Medical Bioinformatics

Competencies

Precise cell analyses

  • Multi-modal individual cell analyses: A combination of various analysis technologies, such as next generation sequencing, multi-parameter mass spectrometry and microfluidic systems for measuring various cell characteristics
  • Multiomics: Facilitate the concurrent characterization of numerous molecular and cellular markers in tissue samples, including whole-genome analyses, transcriptome analyses and epigenome analyses
  • Multiparameter immunophenotyping: High-resolution characterization of immune cells through the simultaneous analysis of various surface and intracellular markers, permits recording of the functional states of the immune system
  • Spatially resolved transcriptome analyses: High-resolution characterization of cell interactions, analyses of the functional states of immune cells in tumors and their surrounding areas (tumor micro-environment)
  • ISO 9001:2015 certified quality management system

Computer-supported biomedicine

  • Data-based machine learning
  • Identification of molecular biology and cellular patterns, identification and validation of biomarkers, predictions regarding therapy success and side-effects
  • In silico clinical studies: Digital patient twins, development of personalized therapies, planning of clinical studies
  • Computer-supported biology: Modeling and classification of RNA secondary structure motifs, characterization of cell interactions, description of ligand-receptor interactions in tissue samples

Software engineering for biomedical applications

  • ·Development of software components for medical devices and in vitro diagnostics
  • Development of tailor-made bioinformatics pipelines for applications in lab diagnostics or companion diagnostics for clinical studies
  • Development of FHIR profiles for applications in lab diagnostics
  • Software components are planned and implemented according to the IEC 62304 and ISO 14971 standards to ensure compliance with the regulatory requirements in healthcare.
  • ISO 9001:2015 certified quality management system