Vaccine Technologies

Publications

  • Bauer BU, Runge M, Campe A, Henning KJ, Mertens-Scholz K, Boden K, Sobotta K, Frangoulidis D, Knittler MR, Matthiesen S, Berens C, Lührmann A, Fischer SF, Ulbert S, Makert GR, Ganter M. Coxiella burnetii: ein Übersichtsartikel mit Fokus auf das Infektions­geschehen in deutschen Schaf- und Ziegen­herden / a review focusing on infections in German sheep and goat flocks. Berliner und Münchener tierärztliche Wochenschrift 133 (2020) 3-4, Seite 184-200. dx.doi.org/10.2376/0005-9366-19030
  • Berneck BS, Rockstroh A, Fertey J, Grunwald T, Ulbert S. A recombinant zika virus envelope protein with mutations in the conserved fusion loop leads to reduced antibody cross-reactivity upon vaccination. Vaccines 8 (2020) 4, Artikel-Nr.: 603, 10 Seiten. dx.doi.org/10.3390/vaccines8040603
  • Fertey J, Bayer L, Kähl S, Haji RM, Burger-Kentischer A, Thoma M, Standfest B, Schönfelder J, Portillo Casado J, Rögner FH, Baums CG, Grunwald T, Ulbert S. Low-Energy Electron Irradiation Efficiently Inactivates the Gram-Negative Pathogen Rodentibacter pneumotropicus-A New Method for the Generation of Bacterial Vaccines with Increased Efficacy. Vaccines (Basel). 2020 Mar 2;8(1):113. dx.doi.org/10.3390/vaccines8010113
  • Fertey J, Thoma M, Beckmann J, Finkensieper J, Reißhauer S, Berneck BS, Issmail L, Schönfelder J, Casado JP, Poremba A, Rögner F-H, Standfest B, Makert GR, Walcher L, Kistenmacher A-K, Fricke S, Grunwald T, Ulbert S, Bayer L. Automated application of low energy electron irradiation enables inactivation of pathogen- and cell-containing liquids in biomedical research and production facilities. Scientific reports 10 (2020) 1, Artikel-Nr.: 12786, 14 Seiten. dx.doi.org/10.1038/s41598-020-69347-7
  • Körner S, Makert G, Mertens-Scholz K, Henning K, Pfeffer M, Starke A, Nijhof AM, Ulbert, S. Uptake and fecal excretion of coxiella burnetii by Ixodes ricinus and dermacentor marginatus ticks. Parasites & Vectors 13 (2020), 11 Seiten. dx.doi.org/10.1186/s13071-020-3956-z
  • Moreira-Soto A, Souza Sampaio G de, Pedroso C, Postigo-Hidalgo I, Berneck BS, Ulbert S, Brites CR, Netto EM, Drexler JF. Rapid decline of Zika virus NS1 antigen-specific antibody responses, northeastern Brazil. Virus genes (2020) short report, 6 Seiten. dx.doi.org/10.1007/s11262-020-01772-2
  • Shehata AA, Basiouni S, Ali A, Fawzy M, Hafez HM, Ulbert S, Vahlenkamp TW. Immunization of turkeys with a DNA vaccine expressing the haemagglutinin gene of low pathogenic avian influenza virus subtype H9N2. Journal of virological methods 284 (2020) Artikel-Nr.: 113938. dx.doi.org/10.1016/j.jviromet.2020.113938
  • Bozza FA, Moreira-Soto A, Rockstroh A, Fischer C, Nascimento AD, Calheiros AS, Drosten C, Bozza PT, Souza TML, Ulbert S, Drexler JF. Differential Shedding and Antibody Kinetics of Zika and Chikungunya Viruses, Brazil. Emerg Infect Dis. 2019 Feb;25(2):311-315. dx.doi.org/10.3201/eid2502.180166.
  • Fertey J, Bayer L, Kähl S, Haji RM, Burger-Kentischer A, Thoma M, Standfest B, Schönfelder J, Portillo Casado J, Rögner FH, Baums CG, Grunwald T, Ulbert S. Low-Energy Electron Irradiation Efficiently Inactivates the Gram-Negative Pathogen Rodentibacter pneumotropicus-A New Method for the Generation of Bacterial Vaccines With Increased Efficacy. Vaccines (Basel). 2020 Mar 2;8(1):113. dx.doi.org/10.3390/vaccines8010113.
  • Körner S, Makert GR, Mertens-Scholz K, Henning K, Pfeffer M, Starke A, Nijhof AM, Ulbert S. Uptake and Fecal Excretion of Coxiella Burnetii by Ixodes Ricinus and Dermacentor Marginatus Ticks. Parasit Vectors. 2020 Feb 14;13(1):75. dx.doi.org/10.1186/s13071-020-3956-z.
  • Rockstroh A, Barzon L, Kumbukgolla W, Su HX, Lizarazo E, Vincenti-Gonzalez MF, Tami A, Ornelas AMM, Aguiar RS, Cadar D, Schmidt-Chanasit J, Ulbert S. Dengue Virus IgM Serotyping by ELISA with Recombinant Mutant Envelope Proteins. Emerg Infect Dis. 2019 Jan 17;25(1). dx.doi.org/10.3201/eid2501.180605.
  • Rockstroh A, Moges B, Berneck BS, Sattler T, Revilla-Fernández S, Schmoll F, Pacenti M, Sinigaglia A, Barzon L, Schmidt-Chanasit J, Nowotny N, Ulbert S. Specific Detection and Differentiation of Tick-Borne Encephalitis and West Nile Virus Induced IgG Antibodies in Humans and Horses. Transbound Emerg Dis. 2019 Jul;66(4):1701-1708. dx.doi.org/10.1111/tbed.13205. Epub 2019 Apr 29.
  • Thabet A, Schmäschke R, Fertey J, Bangoura B, Schönfelder J, Lendner M, Ulbert S, Daugschies A. Eimeria Tenella Oocysts Attenuated by Low Energy Electron Irradiation (LEEI) Induce Protection Against Challenge Infection in Chickens. Vet Parasitol. 2019 Feb;266:18-26. dx.doi.org/10.1016/j.vetpar.2019.01.001. Epub 2019 Jan 6.
  • Ulbert S. West Nile Virus Vaccines - Current Situation and Future Directions. Hum Vaccin Immunother. 2019;15(10):2337-2342. dx.doi.org/10.1080/21645515.2019.1621149. Epub 2019 Jul 10.
  • Zhong Z, Portela Catani JP, Mc Cafferty S, Couck L, Van Den Broeck W, Gorlé N, Vandenbroucke RE, Devriendt B, Ulbert S, Cnops L, Michels J, Ariën KK, Sanders NN. Immunogenicity and Protection Efficacy of a Naked Self-Replicating mRNA-Based Zika Virus Vaccine. Vaccines (Basel). 2019 Aug 23;7(3):96. dx.doi.org/10.3390/vaccines7030096.
  • Bayer L, Fertey J, Ulbert S, Grunwald T. Immunization with an adjuvanted low-energy electron irradiation inactivated respiratory syncytial virus vaccine shows immunoprotective activity in mice. Vaccine. 2018 Mar 14;36(12):1561-1569. dx.doi.org/10.1016/j.vaccine.2018.02.014
  • Rockstroh A, Moges B, Barzon L, Sinigaglia A, Palù G, Kumbukgolla W, Schmidt-Chanasit J, Sarno M, Brites C, Moreira-Soto A, Drexler JF, Ferreira OC, Ulbert S. Specific detection of dengue and Zika virus antibodies using envelope proteins with mutations in the conserved fusion loop. Emerg Microbes Infect. 2017 Nov 8;6(11):e99. dx.doi.org/10.1038/emi.2017.87.
  • Netto EM, Moreira-Soto A, Pedroso C, Höser C, Funk S, Kucharski AJ, Rockstroh A, Kümmerer BM, Sampaio GS, Luz E, Vaz SN, Dias JP, Bastos FA, Cabral R, Kistemann T, Ulbert S, de Lamballerie X, Jaenisch T, Brady OJ, Drosten C, Sarno M, Brites C, Drexler JF. High Zika Virus Seroprevalence in Salvador, Northeastern Brazil Limits the Potential for Further Outbreaks. MBio. 2017 Nov 14;8(6). pii: e01390-17. dx.doi.org/10.1128/mBio.01390-17.
  • Rockstroh A, Moges B, Barzon L, Sinigaglia A, Palù G, Kumbukgolla W, Schmidt-Chanasit J, Sarno M, Brites C, Moreira-Soto A, Drexler JF, Ferreira OC, Ulbert S. Specific detection of dengue and Zika virus antibodies using envelope proteins with mutations in the conserved fusion loop. Emerg Microbes Infect. 2017 Nov 8;6(11):e99. dx.doi.org/10.1038/emi.2017.87.
  • Fertey J, Bayer L, Grunwald T, Pohl A, Beckmann J, Gotzmann G, Casado JP, Schönfelder J, Rögner FH, Wetzel C, Thoma M, Bailer SM, Hiller E, Rupp S, Ulbert S. Pathogens Inactivated by Low-Energy-Electron Irradiation Maintain Antigenic Properties and Induce Protective Immune Responses. Viruses. 2016 Nov 23;8(11). pii: E319.
  • Makert GR, Vorbrüggen S, Krautwald-Junghanns ME, Voss M, Sohn K, Buschmann T, Ulbert S. A method to identify protein antigens of Dermanyssus gallinae for the protection of birds from poultry mites. Parasitol Res. 2016 Jul;115(7):2705-13. DOI dx.doi.org/10.1007/s00436-016-5017-2
  • Fischer D, Angenvoort J, Ziegler U, Fast C, Maier K, Chabierski S, Eiden M, Ulbert S, Groschup MH, Lierz M. DNA vaccines encoding the envelope protein of West Nile virus lineages 1 or 2 administered intramuscularly, via electroporation and with recombinant virus protein induce partial protection in large falcons (Falco spp.). Vet Res. 2015 Aug 17;46(1):87. DOI dx.doi.org/10.1186/s13567-015-0220-1.
  • Rockstroh A, Barzon L, Pacenti M, Palù G, Niedrig M, Ulbert S. Recombinant Envelope-Proteins with Mutations in the Conserved Fusion Loop Allow Specific Serological Diagnosis of Dengue-Infections. PLoS Negl Trop Dis. 2015 Nov 13;9(11):e0004218. DOI dx.doi.org/10.1371/journal.pntd.0004218
  • Barzon L, Pacenti M, Franchin E, Squarzon L, Sinigaglia A, Ulbert S, Cusinato R, Palù G. Isolation of West Nile virus from urine samples of patients with acute infection. Journal of Clinical Microbiology. 2014 Sep;52(9):3411-3. DOI dx.doi.org/10.1128/JCM.01328-14.
  • Chabierski S, Barzon L, Papa A, Niedrig M, Bramson JL, Richner JM, Palù G, Diamond MS, Ulbert S. Distinguishing West Nile virus infection using a recombinant envelope protein with mutations in the conserved fusion-loop. BMC Infectious Diseases. 2014 May 9;14:246. DOI dx.doi.org/10.1186/1471-2334-14-246.
  • De Filette M, Chabierski S, Andries O, Ulbert S, Sanders NN. T cell epitope mapping of the e-protein of west nile virus in BALB/c mice. PLoS One. 2014 Dec 15;9(12):e115343.DOI: dx.doi.org/10.1371/journal.pone.0115343.
  • De Filette M, Soehle S, Ulbert S, Richner J, Diamond MS, Sinigaglia A, Barzon L, Roels S, Lisziewicz J, Lörincz O, Sanders NN.  Vaccination of mice using the West Nile virus E-protein in a DNA prime-protein boost strategy stimulates cell-mediated immunity and protects mice against a lethal challenge. PLoS One. 2014 Feb 4;9(2):e87837.DOI: dx.doi.org/10.1371/journal.pone.0087837.
  • Friedrich S, Schmidt T, Geissler R, Lilie H, Chabierski S, Ulbert S, Liebert UG, Golbik RP, Behrens SE. AUF1 p45 promotes West Nile virus replication by an RNA chaperone activity that supports cyclization of the viral genome. Journal of Virology. 2014 Oct;88(19):11586-99.DOI: dx.doi.org/10.1128/JVI.01283-14.
  • Magnusson SE, Karlsson KH, Reimer JM, Corbach-Söhle S, Patel S, Richner JM, Nowotny N, Barzon L, Bengtsson KL, Ulbert S, Diamond MS, Stertman L. Matrix-M™ adjuvanted envelope protein vaccine protects against lethal lineage 1 and 2 West Nile virus infection in mice. Vaccine. 2014 Feb 7;32(7):800-8. DOI dx.doi.org/10.1016/j.vaccine.2013.12.030.
  • Ulbert S, Magnusson SE. Technologies for the development of West Nile virus vaccines. Future Microbiology. 2014;9(10):121-32. DOI dx.doi.org/10.2217/fmb.14.67.
  • Verstrepen BE, Fagrouch Z, van Heteren M, Buitendijk H, Haaksma T, Beenhakker N, Palù G, Richner JM, Diamond MS, Bogers WM, Barzon L, Chabierski S, Ulbert S, Kondova I, Verschoor EJ. Experimental infection of rhesus macaques and common marmosets with a European strain of West Nile virus. PLoS Neglected Tropical Diseases. 2014 Apr 17;8(4):e2797. DOI dx.doi.org/10.1371/journal.pntd.0002797.
  • Verstrepen BE, Oostermeijer H, Fagrouch Z, Van Heteren M, Niphuis H, Haaksma T, Kondova I, Bogers WM, De Filette M, Sanders N, Stertman L, Magnusson S, Lörincz O, Lisziewicz J, Barzon L, Palù G, Diamond MS, Chabierski S, Ulbert S, Verschoor E.J. Vaccine-induced protection of rhesus macaques against plasma viremia after intradermal infection with a European lineage 1 strain of West Nile virus. PLoS One, 9 (2014), e112568. DOI dx.doi.org/10.1371/journal.pone.0112568
  • Chabierski S, Makert GR, Kerzhner A, Barzon L, Fiebig P, Liebert UG, Papa A, Richner JM, Niedrig M, Diamond MS, Palù G, Ulbert S.  Antibody responses in humans infected with newly emerging strains of West Nile Virus in Europe. 2013, PLoS ONE, 8(6), e66507.
  • De Filette MC, Ulbert S, Diamond M, Sanders NN. Recent progress in West Nile virus diagnosis and vaccination. Vet Res.43 (2012), 1, S. 16. doi: 10.1186/1297-9716-43-16.
  • Schneeweiss A, Chabierski S, Salomo M, Delaroque N, Al-Robaiy S, Grunwald T, Bürki K, Liebert UG, Ulbert S. A DNA vaccine encoding the E protein of West Nile Virus is protective and can be boosted by recombinant domain DIII. Vaccine, 29 (2011), S. 6352-6357.
  • Ulbert S. West Nile Virus: The Complex Biology of an Emerging Pathogen. Intervirology, 54 (2011), S. 171-184.
  • Schneeweiss A, Buyens K, Giese M, Sanders N, Ulbert S. Synergistic effects between natural histone mixtures and polyethylenimine in non-viral gene delivery in vitro. Int J Pharm. 400 (2010), 1-2, S. 86-95.
  • Heinrich A, Riethmüller D, Gloger M, Schusser GF, Giese M, Ulbert S. RNA interference protects horse cells in vitro from infection with Equine Arteritis Virus. Antivir Res, 81 (2009), 3, S. 209-216.