Vesicle-based Immunomodulation

© Marcos Ramos Celis

The Vesicle-based Immunomodulation (VBI) Unit focuses on the research field of extracellular vesicles (EVs) and their role as vehicles for intercellular communication. New diagnostic and therapeutic approaches are being developed based on this research.

Extracellular vesicles are shed by nearly every cell type and might later be reabsorbed by other cells. EVs are involved in a number of physiological processes as cell interaction mediators. Their molecular signature marks the starting point for new diagnostic and therapeutic concepts.

The VBI unit has built a solid platform of methods for isolation, engineering and characterization of extracellular vesicles. Special emphasis is placed on assessing the functionality of extracellular vesicles on immune cells under inflammatory conditions. Functional testing is used here to evaluate the effect of the vesicles on T-cells, monocytes and microglial cells.

Our EV expertise

  • Isolating, quantifying and storing extracellular vesicles
  • Analyzing surface molecules on extracellular vesicles
  • Loading of molecules in EVs by cell genetic modification
  • Conducting electron microscopy examinations of human extracellular vesicles
  • Carrying out functional in-vitro and in-vivo tests
 

Projects

Here we show you a selection of current projects.

Publications

Here you will find an overview of all publications that have emerged from the research work of our unit.