Fraunhofer Institute for Cell Therapy and Immunology IZIChemical analytics
Pharmaceutical analytics
- Development and validation of LC-MRM methods for the quantification of biomolecules (small and large molecules) in complex biological matrices like body fluids and tissue homogenates
- Analytical services for preclinical studies (GLP/non-GLP) in the fields of pharmacokinetics and toxicology (LC-UV/Vis, LC-MRM)
- Quality control for intermediates and final products of biotechnological and pharmaceutical production processes (LC-UV/Vis, LC-MS/MS, MALDI-TOF/TOF)
- Characterisation of active pharmaceutical ingredients (API) concerning purity, stability, release and permeability (LC-UV/Vis, LC-MRM, LC-MS/MS, MALDI-TOF/TOF)
Peptide and protein analytics
- Quality control/characterisation of synthetic peptides: purity analysis, determination of molecular mass and amino acid sequence, identification of impurities
- Quality control/characterization of recombinant proteins: purity analysis, identification of impurities, determination of molecular mass and amino acid sequence, identification of posttranslational modifications, stability studies, release experiments
- Development of analytical methods for the identification and quantification of peptides and proteins as well as of posttranslational modifications in complex biological matrices