Department of Extracorporeal Therapy Systems

Publications

Borgolte M, Quint I, Kaiser L, Csuk R, Deigner H-P. A fluorescence-based competitive antibody binding assay for kynurenine, a potential biomarker of kidney transplant failure. Diagnostics (Basel). 2022 Jun 2;12(6):1380. doi: 10.3390/diagnostics12061380
Borgolte M, Riester O, Quint I, Blendinger F, Bucher V, Laufer S, Csuk R, Scotti L, Deigner H-P. Synthesis of a biocompatible benzophenone-substituted chitosan hydrogel as novel coating for PEEK with extraordinary strong antibacterial and anti-biofilm properties. Materials today chemistry 26 (2022), 101176. doi: 10.1016/j.mtchem.2022.101176
Doß S, Blessing C, Haller K, Richter G, Sauer M. Influence of antibiotics on functionality and viability of liver cells in vitro. Curr Issues Mol Biol. 2022 Oct 3;44(10):4639-4657. doi: 10.3390/cimb44100317
Hofrichter J, Sempert K, Kerkhoff C, Breitrueck A, Wasserkort R, Mitzner S. Phosphate restriction using a processed clay mineral reduces vascular pathologies and microalbuminuria in rats with chronic renal failure. BMC Nephrol. 2022 Apr 28;23(1):162. doi: 10.1186/s12882-022-02743-5
Klinkmann G, Wild T, Heskamp B, Doss F, Doss S, Arseniev L, Aleksandrova K, Sauer M, Reuter D A, Mitzner S, Altrichter J. Extracorporeal immune cell therapy of sepsis: ex vivo results. Intensive Care Med Exp. 2022 Jun 16;10(1):26. doi: 10.1186/s40635-022-00453-8
Riester O, Burkhardtsmaier P, Gurung Y, Laufer S, Deigner H-P, Schmidt M S. Synergy of R-(-)carvone and cyclohexenone-based carbasugar precursors with antibiotics to enhance antibiotic potency and inhibit biofilm formation. Sci Rep. 2022 Oct 26;12(1):18019. doi: 10.1038/s41598-022-22807-8
Ritter P, Cai A, Reischl B, Fiedler M, Prols G, Fries B, Kretzschmar E, Michael M, Hartmann K, Lesko C, Salti H, Arkudas A, Horch R, Paulsen F, Friedrich O, Haug M. MyoBio: an automated bioreactor system technology for standardized perfusion-decellularization of whole skeletal muscle. IEEE Trans Biomed Eng. 2022 Jul;69(7):2305-2313. doi: 10.1109/TBME.2022.3142317. Epub 2022 Jun 17
Saliba F, Bañaras R, Larsen F S, Wilmer A, Parés A, Mitzner S, Stange J, Fuhrmann V, Gilg S, Hassanein T, Samuel D, Torner J, Jaber S. Artificial liver support in patients with liver failure: a modified DELPHI consensus of international experts. Intensive Care Med. 2022 Oct;48(10):1352-1367. doi: 10.1007/s00134-022-06802-1. Epub 2022 Sep 6
Schary W, Paskali F, Rentschler S, Ruppert C, Wagner G E, Steinmetz I, Deigner H-P, Kohl M. Open-source, adaptable, all-in-one smartphone-based system for quantitative analysis of point-of-care diagnostics. Diagnostics (Basel). 2022 Feb 25;12(3):589. doi: 10.3390/diagnostics12030589
Blaess M, Kaiser L, Sommerfeld O, Csuk R, Deigner H-P. Drugs, metabolites, and lung accumulating small lysosomotropic molecules: multiple targeting impedes SARS-CoV-2 infection and progress to COVID-19. Int J Mol Sci. 22 (2021), 4, 1797. doi: 10.3390/ijms22041797
Breitrück A, Weigel M, Hofrichter J, Sempert K, Kerkhoff C, Mohebali N, Mitzner S, Hain T, Kreikemeyer B. Smectite as a preventive oral treatment to reduce clinical symptoms of DSS induced colitis in Balb/c mice. Int J Mol Sci. 22 (2021), 16, 8699. doi: 10.3390/ijms22168699
Gragoll I, Schumann L, Neubauer M, Westphal C, Lang H. Healthcare avoidance: a qualitative study of dental care avoidance in Germany in terms of emergent behaviours and characteristics. BMC Oral Health. 21 (2021), 1, 563. doi: 10.1186/s12903-021-01933-1
Koball S, Westphal C, Frimmel S, Hinz M, Klammt S, Mitzner S. Comparison of changes in albumin binding capacity during hemodiafiltration or hemodialysis with middle cut off membranes. Int J Artif Organs 44 (2021), 5, Seite 297-301. doi: 10.1177/0391398820961780
Körtge A, Majcher-Peszynska J, Heskamp B, Wasserkort R, Mitzner S. Antibiotics removal by continuous venovenous hemofiltration with a novel asymmetric triacetate membrane hemofilter: an in vitro study. Blood Purif. 50 (2021), 6, Seite 899-905. doi: 10.1159/000513417
Krüsemann H, Töllner P, Westphal E, Hofrichter J, Seitz H. Design and 3D printing of miniaturized dialyzers for laboratory use. Transactions AMM 3 (2021), 1, 545. doi: 10.18416/AMMM.2021.2109545
Mahmoud M, Ruppert C, Rentschler S, Laufer S, Deigner H-P. Combining aptamers and antibodies: lateral flow quantification for thrombin and interleukin-6 with smartphone readout. Sensors and actuators. B, chemical 333 (2021), 129246. doi: 10.1016/j.snb.2020.129246
Schätzl T, Kaiser L, Deigner H-P. Facioscapulohumeral muscular dystrophy: genetics, gene activation and downstream signalling with regard to recent therapeutic approaches: an update. Orphanet J Rare Dis. 16 (2021), 1, 129. doi: 10.1186/s13023-021-01760-1
Laur N, Kinscherf R, Pomytkin K, Kaiser L, Knes O, Deigner HP. ICP-MS trace element analysis in serum and whole blood. PLoS ONE 15 (2020) 5, e0233357, 14 Seiten. dx.doi.org/10.1371/journal.pone.0233357
Mohebali N, Ekat K, Kreikemeyer B, Breitrück A. Barrier Protection and Recovery Effects of Gut Commensal Bacteria on Differentiated Intestinal Epithelial Cells In Vitro. Nutrients (2020), 8, 2251. dx.doi.org/10.3390/nu12082251
Blaess M, Deigner HP. Derailed ceramide metabolism in atopic dermatitis (AD): a causal starting point for a personalized (basic) therapy. International journal of molecular sciences 20 (2019), 16, 15 Seiten, dx.doi.org/10.3390/ijms20163967
Frimmel S, Hinz M, Schipper J, Bogdanow S, Mitzner S, Koball S. Cytokine adsorption is a promising tool in the therapy of hemophagocytic lymphohistiocytosis. International Journal of Artificial Organs 42 (2019), 11, Seiten 658-664. dx.doi.org/10.1177/0391398819857444
Mahmoud M, Laufer S, Deigner HP. Visual aptamer-based capillary assay for ethanolamine using magnetic particles and strand displacement. Mikrochimica acta 186 (2019), 11, 8 Seiten, dx.doi.org/10.1007/s00604-019-3795-9
Mahmoud M, Laufer S, Deigner HP. Data for homogeneous thermofluorimetric assays for ethanolamine using aptamers and a PCR instrument. Data in brief 24 (2019), 103946, 11 Seiten, dx.doi.org/10.1016/j.dib.2019.103946
Mahmoud M, Laufer S, Deigner HP. An aptamer based thermofluorimetric assay for ethanolamine. Biochimie 158 (2019), Seite 233-237, dx.doi.org/10.1016/j.biochi.2019.01.014
Ruppert C, Phogat N, Laufer S, Kohl M, Deigner HP. A smartphone readout system for gold nanoparticle-based lateral flow assays: application to monitoring of digoxigenin. Mikrochimica acta 186 (2019), 2,9 Seiten, dx.doi.org/10.1007/s00604-018-3195-6
Koertge A, Wasserkort R, Wild T, Mitzner S. Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Critical Accumulation of Rivaroxaban. Blood Purification 45 (2018), 126–128. dx.doi.org/10.1159/000484923
Koertge A, Wild T, Heskamp B, Folk M, Mitzner S, Wasserkort R. Thrombogenicity and long-term cytokine removal capability of a novel asymmetric triacetate membrane hemofilter. Journal of artificial organs 21 (2018), 4, S. 435-442. dx.doi.org/10.1007/s10047-018-1062-1
Peters F, Westphal C, Kramer A, Westerman R. Is the rise in the prevalence of renal replacement therapy at older ages the price for living longer? Frontiers in Public Health 6 (2018), 138, 7 S. dx.doi.org/10.3389/fpubh.2018.00138
Sauer M, Haubner C, Richter G, Ehler J, Mencke T, Mitzner S, Margraf S, Altrichter J, Doß S, Nöldge-Schomburg G v. Impaired cell viability and functionality of hepatocytes after incubation with septic plasma-results of a second prospective biosensor study. Frontiers in Immunology. 9 (2018), 1448. dx.doi.org/10.3389/fimmu.2018.01448
Sauer M, Richter G, Altrichter J, Wild T, Doß F, Mencke T, Ehler J, Doß S, Koch S, Schubert A, Nöldge-Schomburg G, Mitzner SR. Effects of Bioreactor-Oxygenation During Extracorporeal Granulocytes Treatment in Septic Patients. Therapeutic apheresis and dialysis 22 (2018), 4, S. 389-398. dx.doi.org/10.1111/1744-9987.12657
Schäffler H, Breitrück A. Clostridium difficile - from colonization to infection. Frontiers in Microbiology 9 (2018), 646. dx.doi.org/10.3389/fmicb.2018.00646
Frimmel S, Mitzner SR, Koball S. Immunoadsorption as a Long-Term Therapy in Recurrent Focal Segmental Glomerulosclerosis After Renal Transplantation. Therapeutic apheresis and dialysis. 21 (2017), 1, S. 108-109. dx.doi.org/10.1111/1744-9987.12487
Doß S, Potschka H, Doß F, Mitzner S, Sauer M. Hepatotoxicity of antimycotics used for invasive fungal infections: In vitro results. BioMed research international 2017 (2017), Art. 9658018, 10 S. dx.doi.org/10.1155/2017/9658018
Rekers NV, Bajema IM, Mallat MJ, Petersen B, Anholts JD, Swings GM, van Miert PP, Kerkhoff C, Roth J, Popp D, van Groningen MC, Baeten D, Goemaere N, Kraaij MD, Zandbergen M, Heidt S, van Kooten C, de Fijter JW, Claas FH, Eikmans M. Beneficial immune effects of myeloid-related proteins in kidney transplant rejection. American journal of transplantation. 16 (2016), 5, S. 1441-1455. dx.doi.org/10.1111/ajt.13634
Sauer M, Altrichter J, Haubner C, Pertschy A, Wild T, Doß F, Mencke T, Thomsen M, Ehler J, Henschel J, Doß S, Koch S, Richter G, Nöldge-Schomburg G, Mitzner SR. Bioartificial therapy of sepsis : Changes of norepinephrine-dosage in patients and influence on dynamic and cell based liver tests during extracorporeal treatments. BioMed research international. (2016), Art. 7056492, 11 S. dx.doi.org/10.1155/2016/7056492
Sombetzki M, Koslowski N, Doss S, Loebermann M, Trauner M, Reisinger EC, Sauer M. Biosensor for hepatocellular injury corresponds to experimental scoring of hepatosplenic schistosomiasis in mice. BioMed research international. (2016), Art. 1567254, 7 S. dx.doi.org/10.1155/2016/1567254
Sponholz C, Matthes K, Rupp D, Backaus W, Klammt S, Karailieva D, Bauschke A, Settmacher U, Kohl M, Clemens MG, Mitzner S, Bauer M, Kortgen A. Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure : A prospective, randomised crossover study. Critical care. 20(2016), Art. 2. dx.doi.org/10.1186/s13054-015-1159-3
Ehler J, Koball S, Sauer M, Mitzner S, Hickstein H, Benecke R, Zettl UK. Response to Therapeutic Plasma Exchange as a Rescue Treatment in Clinically Isolated Syndromes and Acute Worsening of Multiple Sclerosis: A Retrospective Analysis of 90 Patients. Plos One 2015 Aug 5;10(8):e0134583. DOI dx.doi.org/10.1371/journal.pone.0134583. eCollection 2015
Maruschke M, Riebold D, Holtfreter MC, Sombetzki M, Mitzner S, Loebermann M, Reisinger EC, Hakenberg OW. Pneumocystis pneumonia (PCP) and Pneumocystis jirovecii carriage in renal transplantation patients: a single-centre experience. Wien Klin Wochenschr. 2014 Dec;126(23-24):762-6.
Frimmel S, Schipper J, Henschel J, Yu TT, Mitzner SR, Koball S. First description of single-pass albumin dialysis combined with cytokine adsorption in fulminant liver failure and hemophagocytic syndrome resulting from generalized herpes simplex virus 1 infection. Liver Transpl. 2014 Dec;20(12):1523-4.
Klammt S, Mitzner SR, Reisinger EC, Stange J. No sustained impact of intermittent extracorporeal liver support on thrombocyte time course in a randomized controlled albumin dialysis trial. Ther Apher Dial. 2014 Oct;18(5):502-8.
Mencke T, Jacobs RM, Machmueller S, Sauer M, Heidecke C, Kallert A, Pau HW, Noeldge-Schomburg G, Ovari A. Intubating conditions and side effects of propofol, remifentanil and sevoflurane compared with propofol, remifentanil and rocuronium: a randomised, prospective, clinical trial. BMC Anesthesiology 2014; DOI dx.doi.org/10.1186/1471-2253-14-39.
Ehler J, Koball S, Sauer M, Hickstein H, Mitzner S, Benecke R, Zettl UK. Therapeutic plasma exchange in glucocorticosteroid-unresponsive patients with Clinically Isolated Syndrome. Therapeutic Apheresis and Dialysis. 2014 Oct;18(5):489-96.DOI dx.doi.org/10.1111/1744-9987.12176
Frimmel S, Schipper J, Henschel J, Yu TT, Mitzner SR, Koball S. First description of single-pass albumin dialysis combined with cytokine adsorption in fulminant liver failure and hemophagocytic syndrome resulting from generalized herpes simplex virus 1 infection. Liver Transplantation. 2014 Dec;20(12):1523-4. DOI dx.doi.org/10.1002/lt.24005
Klammt S, Mitzner SR, Reisinger EC, Stange J. No sustained impact of intermittent extracorporeal liver support on thrombocyte time course in a randomized controlled albumin dialysis trial. Therapeutic Apheresis and Dialysis. 2014 Oct;18(5):502-8. DOI dx.doi.org/10.1111/1744-9987.12124
Breitrück A, Sparmann G, Mitzner S, Kerkhoff C. Establishment of a novel extracorporeal bowel model to study luminal approaches to treat inflammatory bowel disease. Dis Model Mech. 2013; 6:1487-1493. DOI dx.doi.org/10.1242/dmm.011734
Bañares R, Nevens F, Stolze Larsen F, Jalan R, Albillos A, Dollinger M, Saliba F, Sauerbruch T, Klammt S, Ockenga J, Pares A, Wendon J, Brünnler T, Kramer L, Mathurin P, Mata MD, Gasbarrini A, Müllhaupt B, Wilmer A, Laleman W, Eefsen M, Sen S, Zipprich A, Tenorio T, Pavesi M, Schmidt HH, Mitzner S, Williams R, Arroyo V. Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial. Hepatology 57 (2013)3: 1153-1162. DOI dx.doi.org/10.1002/hep.26185
Mitzner S, Gloger M, Henschel J, Koball S. Improvement of hemodynamic and inflammatory parameters by combined hemoadsorption and hemodiafiltration in septic shock: A case report. Blood purification 35 (2013) 4: 314-315. DOI dx.doi.org/10.1159/000351206
Sauer M, Altrichter J, Mencke T, Klöhr S, Thomsen M, Kreutzer HJ, Nöldge-Schomburg G, Mitzner S. Role of different replacement fluids during extracorporeal treatment in a pig model of sepsis. Ther Apher Dial. 17 (2013) 1:84-92. DOI dx.doi.org/10.1111/j.1744-9987.2012.01103.x
Mitzner S. Stellenwert der MARS®-Dialyse beim Acute-on-chronic-Leberversagen: Role of MARS® dialysis in acute-on-chronic liver failure. Z Gastroenterol. 51 (2013) 10: 1193-1194. DOI dx.doi.org/10.1055/s-0033-1350351
Averill MM, Kerkhoff C, Bornfeldt KE. S100A8 and S100A9 in cardiovascular biology and disease. Arterioscler Thromb Vasc Biol. 32 (2012), 2, S. 223-9. DOI dx.doi.org/10.1161/ATVBAHA.111.236927.
Kerkhoff C, Voss A, Scholzen TE, Averill MM, Zänker KS, Bornfeldt KE. Novel insights into the role of S100A8/A9 in skin biology. Exp Dermatol. 21 (2012), 11, S. 822 - 6. DOI dx.doi.org/10.1111/j.1600-0625.2012.01571.x.
Kielstein JT, Beutel G, Fleig S, Steinhoff J, Meyer TN, Hafer C, Kuhlmann U, Bramstedt J, Panzer U, Vischedyk M, Busch V, Ries W, Mitzner S, Mees S, Stracke S, Nürnberger J, Gerke P, Wiesner M, Sucke B, Abu-Tair M, Kribben A, Klause N, Schindler R, Merkel F, Schnatter S, Dorresteijn EM, Samuelsson O, Brunkhorst R; Collaborators of the DGfN STEC-HUS registry. Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome: an analysis of the German STEC-HUS registry. Nephrol Dial Transplant. 27 (2012), 10, S. 3807-15. DOI dx.doi.org/10.1093/ndt/gfs394.
Klammt S, Wojak HJ, Mitzner A, Koball S, Rychly J, Reisinger EC, Mitzner S. Albumin-binding capacity (ABiC) is reduced in patients with chronic kidney disease along with an accumulation of protein-bound uraemic toxins. Nephrol Dial Transplant. 27 (2012), 6, S. 2377-83. DOI dx.doi.org/10.1093/ndt/gfr616.
Klionsky DJ and 1269 others. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8 (2012), 4, S. 445 - 544. DOI dx.doi.org/10.4161/auto.19496.
Maletzki C, Bodammer P, Breitrück A, Kerkhoff C. S100 proteins as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma. Hepat Mon. 2012, 12 (10 HCC):e7240. DOI dx.doi.org/10.5812/hepatmon.7240.
Sauer M, Altrichter J, Mencke T, Klöhr S, Thomsen M, Kreutzer HJ, Nöldge-Schomburg G, Mitzner SR. Plasma separation by centrifugation and subsequent plasma filtration: impact on survival in a pig model of sepsis. Ther Apher Dial. 16 (2012), 3, S. 205-12. DOI dx.doi.org/10.1111/j.1744-9987.2011.01055.x.
Sauer M, Haubner C, Mencke T, Nöldge-Schomburg G, Mitzner S, Altrichter J, Stange J. Impaired cell functions of hepatocytes incubated with plasma of septic patients. Inflamm Res. 61 (2012), 6, S. 609-16. DOI dx.doi.org/10.1007/s00011-012-0451-9.
Voss A, Bode G, Kerkhoff C. Double-stranded RNA induces IL-8 and MCP-1 gene expression via TLR3 in HaCaT-keratinocytes. Inflamm Allergy Drug Targets. 11 (2012), 5, S. 397-405.
Voss A, Gescher K, Hensel A, Nacken W, Zänker KS, Kerkhoff C. Double-stranded RNA induces S100 gene expression by a cycloheximide-sensitive factor. FEBS Lett. 586 (2012), 2, S. 196-203. DOI dx.doi.org/10.1016/j.febslet.2011.12.022
Kohl M, Koch S, Keller M, Deigner HP. Biochips: Bright Future in Clinical Dx? J Biochip Tissue chip 2011, S1. DOI dx.doi.org/10.4172/2153-0777.S1-e003

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Dr. Reinhold Wasserkort