Ligand Development

protein structure
© Fraunhofer IZI

The unit focuses on the interaction of biomolecules, in particular the identification of peptides for tumor targeting and antibody characterization. A new peptide phage display method is combined with modern devices and measurement methods. This allows in silico data evaluation for epitope mapping as well as the immunome of patient sera (e.g. allergy and vaccine research) and the identification of peptide ligands for the characterization of complex structures (e.g. cell surfaces) as an alternative to antibodies. These applications range from the labeling of cancer cells / tissues to the characterization of (stem) cells in different culture and storage conditions.


Here is an overview of the methods we use.


Here we show you a selection of current projects.


We work closely with partners from science and industry. Find out more here.


Here you will find an overview of all publications that have emerged from the research work of our unit.



Press release / 2.3.2020

Hitchhiker’s Guide to the Cell

Fraunhofer IZI researches to improve imaging methods for organoids

Flyer and presentations



L-Act biological surface modification



Food allergen epitopes and peptide arrays

Allergy to tree nuts



Corona virus epitope arrays

Peptide epitopes covering CoV-2 and endemic corona virus


Cancer targeting peptides: Nanoparticles in tumor treatment

Presentation | 2023

PepTalk 2023: YghJ – Preclinical Vaccination and Human Disease Studies at the Epitope Level

Presentation | 2022

L-Act biological surface modification

Presentation | 2019

Rapid and extensive epitope fingerprinting of mono- and polyclonal antibodies

Presentation | 2018

PepTalk 2018: Variations in vaccine response