Fraunhofer Institute for Cell Therapy and Immunology IZIChemical analytics
ParoStop - Controlled Release-Drug Delivery Systems (CR-DDS) for innovative and selective drugs for treating bacterial infections of the periodontium
Period
8/2/2021 – 30/4/2022
Project aim
Systematic examination of the drug release under regulatory preclinical conditions
- Characterisation of the formulation in terms of drug release with the help of LC-MS/MS mass spectroscopy
- Examination of drug release under regulatory preclinical conditions (GLP analytics)
- Examinations regarding the long-term stability of the formulations under regulatory preclinical conditions (GLP analytics)Projektleitung
Project management
Dr. Martin Kleinschmidt
Profiling of inhibitors of bacterial Glutaminyl cyclases as drug prototypes for novel periodontitis treatments
Partial project 1 – Preclinical profiling of drug candidates
Period
3/2/2022 – 31/12/2022
Project aim
Characterisation of drug prototypes for preclinical development
- Drug concentration determination using HPLC-MS/MS: Development of methods for selected compounds
- Initial characterisation of pharmacokinetic (ADME) parameters of selected compounds
- Bioavailability studies in rat animal models to determine substance-specific parameters (Cmax, tmax and AUC)
Project management
Dr. Martin Kleinschmidt
