SENSE-CoV2 – Analysis of the innate immune recognition of SARS-CoV-2 using recombinant viruses

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Containment of the corona pandemic is hampered by a significant proportion of infected persons showing very few or no symptoms. The fact that SARS-CoV-2 is able to multiply without signs of inflammation suggests that innate immune control against SARS-CoV-2 may be deregulated and less effective.

Within the framework of the SENSE-CoV2 project funded by the German Federal Ministry of Education and Research (BMBF), the research team of the Friedrich-Alexander University of Erlangen-Nürnberg and the Fraunhofer IZI aims to characterize mechanisms that enable SARS-CoV-2 to escape detection by the human innate immune system.

The identification of viral proteins that prevent early immune control and their characterization in infection experiments will provide important foundations and new target structures for a possible development of antiviral drugs aiming at improved control of the virus by the innate immune system.

Partner

Friedrich Alexander University of Erlangen-Nürnberg (FAU)  |  www.nat.fau.eu

Support

German Federal Ministry of Education and Research (BMBF)