Fraunhofer Institute for Cell Therapy and Immunology IZI
Fraunhofer Institute for Cell Therapy and Immunology IZI

Medicinal chemistry / Small Molecules

Publications

  • Eick S, Taudte N, Ramsbeck D, Magdon A, Sculean A, Potempa J, Buchholz M. Effect of a bacterial glutaminyl cyclase inhibitor on multi-species-biofilms. Front. Oral Health, 01 December 2025, Sec. Oral Infections and Microbes, Volume 6 - 2025. doi: 10.3389/froh.2025.1716625
  • Haupt J, Keminer O, Neser C, Windshügel B, Wiltzsch V, Schmidt J, Pliushcheuskaya P, Künze G, Scholz U, Müller C, Oliveira da Rocha G H, Biermann M, Zdzieblo D, Metzger M, Schiefke I, Neurath M, Siegmund B, Claussen C, Köhl U, Geisslinger G, Buchholz M, Kalkhof S, Lehmann J. Novel aryl hydrocarbon receptor agonists as potential anti-inflammatory therapeutics: Identification and validation through drug repurposing. Biochem Pharmacol. 2025, 240: 117066. doi: 10.1016/j.bcp.2025.117066
  • Benedyk-Machaczka M, Mydel P, Mäder K, Kaminska M, Taudte N, Naumann M, Kleinschmidt M, Sarembe S, Kiesow A, Eick S, Buchholz M. Preclinical validation of MIN-T: a novel controlled-released formulation for the adjunctive local application of minocycline in periodontitis. Antibiotics (Basel). 2024, 13 (11): 1012. doi: 10.3390/antibiotics13111012
  • Gnoth K, Bär JW, Rosche F, Rahfeld J-U, Demuth H-U. Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme. PLoS One. 2024, 19 (4): e0289239. doi: 10.1371/journal.pone.0289239. eCollection 2024.
  • Herrmann A, Gege C, Wangen C, Wagner S, Kögler M, Cordsmeier A, Irrgang P, Ip W-H, Weil T, Hunszinger V, Groß R, Heinen N, Pfaender S, Reuter S, Klopfleisch R, Uhlig N, Eberlein V, Issmail L, Grunwald T, Hietel B, Cynis H, Münch J, Sparrer K M J, Ensser A, Tenbusch M, Dobner T, Vitt D, Kohlhof H, Hahn F. Orally bioavailable RORγ/DHODH dual host-targeting small molecules with broad-spectrum antiviral activity. Antiviral Res. 2024, 231: 106008. doi: 10.1016/j.antiviral.2024.106008. Epub 2024 Sep 19.
  • Issmail L, Ramsbeck D, Jäger C, Henning T, Kleinschmidt M, Buchholz M, Grunwald T. Novel Small Molecule Inhibitor of Respiratory Syncytial Virus Entry. 2023, Antiviral Research
  • Tan K, Jäger C, Geissler S, Schlenzig D, Buchholz M, Ramsbeck D. Synthesis and Structure-Activity Relationships of Pyrazole-based Inhibitors of Meprin α and β. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2165648. doi: 10.1080/14756366.2023.2165648
  • Ramsbeck D, Taudte N, Jaenckel N, Strich S, Rahfeld J-U, Buchholz M. Tetrahydroimidazo[4,5-c]pyridine-Based Inhibitors of Porphyromonas gingivalis Glutaminyl Cyclase. Pharmaceuticals (Basel). 2021 Nov 23;14(12):1206. doi: 10.3390/ph14121206
  • Tan K, Jäger C, Körschgen H, Geissler S, Schlenzig D, Buchholz M, Stöcker W, Ramsbeck D. Heteroaromatic inhibitors of the astacin proteinases Meprin α, Meprin β and Ovastacin discovered by a scaffold hopping approach. ChemMedChem. 2021 Mar 18;16(6):976-988. doi: 10.1002/cmdc.202000822. Epub 2020 Dec 23.
  • Kupski O, Funk L-M, Sautner V, Seifert F, Worbs B, Ramsbeck D, Meyer F, Diederichsen U, Buchholz M, Schilling S, Demuth H-U, Tittmann K. Hydrazides are potent transition-state analogs for glutaminyl cyclase implicated in the pathogenesis of Alzheimer’s Disease. Biochemistry. 2020 Jul 21;59(28):2585-2591. doi: 10.1021/acs.biochem.0c00337. Epub 2020 Jun 29.
  • Ramsbeck D, Hamann A, Richter G, Schlenzig D, Geissler S, Nykiel V, Cynis H, Schilling S, Buchholz M. Structure-Guided Design, Synthesis, and Characterization of Next-Generation Meprin β Inhibitors. J Med Chem. 2018 May 24;61(10):4578-4592. doi: 10.1021/acs.jmedchem.8b00330. Epub 2018 May 7.