018 – date
Assistant Lecturer in preclinical models, post-gradual M.Sc. program "Clinical research and translational medicine", University of Leipzig, Medical Faculty

2018–2019
Assistant Lecturer in Immunotoxicology, post-gradual M.Sc. program "Toxikologie und Umweltschutz" / Modul "Immuntoxikologie", University of Leipzig, Medical Faculty

2017 – date
Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Study director of the GLP test facility

2013–2023
Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Department of Preclinical Development and Validation, PhD program

• German Society for Immunology

2012 
University of Leipzig, Faculty of Veterinary Medicine, Institute of Anatomy, Histology and Embryology
Specialist in Veterinary Anatomy
Theoretical and practical training to become a specialist in Veterinary Anatomy

2001 
University of Leipzig, Faculty of Veterinary Medicine, Institute of Anatomy, Histology and Embryology
Dr. med. vet. (DVM)
Neuroanatomical research, immunohistochemical methods, light and electron microscopy

1997 
Free University of Berlin, Berlin, Germany
Veterinarian
Curriculum of Veterinary Medicine

• Conducting the pathohistologic study phase of preclinical studies to demonstrate safety and efficacy or to exclude immunotoxicologic effects under GLP conditions in short- and long-term studies
• Pathohistologic studies on systemic and local side effects of various test items such as biodegradable polycaprolactone scaffolds, therapeutic HBV vaccines, ATMPs, drug-coupled nanoparticles
• Routine staining and immunohistochemical studies
• Toxicopathological section evaluations and quantifications using image analysis software programs

2023
Assistant Lecturer in Immunotoxicology, post-gradual M.Sc. program "Toxikologie und Umweltschutz"/ Modul "Immuntoxikologie", University of Leipzig, Medical Faculty

2019 – to date
Assistant Lecturer M.Sc. program "Bioanalytik", Faculty of Applied Natural Sciences and Health at Coburg University of Applied Sciences

2018 – to date
Assistant Lecturer Modul "Biologicals – Von der Entwicklung zur Anwendung", M.Sc. program "Pharmazeutische Biotechnologie", Faculty of Natural and Environmental Sciences, University of Applied Sciences Zittau-Görlitz

2017 – to date
Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig (Head: Prof. Dr. Dr. Ulrike Koehl), Department of Preclinical Development and Validation (Head: Dr. Joerg Lehmann), Deputy Head of Toxicology and Immunotoxicology and Scientific Assistant

2013–2017
Vita 34 AG, Leipzig, Head of the Research and Development group, Referee

2003–2013
University of Leipzig, Faculty of Veterinary Medicine, Institute of Anatomy, Histology and Embryology (Head of Institute of Histology and Embryology: Prof. Dr. Johannes Seeger), Scientific Assistant

2000–2003
GenPat77 Pharmacogenetics AG, Berlin (Head: Prof. Dr. Nalân Utku), Scientific Assistant

2012 
Brandenburg University of Technology (BTU) Cottbus-Senftenberg, University of Applied Sciences, Germany
Biotechnology - Bachelor of Science
Hybrid pig versus Göttingen minipig-derived cartilage and chondrocytes show pig line-dependent differences 

2014 
Charite University Medicine Berlin, Germany
Toxicology - Master of Science
Establishment of an in vitro assay for the detection of cytokine production in activated T cells

• Tumor – models and therapy development
• Humanized immune system mouse model
• Antibody development
• Study director for GLP-compliant studies for ATMPs and combined ATMPs

Since 2015
PhD program at Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig Department of Preclinical Development and Validation

2017 – date
Study director of the GLP test facility

2021 – date
Head of the working group "Inflammation and Tumor Models" at Fraunhofer IZI, Department of Preclinical Development and Validation

2018 – date
Assistant Lecturer in preclinical models, post-gradual M.Sc. program „Clinical research and translational medicine“, University of Leipzig, Medical Faculty

2018 – date
Assistant Lecture in preclinical models, Pharmaceutical Biotechnology Master's Degree, Hochschule Görlitz/Zittau

2015 – 2017
Fraunhofer Career Development Program “Talenta” of Fraunhofer

2017
Publication Award 2017 (Fraunhofer IZI; Science Day)

2012 
Martin-Luther University Halle-Wittenberg, Germany
Diploma in Biochemistry (equivalent to M.Sc.)
Production of proteins, FRET measurements of fluorescent proteins

2020 
University of Leipzig, Leipzig, Germany
Dr. rer. nat (Ph.D.)
Nanoparticle-mediated transfection in immune cells (t cells), gene therapy of immunological diseases

• Therapy development for inflammatory bowel disease (IBD) in vitro and in vivo
• Nanoparticle-mediated transfection
• Study director for GLP-compliant studies for different test items (ATMPs, small molecules)

2013–2015
Scientific employee at Saxonian Incubator for Clinical Translation, University Leipzig

2016–2019
Scientific employee and deputy group leader of the working group "OpTcell", Department Cell Therapy at Fraunhofer IZI, Leipzig

2013–2020
PhD studies in clinical Pharmacology, Medicine faculty, University Leipzig

2019 – date
Deputy group leader of working group "Inflammation and Tumor Models" and study director for GLP-compliant studies at Fraunhofer IZI, Department of Preclinical Development and Validation, Leipzig

Researchgate
www.researchgate.net/profile/Johannes-Schmidt-5

LinkedIn
www.linkedin.com/in/johannes-r-schmidt-5254a325b

ORCID
https://orcid.org/0000-0002-2026-9715

Loop profile
2160074

SciProfiles
2025784

2017 
Helmholtz Centre for Environmental Research – UFZ and University of Leipzig, Leipzig, Germany
Dr. rer. nat.
Molecular effects of GAG-modified scaffolds in bone regeneration

2013 
University of Rostock, Rostock, Germany
Microbiology and Biochemistry - Master of Science
Proteomics methods in the analysis of preclinical samples

2011
University of Rostock, Rostock, Germany
Bio Sciences - Bachelor of Science 
Mass spectrometry-based methods in the quantification of Rituximab in patients plasma 

• Development and testing of functionalized scaffolds for clinical application in bone regeneration
• Method development for proteomics analysis of preclinical and clinical samples 

2019 – date
Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Deputy Head of Proteomics Unit

2017–2019
Helmholtz Centre for Environmental Research (UFZ), Leipzig, Postdoctoral fellow in the Department of Molecular Systems Biology

2013–2017
Helmholtz Centre for Environmental Research (UFZ), Leipzig, PhD candidate in the Department of Proteomics
Department of Preclinical Development and Validation, PhD program

• American Society for Mass Spectrometry (ASMS)

2023 
University of Leipzig, Faculty of Veterinary Medicine, Institute of Physiological Chemistry, Endocrinology
Specialist in laboratory animal science
Theoretical and practical training to become a specialist in laboratory animal science

2022 
University of Leipzig, Faculty of Veterinary Medicine, Institute of Physiological Chemistry, Biochemistry
Dr. med. vet. (DVM)
Equine Hox gene expression profile in cultured nasal and articular chondrocytes

2010 
University of Leipzig, Faculty of Veterinary Medicine
Veterinarian
Curriculum of Veterinary Medicine

• Conducting preclinical study phase to demonstrate safety and efficacy under GLP conditions in short- and long-term studies in large animals

2023 – date
Assistant Lecturer in documentation in animal trials (VetSpA), University of Leipzig, Faculty of Veterinary Medicine

2022 – date
Assistant Lecturer in exotic species, University of Leipzig, Faculty of Veterinary Medicine

2020 – date
Fraunhofer Institute for Cell Therapy and Immunology (IZI), Leipzig, Study director of the GLP test facility

2019–2023
Veterinarian in laboratory animal facility, University of Leipzig, Faculty of Veterinary Medicine

2018 – date
Assistant Lecturer in preclinical models, post-gradual M.Sc. program "Clinical research and translational medicine", University of Leipzig, Medical Faculty

2017 – date
Fraunhofer Institute for Cell Therapy and Immunology IZI Leipzig

2014–2017
Teacher for animal medical assistants and animal care keepers, Sächsische LehmbauGruppe

2010–2014
Veterinarian in different veterinary practices in Leipzig