Here is an overview of the methods we use.
The Clinic-oriented Therapy Assessment Unit tests and develops innovative diagnosis and therapy procedures for ischemic stroke. As the possibility of being able to transfer findings from current laboratory rodent models to human patients is sometimes only very limited, a globally unique large-animal model was established for the translational approach. Using this model means that a therapeutic or diagnostic principle can be tested under conditions which come close to patient treatment in a clinical setting. Both the gyrencephalic brain structure and the size of the brain much more closely resemble the human situation in the sheep model as opposed to in the small animal.
Both active ingredients and cell-therapeutic approaches can be developed and evaluated using this model. Functional characterization occurs through a sensory-motor behaviour test developed especially for this purpose. Imaging in a clinic-oriented environment (CT, MRI, PET in cooperation with the University of Leipzig) permits structural and morphological analyses which can be supplemented by comprehensive histological examinations.
In addition, an MRI-based stereotactic system for intracranial applications is available, which is used for therapeutic purposes (e.g. intracranial stem cell administration) or for inducing pathological conditions (e.g. brain haemorrhage model).