PIONEER is a European Network of Excellence for Big Data in Prostate Cancer, consisting of 32 partners across 9 countries, among them Fraunhofer IZI. In an important step forward the first datasets have been transferred into the PIONEER Big Data platform by PIONEER partner Erasmus University Medical Centre (MC). Through the application of Big Data and the analyses of real-world evidence PIONEER aims to change the prostate cancer landscape to improve the health and social care received by all prostate cancer patients and their families. Fraunhofer IZI works in the framework of the PIONEER project on the topics data harmonisation of transcriptome-wide expression studies as well as statistical data analyses to identify and confirm biomarkers.