Bite back at periodontitis pathogens

The oral microbiome is home to more than 700 different types of bacteria. A few of these can cause periodontitis, adhering to plaque, especially at the gum line, where they cause inflammation (gingivitis). The resulting chronic periodontitis not only causes the gums to recede and the teeth to become loose. If the bacteria enter the bloodstream, they can also contribute to the development of diabetes, rheumatism, arthritis, cardiovascular disease, chronic inflammatory bowel disease, and even Alzheimer's disease.

Conventional oral care products, such as mouthwashes containing alcohol or the antiseptic chlorhexidine, kill pathogens, but also all other germs. When the oral flora rebuilds itself after treatment, pathogenic germs such as Porphyromonas gingivalis have a head start because they can multiply particularly well on inflamed gums. Healthy germs, on the other hand, grow more slowly, and the oral flora quickly shifts from its natural balance back into dysbiosis – the disease keeps coming back.

Researchers at Fraunhofer IZI have identified a substance that specifically blocks harmful pathogens such as Porphyromonas gingivalis while sparing other germs. The gingivitis pathogens are not killed, but their growth is inhibited. This prevents them from exerting their toxic effect and allows healthy germs to occupy niches that would otherwise be denied to them. In this way, the substance works in harmony with healthy bacteria to gently establish and maintain microbial balance in the mouth.

The market launch took place in mid-2025. The next step is to develop further products to market maturity, including applications in professional dentistry and animal health.