Fraunhofer Institute for Cell Therapy and Immunology IZISpecies
Mouse
Fields of application
The Tail Suspension test is the most widely used test correlate for depression. It measures the duration of mobility and immobility that is inferred as an index of behavioural despair (the animal has resigned escaping).
The model can be used for the following fields of application:
- Disease effects on mental health (depression)
- Drug administration
- Therapeutic efficacy
- Proof of concept
Endpoints / outcome parameter
- Measuring of depression
Readout parameter
- Activity / inactivity time [sec]
- Change in amplitude [%]
Quality management and validation
- Controls
- Randomisation
- Blinded data collection and analysis
- Biometric expertise
- Internal quality management