Department of Extracorporeal Immunomodulation

Publications and Patents

Publications

  • Koertge A, Wasserkort R, Wild T, Mitzner S. Extracorporeal Hemoperfusion as a Potential Therapeutic Option for Critical Accumulation of Rivaroxaban. Blood Purification 45 (2018), 126–128. dx.doi.org/10.1159/000484923
  • Koertge A, Wild T, Heskamp B, Folk M, Mitzner S, Wasserkort R. Thrombogenicity and long-term cytokine removal capability of a novel asymmetric triacetate membrane hemofilter. Journal of artificial organs 21 (2018), 4, S. 435-442. dx.doi.org/10.1007/s10047-018-1062-1
  • Peters F, Westphal C, Kramer A, Westerman R. Is the rise in the prevalence of renal replacement therapy at older ages the price for living longer? Frontiers in Public Health 6 (2018), 138, 7 S. dx.doi.org/10.3389/fpubh.2018.00138
  • Sauer M, Haubner C, Richter G, Ehler J, Mencke T, Mitzner S, Margraf S, Altrichter J, Doß S, Nöldge-Schomburg G v. Impaired cell viability and functionality of hepatocytes after incubation with septic plasma-results of a second prospective biosensor study. Frontiers in Immunology. 9 (2018), 1448. dx.doi.org/10.3389/fimmu.2018.01448
  • Sauer M, Richter G, Altrichter J, Wild T, Doß F, Mencke T, Ehler J, Doß S, Koch S, Schubert A, Nöldge-Schomburg G, Mitzner SR. Effects of Bioreactor-Oxygenation During Extracorporeal Granulocytes Treatment in Septic Patients. Therapeutic apheresis and dialysis 22 (2018), 4, S. 389-398. dx.doi.org/10.1111/1744-9987.12657
  • Schäffler H, Breitrück A. Clostridium difficile - from colonization to infection. Frontiers in Microbiology 9 (2018), 646. dx.doi.org/10.3389/fmicb.2018.00646
  • Frimmel S, Mitzner SR, Koball S. Immunoadsorption as a Long-Term Therapy in Recurrent Focal Segmental Glomerulosclerosis After Renal Transplantation. Therapeutic apheresis and dialysis. 21 (2017), 1, S. 108-109. dx.doi.org/10.1111/1744-9987.12487
  • Doß S, Potschka H, Doß F, Mitzner S, Sauer M. Hepatotoxicity of antimycotics used for invasive fungal infections: In vitro results. BioMed research international 2017 (2017), Art. 9658018, 10 S. dx.doi.org/10.1155/2017/9658018
  • Rekers NV, Bajema IM, Mallat MJ, Petersen B, Anholts JD, Swings GM, van Miert PP, Kerkhoff C, Roth J, Popp D, van Groningen MC, Baeten D, Goemaere N, Kraaij MD, Zandbergen M, Heidt S, van Kooten C, de Fijter JW, Claas FH, Eikmans M. Beneficial immune effects of myeloid-related proteins in kidney transplant rejection. American journal of transplantation. 16 (2016), 5, S. 1441-1455. dx.doi.org/10.1111/ajt.13634
  • Sauer M, Altrichter J, Haubner C, Pertschy A, Wild T, Doß F, Mencke T, Thomsen M, Ehler J, Henschel J, Doß S, Koch S, Richter G, Nöldge-Schomburg G, Mitzner SR. Bioartificial therapy of sepsis : Changes of norepinephrine-dosage in patients and influence on dynamic and cell based liver tests during extracorporeal treatments. BioMed research international. (2016), Art. 7056492, 11 S. dx.doi.org/10.1155/2016/7056492
  • Sombetzki M, Koslowski N, Doss S, Loebermann M, Trauner M, Reisinger EC, Sauer M. Biosensor for hepatocellular injury corresponds to experimental scoring of hepatosplenic schistosomiasis in mice. BioMed research international. (2016), Art. 1567254, 7 S. dx.doi.org/10.1155/2016/1567254
  • Sponholz C, Matthes K, Rupp D, Backaus W, Klammt S, Karailieva D, Bauschke A, Settmacher U, Kohl M, Clemens MG, Mitzner S, Bauer M, Kortgen A. Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure : A prospective, randomised crossover study. Critical care. 20(2016), Art. 2. dx.doi.org/10.1186/s13054-015-1159-3
  • Ehler J, Koball S, Sauer M, Mitzner S, Hickstein H, Benecke R, Zettl UK. Response to Therapeutic Plasma Exchange as a Rescue Treatment in Clinically Isolated Syndromes and Acute Worsening of Multiple Sclerosis: A Retrospective Analysis of 90 Patients. Plos One 2015 Aug 5;10(8):e0134583. DOI dx.doi.org/10.1371/journal.pone.0134583. eCollection 2015
  • Maruschke M, Riebold D, Holtfreter MC, Sombetzki M, Mitzner S, Loebermann M, Reisinger EC, Hakenberg OW. Pneumocystis pneumonia (PCP) and Pneumocystis jirovecii carriage in renal transplantation patients: a single-centre experience. Wien Klin Wochenschr. 2014 Dec;126(23-24):762-6.
  • Frimmel S, Schipper J, Henschel J, Yu TT, Mitzner SR, Koball S. First description of single-pass albumin dialysis combined with cytokine adsorption in fulminant liver failure and hemophagocytic syndrome resulting from generalized herpes simplex virus 1 infection. Liver Transpl. 2014 Dec;20(12):1523-4.
  • Klammt S, Mitzner SR, Reisinger EC, Stange J. No sustained impact of intermittent extracorporeal liver support on thrombocyte time course in a randomized controlled albumin dialysis trial. Ther Apher Dial. 2014 Oct;18(5):502-8.
  • Mencke T, Jacobs RM, Machmueller S, Sauer M, Heidecke C, Kallert A, Pau HW, Noeldge-Schomburg G, Ovari A. Intubating conditions and side effects of propofol, remifentanil and sevoflurane compared with propofol, remifentanil and rocuronium: a randomised, prospective, clinical trial. BMC Anesthesiology 2014; DOI dx.doi.org/10.1186/1471-2253-14-39.
  • Ehler J, Koball S, Sauer M, Hickstein H, Mitzner S, Benecke R, Zettl UK. Therapeutic plasma exchange in glucocorticosteroid-unresponsive patients with Clinically Isolated Syndrome. Therapeutic Apheresis and Dialysis. 2014 Oct;18(5):489-96.DOI dx.doi.org/10.1111/1744-9987.12176
  • Frimmel S, Schipper J, Henschel J, Yu TT, Mitzner SR, Koball S. First description of single-pass albumin dialysis combined with cytokine adsorption in fulminant liver failure and hemophagocytic syndrome resulting from generalized herpes simplex virus 1 infection. Liver Transplantation. 2014 Dec;20(12):1523-4. DOI dx.doi.org/10.1002/lt.24005
  • Klammt S, Mitzner SR, Reisinger EC, Stange J. No sustained impact of intermittent extracorporeal liver support on thrombocyte time course in a randomized controlled albumin dialysis trial. Therapeutic Apheresis and Dialysis. 2014 Oct;18(5):502-8. DOI dx.doi.org/10.1111/1744-9987.12124
  • Breitrück A, Sparmann G, Mitzner S, Kerkhoff C. Establishment of a novel extracorporeal bowel model to study luminal approaches to treat inflammatory bowel disease. Dis Model Mech. 2013; 6:1487-1493. DOI dx.doi.org/10.1242/dmm.011734
  • Bañares R, Nevens F, Stolze Larsen F, Jalan R, Albillos A, Dollinger M, Saliba F, Sauerbruch T, Klammt S, Ockenga J, Pares A, Wendon J, Brünnler T, Kramer L, Mathurin P, Mata MD, Gasbarrini A, Müllhaupt B, Wilmer A, Laleman W, Eefsen M, Sen S, Zipprich A, Tenorio T, Pavesi M, Schmidt HH, Mitzner S, Williams R, Arroyo V. Extracorporeal albumin dialysis with the molecular adsorbent recirculating system in acute-on-chronic liver failure: The RELIEF trial. Hepatology 57 (2013)3: 1153-1162. DOI dx.doi.org/10.1002/hep.26185
  • Mitzner S, Gloger M, Henschel J, Koball S. Improvement of hemodynamic and inflammatory parameters by combined hemoadsorption and hemodiafiltration in septic shock: A case report. Blood purification 35 (2013) 4: 314-315. DOI dx.doi.org/10.1159/000351206
  • Sauer M, Altrichter J, Mencke T, Klöhr S, Thomsen M, Kreutzer HJ, Nöldge-Schomburg G, Mitzner S. Role of different replacement fluids during extracorporeal treatment in a pig model of sepsis. Ther Apher Dial. 17 (2013) 1:84-92. DOI dx.doi.org/10.1111/j.1744-9987.2012.01103.x
  • Mitzner S. Stellenwert der MARS®-Dialyse beim Acute-on-chronic-Leberversagen: Role of MARS® dialysis in acute-on-chronic liver failure. Z Gastroenterol. 51 (2013) 10: 1193-1194. DOI dx.doi.org/10.1055/s-0033-1350351
  • Averill MM, Kerkhoff C, Bornfeldt KE. S100A8 and S100A9 in cardiovascular biology and disease. Arterioscler Thromb Vasc Biol. 32 (2012), 2, S. 223-9. DOI dx.doi.org/10.1161/ATVBAHA.111.236927.
  • Kerkhoff C, Voss A, Scholzen TE, Averill MM, Zänker KS, Bornfeldt KE. Novel insights into the role of S100A8/A9 in skin biology. Exp Dermatol. 21 (2012), 11, S. 822 - 6. DOI dx.doi.org/10.1111/j.1600-0625.2012.01571.x.
  • Kielstein JT, Beutel G, Fleig S, Steinhoff J, Meyer TN, Hafer C, Kuhlmann U, Bramstedt J, Panzer U, Vischedyk M, Busch V, Ries W, Mitzner S, Mees S, Stracke S, Nürnberger J, Gerke P, Wiesner M, Sucke B, Abu-Tair M, Kribben A, Klause N, Schindler R, Merkel F, Schnatter S, Dorresteijn EM, Samuelsson O, Brunkhorst R; Collaborators of the DGfN STEC-HUS registry. Best supportive care and therapeutic plasma exchange with or without eculizumab in Shiga-toxin-producing E. coli O104:H4 induced haemolytic-uraemic syndrome: an analysis of the German STEC-HUS registry. Nephrol Dial Transplant. 27 (2012), 10, S. 3807-15. DOI dx.doi.org/10.1093/ndt/gfs394.
  • Klammt S, Wojak HJ, Mitzner A, Koball S, Rychly J, Reisinger EC, Mitzner S. Albumin-binding capacity (ABiC) is reduced in patients with chronic kidney disease along with an accumulation of protein-bound uraemic toxins. Nephrol Dial Transplant. 27 (2012), 6, S. 2377-83. DOI dx.doi.org/10.1093/ndt/gfr616.
  • Klionsky DJ and 1269 others. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8 (2012), 4, S. 445 - 544. DOI dx.doi.org/10.4161/auto.19496.
  • Maletzki C, Bodammer P, Breitrück A, Kerkhoff C. S100 proteins as diagnostic and prognostic markers in colorectal and hepatocellular carcinoma. Hepat Mon. 2012, 12 (10 HCC):e7240. DOI dx.doi.org/10.5812/hepatmon.7240.
  • Sauer M, Altrichter J, Mencke T, Klöhr S, Thomsen M, Kreutzer HJ, Nöldge-Schomburg G, Mitzner SR. Plasma separation by centrifugation and subsequent plasma filtration: impact on survival in a pig model of sepsis. Ther Apher Dial. 16 (2012), 3, S. 205-12. DOI dx.doi.org/10.1111/j.1744-9987.2011.01055.x.
  • Sauer M, Haubner C, Mencke T, Nöldge-Schomburg G, Mitzner S, Altrichter J, Stange J. Impaired cell functions of hepatocytes incubated with plasma of septic patients. Inflamm Res. 61 (2012), 6, S. 609-16. DOI dx.doi.org/10.1007/s00011-012-0451-9.
  • Voss A, Bode G, Kerkhoff C. Double-stranded RNA induces IL-8 and MCP-1 gene expression via TLR3 in HaCaT-keratinocytes. Inflamm Allergy Drug Targets. 11 (2012), 5, S. 397-405.
  • Voss A, Gescher K, Hensel A, Nacken W, Zänker KS, Kerkhoff C. Double-stranded RNA induces S100 gene expression by a cycloheximide-sensitive factor. FEBS Lett. 586 (2012), 2, S. 196-203. DOI dx.doi.org/10.1016/j.febslet.2011.12.022
  • Kohl M, Koch S, Keller M, Deigner HP. Biochips: Bright Future in Clinical Dx? J Biochip Tissue chip 2011, S1. DOI dx.doi.org/10.4172/2153-0777.S1-e003

 

Patents

  • Altrichter, J, Mitzner, S, Lübcke A, Selleng K, Doss F, Koch S. Verfahren zum Herstellen einer Leukozytenpräparation und Leukozytenpräparation. METHOD FOR PRODUCING A LEUKOCYTE PREPARATION, AND LEUKOCYTE PREPARATION. DE 102012209673 A1: 20120608
  • Mitzner S, Kerkhoff C, Bodammer P, Breitrück A, Krüger G. Mineralische Verbindung zur Reduzierung von anorganischen Phosphaten, insbesondere im Rahmen einer Nierenersatztherapie. CLAY MINERAL FOR REDUCING INORGANIC PHOSPHATES, IN PARTICULAR IN RENAL REPLACEMENT THERAPY. DE 102012209411 A1: 20120604
  • Mitzner S, Kerkhoff C, Emmrich F, Breitrueck A, Bodammer P, Krueger G, Dallwig R. Mineralische Verbindung und deren Modifikationen zur Anwendung bei chronisch-entzündlichen Darmerkrankungen. CLAY MINERAL AND ITS MODIFICATIONS FOR USE IN THE TREATMENT OF CHRONIC INFLAMMATORY BOWEL DISEASES. DE 102012207471 A1: 20120504