Fraunhofer Institute for Cell Therapy and Immunology IZINext-Generation Diagnostics
Our offer for preclinical and clinical applications
Classical NGS methods
- Whole transcriptome sequencing (mRNA, totalRNA): gene expression profiling for biological and/or medical questions (e.g. cancers, rare syndromes) as well as translational research
- Amplicon-based sequencing: sequencing of selected genomic regions for precision oncology as well as testing for hereditary diseases
- Genome sequencing / exome sequencing: genome profiling for cancer studies as well as translational research
- Small genome sequencing: targeted or complete sequencing of genomes with low complexity (such as bacteria, viruses or phages)
Advanced NGS methods
- Single cell sequencing and multiomics: transcriptome profiling and parallel detection of surface proteins of single cells. For example, for functional control of therapeutic CARs (e.g. CAR-T cells, CAR-NK cells) and monitoring of therapy success in patients.
- Spatial transciptomics: Spatially resolved gene expression profiling in tissues close to single cell resolution, for example for parallel molecular and imaging characterization of tumor, tumor infiltrating immune cells and tumor microenvironment.