Automated production technologies for mRNA-based drugs

Allogeneic cell therapies are revolutionizing medicine – but until now, their manufacturing has been complex, inflexible, and highly manual. The dynamic expansion system is the next-generation bioprocess module for automated manufacturing of allogeneic NK cell therapies, overcoming these limitations: robust, safe, efficient, and digitally controlled, it enables scalable, standardized production with minimal manual intervention. This ensures not only the highest quality but also significantly reduces costs and accelerates the scale-up of your therapies. Transform your production – where innovation begins – with the dynamic expansion system.

• Reliable cell cultivation – Developed expansion module for maximum process security
• Seamless automation – Cassette-based architecture for automated handling and effortless integration into robotic workflows
• Full transparency – Integrated sensor suite and digital monitoring via digital twins for real-time insights into cultivation
• Maximum safety – Closed, contamination-­free fluidic path
• Intelligent control – Predictive, model-­driven process control for consistent results
• Digitally connected – Pharma 4.0-ready control architecture for seamless integration into digital manufacturing environments

• Flexible cultivation – Supports both sedimentation and suspension states of the cells
• Gentle processes – Enables gentle resuspension and reduces shear stress
• Resource-efficient – Minimizes media consumption while maximizing yield
• Highest quality – Improved homo­geneity and vitality of the culture for better therapeutic outcomes

• Volume adjustment – Automatically adapts internal volume during cultivation based on cell density
• No manual transfers – Eliminates handling steps for increased process safety
• Stable microenvironment – Provides a consistent, scalable environment for cultivating sensitive cell types
• Minimized effort – Reduces operator interventions to a minimum

• Optimized workflow – Streamlines processes in automated bioprocess chains
• Higher process security – Reduces manual handling and increases reproducibility
• Closed system exchange – Enables cassette changes without contamination risk
• Sterile sampling – Allows automated, repeated sampling without compromising sterility

• Monitor pH, dO₂, dCO₂, glucose, and lactate in real time
• Enable digital twin-based monitoring and predictive process adjustments

• Real-time monitoring – Integrated, model-based prediction of cell growth using real-time sensor data for continuous process control
• Automatic optimization – Enables automated media supply based on fore­casted consumption for ongoing improvement of cultivation
• Consistent quality – Ensures uniform product quality across all production batches

• Plug & Produce – Immediate integration into existing production environments without extensive retrofitting
• Full traceability – Comprehensive support for traceability and auditability for regulatory compliance
• Digital documentation – Automated digital batch records for paperless batch reporting