Fraunhofer Institute for Cell Therapy and Immunology IZISpecies
Mouse
Fields of application
The Morris Water Maze is a test to study hippocampal-dependent spatial learning and memory. The test uses the natural aversion of mice to swim in water. They are placed into a water basin (Ø 1.2 m, 26 °C) and have to find a platform that is hidden under the surface. For orientation several markers are placed around the maze.
The model can be used for the following fields of application:
- Central nervous system damage
- Disease effects on spatial learning and memory
- Drug administration
- Therapeutic efficacy
- Proof of concept
Endpoints / outcome parameter
- Ability for spatial learning
- Memory functions
Readout parameter
- Swimming distance [cm]
- Velocity [cm/s]
- Time to find platform [sec]
- Time spend in quadrants [sec or %]
Quality management and validation
- Controls
- Randomisation
- Blinded data collection and analysis
- Biometric Expertise
- Internal quality management