The analysis of toxicity / immunotoxicity of substances is essential to establish limit values for toxic compounds and maximum tolerable doses (MTDs) for drugs. The toxicity of a substance is not only based on its reactivity in a healthy organism, but can be substantially modified during an active immune response. We supply a wide range of in vitro models to investigate toxicity and immunotoxicity of potentially hazardous agents or drug candidates. We also provide mouse models to analyse the impact of substances in vivo, either in the healthy organism or in the presence of an active immune response following infection.