Salmonella enterica causes various diseases including food poisoning and typhoid fever. We provide a mouse model of infectious disease using Salmonella enterica to test antibacterial agents and potential therapeutics. Furthermore, immunomodulatory / immunotoxic effects of test substances can be revealed by infecting mice with a sublethal dose of Salmonella enterica and simultaneous exposure to the test substance. Mice can also be infected with a median lethal (LD50) infection dose to determine the impact of test substances on mortality. The model can thus be used as therapy and / or toxicity model.