Fraunhofer Institute for Cell Therapy and Immunology IZI
Fraunhofer Institute for Cell Therapy and Immunology IZI

Medicinal chemistry / Small Molecules

Publications

  • Benedyk-Machaczka M, Mydel P, Mäder K, Kaminska M, Taudte N, Naumann M, Kleinschmidt M, Sarembe S, Kiesow A, Eick S, Buchholz M. Preclinical validation of MIN-T: a novel controlled-released formulation for the adjunctive local application of minocycline in periodontitis. Antibiotics (Basel). 2024, 13 (11): 1012. doi: 10.3390/antibiotics13111012
  • Gnoth K, Bär JW, Rosche F, Rahfeld J-U, Demuth H-U. Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme. PLoS One. 2024, 19 (4): e0289239. doi: 10.1371/journal.pone.0289239. eCollection 2024.
  • Herrmann A, Gege C, Wangen C, Wagner S, Kögler M, Cordsmeier A, Irrgang P, Ip W-H, Weil T, Hunszinger V, Groß R, Heinen N, Pfaender S, Reuter S, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Grunwald T, Hietel B, Cynis H, Münch J, Sparrer K M J, Ensser A, Tenbusch M, Dobner T, Vitt D, Kohlhof H, Hahn F. Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity. Antiviral Res. 2024, 231: 106008. doi: 10.1016/j.antiviral.2024.106008. Epub 2024 Sep 19.
  • Issmail L, Ramsbeck D, Jäger C, Henning T, Kleinschmidt M, Buchholz M, Grunwald T. Novel Small Molecule Inhibitor of Respiratory Syncytial Virus Entry. 2023, Antiviral Research
  • Tan K, Jäger C, Geissler S, Schlenzig D, Buchholz M, Ramsbeck D. Synthesis and Structure-Activity Relationships of Pyrazole-based Inhibitors of Meprin α and β. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2165648. doi: 10.1080/14756366.2023.2165648
  • Ramsbeck D, Taudte N, Jaenckel N, Strich S, Rahfeld J-U, Buchholz M. Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase. Pharmaceuticals (Basel). 2021 Nov 23;14(12):1206. doi: 10.3390/ph14121206
  • Tan K, Jäger C, Körschgen H, Geissler S, Schlenzig D, Buchholz M, Stöcker W, Ramsbeck D. Heteroaromatic inhibitors of the astacin proteinases Meprin α, Meprin β and Ovastacin discovered by a scaffold hopping approach. ChemMedChem. 2021 Mar 18;16(6):976-988. doi: 10.1002/cmdc.202000822. Epub 2020 Dec 23.
  • Kupski O, Funk L-M, Sautner V, Seifert F, Worbs B, Ramsbeck D, Meyer F, Diederichsen U, Buchholz M, Schilling S, Demuth H-U, Tittmann K. Hydrazides are potent transition-state analogs for glutaminyl cyclase implicated in the pathogenesis of Alzheimer’s Disease. Biochemistry. 2020 Jul 21;59(28):2585-2591. doi: 10.1021/acs.biochem.0c00337. Epub 2020 Jun 29.
  • Ramsbeck D, Hamann A, Richter G, Schlenzig D, Geissler S, Nykiel V, Cynis H, Schilling S, Buchholz M. Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors. J Med Chem. 2018 May 24;61(10):4578-4592. doi: 10.1021/acs.jmedchem.8b00330. Epub 2018 May 7.