Species
Mouse
Fields of application
The Open Field is a simple tool for measuring locomotor activity and anxiety. Mice are placed into an arena with high walls. They naturally try to avoid brightly lit and open areas and have a tendency to be thigmotaxic. The time the mice stay close to the walls or centre region is measured.
The model can be used for the following fields of application:
- Disease effects on anxiety or locomotor activity
- Drug administration
- Therapeutic efficacy
- Proof of concept
Endpoints / outcome parameter
- Measuring of anxiety-like behaviour
- Locomotor activity
Readout parameter
- Speed [m/sec]
- Distance [cm]
- Time spend in central/peripheral regions [sec or %]
Quality management and validation
- Controls
- Randomisation
- Blinded data collection and analysis
- Biometric expertise
- Internal quality management