Here is an overview of the methods we use.
The Bioinformatics Unit develops and establishes computer-aided methods for the identification and verification of new biomarkers for personalized diagnosis and prognosis of diseases as well as for the detection of novel therapeutic targets.
It has only been known for a few years that a multitude of RNA molecules are not translated into proteins. The latest scientific findings show that those non-coding RNAs (ncRNAs) perform fine-regulatory tasks in gene regulation and are therefore suitable as markers for individual disease stages as well as for disease progression. The unit develops strategies for the efficient processing and (statistical) analysis of molecular biological data that has been gained from extensive clinical cohorts based on next-generation sequencing, microarrays, as well as by DNA-, RNA-, and epigenetic analytics in order to detect disease relevant ncRNAs. The gene regulatory mechanisms of ncRNAs are modeled by using methods from systems biology and RNA computational biology.
Our objective is to analyze the potential of these innovative RNA molecules as biomarkers or therapeutic targets and to establish them as appropriate clinical markers or targets.