Molecular nanotechnology and biochemistry

We utilize DNA-based nano-engineering methods such as 2D and 3D DNA origami, DNA bricks, DNA tiles and others to design and synthesize custom, biofunctional nanoparticles. These are used to target biological systems such as cells and viruses, as well as to generate functional biomaterials.

Nanoscale components such as peptides, proteins, DNA or antibodies are integrated with various types of delivery systems such as lipid nanoparticles (LNPs), to generate functional, targeted nanocarriers.

Standard and custom enzyme-linked assays such as ELISA are used to quantify the presence of selected analytes in solutions. Customized capture components can be synthesized to integrate specific capture ligands, or utilize templated multivalence for complex analytes such as viral proteins.

A variety of methods are used to uncover the fundamental properties of biomaterials and nanoparticles, including atomic force microscopy (AFM), dynamic light scattering (DLS), single-particle tracking, differential scanning fluorimetry (nanoDFS), bulk shear rheology, single-particle rheology, and many more. 

Using different bioconjugation methods, protein-based molecules such as antibodies, enzymes, nanobodies or other formats can be chemically modified with other accessory molecules. These include custom dye modifications for applications like flow cytometry, cytotoxic moelcules for the generation of antibody-drug conjugates (ADCs), or even more complex functionalities like kinetic DNA scaffolds.